258 research outputs found
Quantum Phase transition under pressure in a heavily hydrogen-doped iron-based superconductor LaFeAsO
Hydrogen (H)-doped LaFeAsO is a prototypical iron-based superconductor.
However, its phase diagram extends beyond the standard framework, where a
superconducting (SC) phase follows an antiferromagnetic (AF) phase upon carrier
doping; instead, the SC phase is sandwiched between two AF phases appearing in
lightly and heavily H-doped regimes. We performed nuclear magnetic resonance
(NMR) measurements under pressure, focusing on the second AF phase in the
heavily H-doped regime. The second AF phase is strongly suppressed when a
pressure of 3.0 GPa is applied, and apparently shifts to a highly H-doped
regime, thereby a "bare" quantum critical point (QCP) emerges. A quantum
critical regime emerges in a paramagnetic state near the QCP, however, the
influence of the AF critical fluctuations to the SC phase is limited in the
narrow doping regime near the QCP. The optimal SC condition ( 48 K)
is unaffected by AF fluctuations
肝細胞癌患者において、骨格筋量、腹部脂肪量、内臓肥満が予後に与える影響についての検討-BMIパラドックスの探求-
学位の種別: 課程博士審査委員会委員 : (主査)東京大学特任教授 植木 浩二郎, 東京大学教授 國土 典宏, 東京大学准教授 窪田 直人, 東京大学医科学研究所准教授 桐生 茂, 東京大学特任准教授 脇 裕典University of Tokyo(東京大学
New species of bone-eating worm Osedax from the abyssal South Atlantic Ocean (Annelida, Siboglinidae)
A new species of bone-eating annelid, Osedax braziliensis sp. n., found in a sunken whale carcass at a depth of 4,204 m at the base of the São Paulo Ridge in the South Atlantic Ocean off the Brazilian coast is described. The organism was retrieved using the human-occupied vehicle Shinkai 6500 during the QUELLE 2013 expedition. This is the 26th species of the genus and the first discovery from the South Atlantic Ocean, representing the deepest record of Osedax worldwide to date. This species morphologically resembles Osedax frankpressi but is distinguished by the presence of a yellow bump or patch behind the prostomium and its trunk length. Molecular phylogenetic analysis using three genetic markers (COI, 16S, and 18S) showed that O. braziliensis sp. n. is distinct from all other Osedax worms reported and is a sister species of O. frankpressi
p53-armed oncolytic adenovirus induces autophagy and apoptosis in KRAS and BRAF-mutant colorectal cancer cells
Colorectal cancer (CRC) cells harboring KRAS or BRAF mutations show a more-malignant phenotype than cells with wild-type KRAS and BRAF. KRAS/BRAF-wild-type CRCs are sensitive to epidermal growth factor receptor (EGFR)-targeting agents, whereas KRAS/BRAF-mutant CRCs are resistant due to constitutive activation of the EGFR-downstream KRAS/BRAF signaling pathway. Novel therapeutic strategies to treat KRAS/BRAF mutant CRC cells are thus needed. We recently demonstrated that the telomerase-specific replication-competent oncolytic adenoviruses OBP-301 and p53-armed OBP-702 exhibit therapeutic potential against KRAS-mutant human pancreatic cancer cells. In this study, we evaluated the therapeutic potential of OBP-301 and OBP-702 against human CRC cells with differing KRAS/BRAF status. Human CRC cells with wild-type KRAS/BRAF (SW48, Colo320DM, CACO-2), mutant KRAS (DLD-1, SW620, HCT116), and mutant BRAF (RKO, HT29, COLO205) were used in this study. The antitumor effect of OBP-301 and OBP-702 against CRC cells was analyzed using the XTT assay. Virus-mediated modulation of apoptosis, autophagy, and the EGFR-MEK-ERK and AKT-mTOR signaling pathways was analyzed by Western blotting. Wild-type and KRAS-mutant CRC cells were sensitive to OBP-301 and OBP-702, whereas BRAF-mutant CRC cells were sensitive to OBP-702 but resistant to OBP-301. Western blot analysis demonstrated that OBP-301 induced autophagy and that OBP-702 induced autophagy and apoptosis in human CRC cells. In BRAF-mutant CRC cells, OBP-301 and OBP-702 suppressed the expression of EGFR, MEK, ERK, and AKT proteins, whereas mTOR expression was suppressed only by OBP-702. Our results suggest that p53-armed oncolytic virotherapy is a viable therapeutic option for treating KRAS/BRAF-mutant CRC cells via induction of autophagy and apoptosis
On the distribution of