Strategic Approach to Farming Success

This paper is an abstract of a new book for farmers launched on April 8, 2005 (Nell & Napier, 2005). The two authors, Wim Nell of South Africa and Rob Napier of Australia, have respectively 28 and 37 years national and international experience in strategic agricultural management. The book is written for farmers across the world and is dedicated to all farmers. The book takes the reader on a strategic journey to farming success, which consists of 11 stages. At the end of each stage the reader has the opportunity to answer some questions that will guide the process of compiling a strategic plan for a specific farming business. The book opens new horizons for the modern farmer to manage the farming business more successfully.Farming success, strategic approach, strategic farming, scenarios, holistic management., Farm Management,

Accidents on Rural Interstate and Parkway Roads and Their Relation to Pavement Friction

Friction measurements were made with a skid trailer at 70 mph on 820 miles of rural, four-lane, controlled-access routes on the interstate and parkway systems in Kentucky. These facilities were subdivided into test sections and half-mile sites. Accident experience, friction measurements and traffic volumes were obtained for each subdivision. The expression of accident occurrence which correlated best with skid resistance was wet-surface accidents per 100 million vehicle miles. There was a definite trend exhibiting a rapid decrease of accidents with increasing Skid Number (70 mph) to 26 ± 1; thereafter, with increasing Skid Numbers, the rate of decrease was considerably lessened. This trend was developed using test-section data and verified using half-mile sites. Analysis of Peak Slip Numbers and accident occurrences indicated similar trends to those developed with Skid Numbers

SB 206553, a putative 5-HT2C inverse agonist, attenuates methamphetamine-seeking in rats

BACKGROUND: Methamphetamine (meth) dependence presents a substantial socioeconomic burden. Despite the need, there is no FDA-approved pharmacotherapy for psychostimulant dependence. We consider 5-HT(2C) receptors as viable therapeutic targets. We recently revealed that the atypical antidepressant, mirtazapine, attenuates meth-seeking in a rodent model of human substance abuse. Mirtazapine historically has been considered to be an antagonist at 5-HT(2C) receptors, but more recently shown to exhibit inverse agonism at constitutively active 5-HT(2C) receptors. To help distinguish the roles for antagonism vs. inverse agonism, here we explored the ability of a more selective 5-HT(2C) inverse agonist, SB 206553 to attenuate meth-seeking behavior, and compared its effects to those obtained with 5-HT(2C) antagonists, SDZ Ser 082 and SB 242084. To do so, rats were trained to self-administer meth and tested for seeking-like behavior in cue reactivity sessions consisting of contingently presenting meth-associated cues without meth reinforcement. We also explored motor function to determine the influence of SB 206553 and SDZ Ser 082 on motor activity in the presence and absence of meth. RESULTS: Like mirtazapine, pretreatment with SB 206553 (1.0, 5.0, and 10.0 mg/kg), attenuated meth-seeking. In contrast, the antagonists, SDZ Ser 082 (0.1, 0.3, and 1.0 mg/kg) and SB 242084 (3.0 mg/kg) had no effect on cue reactivity (CR). SB 242084 (3.0 mg/kg) failed to attenuate the effects of 5.0 and 10 mg/kg SB 206553 on CR. Motor function was largely unaltered by the 5-HT(2C) ligands; however, SB 206553, at the highest dose tested (10.0 mg/kg), attenuated meth-induced rearing behavior. CONCLUSIONS: The lack of effect by 5-HT(2C) antagonists suggests that meth-seeking and meth-evoked motor activity are independent of endogenous 5-HT acting at 5-HT(2C) receptors. While SB 206553 dramatically impacted meth-evoked behaviors it is unclear whether the observed effects were 5-HT(2C) receptor mediated. Thus, SB 206553 deserves further attention in the study of psychostimulant abuse disorders

Context-Dependent Effects of a Single Administration of Mirtazapine on the Expression of Methamphetamine-Induced Conditioned Place Preference

Re-exposure to cues repeatedly associated with methamphetamine (Meth) can trigger Meth-seeking and relapse in the abstinent abuser. Weakening the conditioned Meth-associated memory during cue re-exposure may provide a means for relapse-reduction pharmacotherapy. Accordingly, we sought to determine if the atypical antidepressant mirtazapine disrupted the persistence of Meth-induced conditioned place preference (CPP) when administered in conjunction with re-exposure to contextual conditioning cues, and if this effect was altered by Meth being present during cue re-exposure. First, we evaluated the effect of mirtazapine on the maintenance of Meth-induced CPP during re-exposure to either the saline- or Meth-paired chamber 12 days after conditioning. Meth-conditioned rats subsequently administered mirtazapine expressed CPP independent of re-exposure to the saline- or Meth-paired chamber; but the magnitude of CPP was significantly less for mirtazapine-treated rats re-exposed to the Meth-paired chamber. Next, we evaluated the effect of mirtazapine on a “reinforced re-exposure” to the Meth-paired context. Administration of mirtazapine vehicle and Meth, prior to re-exposure to the Meth-paired chamber did not disrupt the ability of rats to demonstrate CPP 15 days after conditioning; however, CPP was disrupted when rats were administered mirtazapine and Meth prior to re-exposure to the Meth-paired chamber. These results indicate that the capacity of mirtazapine to diminish Meth-induced CPP is promoted if mirtazapine treatment is coupled with Meth administration in the Meth-associated context and thus appears to be the consequence of disrupting processes necessary to reconsolidate CPP following activation of drug-associated memories

Skid-Test Trailer: Description, Evaluation and Adaptation

A two-wheeled skid-test trailer and towing vehicle were acquired in 1969. The trailer was designed primarily for measurement of steady-state friction at and above normal traffic speeds. Measurement of instantaneous wheel loads also permitted determination of peak or incipient friction. Factors and variables associated with the testing device and calibration and test procedures were investigated and standardized, and the trailer was adopted for routine testing. Comparative tests with the trailers of General Motors, Ohio, and West Virginia were conducted, and the data were correlated. The interim standard method of test using an automobile was correlated with the trailer to permit conversion of data accumulated in preceding years

Skid Resistance of Pavements [Sept. 1972]

Standard pavement types and experimental surfaces on roads throughout Kentucky were evaluated in terms of skid resistance and effects of traffic, wear, and polishing. Friction-vs-speed gradients and the relationships between locked-wheel and incipient friction were determined. Asphaltic concrete pavements on high-speed, four-lane roads were found to be significantly more skid resistant than on two-lane highways and somewhat more skid resistant than concrete surfaces (especially those containing calcareous gravel aggregates). Sand-asphalt surfaces containing significant proportions of limestone sands showed inadequate level of friction for the traffic sustained. Several experimental sand asphalts without limestone sands exhibited greater skid resistance; Kentucky rock asphalt surfaces remain the most skid resistant of all surfaces investigated

Accidents on Rural Interstate and Parkway Roads and Their Relation to Pavement Friction

Friction measurements were made with a skid trailer at 70 mph (31 m/s) on 770 miles (1240 km) of rural, four-lane, controlled-access routes on the interstate and parkway systems in Kentucky. Each construction project was treated as a test section. Accident experience, friction measurements, and traffic volumes were obtained for each. Various relationships between wet-weather accidents and skid resistance were analyzed. The expression of accident occurrence which correlated best with skid and slip resistance was wet-weather accidents per 100 million vehicle miles. Accidents increased greatly as Skid Numbers (70 mph or 31 m/s) decreased from 27 ± 1. Analysis of Peak Slip Numbers and accident occurrences indicated similar trends

Skid Resistance of Pavements [July 1972]

Standard pavement types and experimental surfaces on roads throughout Kentucky were evaluated in terms of skid resistance and effects of traffic, wear, and polishing. Friction-vs-speed gradients and the relationships between locked-wheel and incipient friction were determined. Class I bituminous pavements on high-speed, four-lane roads were found to be significantly more skid resistant than on two-lane highways and somewhat more skid resistant than concrete surfaces (especially those containing calcareous gravel aggregates). Sand-asphalt surfaces containing significant proportions of limestone sands showed inadequate level of friction for the traffic sustained. Several experimental sand asphalts without limestone sands exhibited greater skid resistance; Kentucky rock asphalt surfaces remain the most skid resistant of all surfaces investigated

36 year old man presenting with pancreatitis and a history of recent commencement of orlistat case report

BACKGROUND: Orlistat is an anti-obesity drug licensed in the United Kingdom for 7 years. We present a case of a patient who developed pancreatitis four days after commencing orlistat. CASE PRESENTATION: A 36 year old man presented to hospital with acute severe pancreatitis four days after starting a course of Orlistat, a lipase inhibitor used in the treatment of obesity. A diagnosis of drug related pancreatitis was made by exclusion of other causes of pancreatitis; he was a teetotaller, had a normal serum calcium, had no family history of pancreatitis or hyperlipidaemia, no history of trauma and had no evidence of gallstones on Computerised Tomography scan (CT). CONCLUSION: Orlistat was the only drug that had been started recently and has been associated with pancreatitis previously. We found no case reports of similar cases, however 99 cases of orlistat related pancreatitis have been reported to the Food and Drug Administration (FDA), but no causative link has been found in clinical trials by the drug company. It is therefore not on the list of possible complications or side effects of the drug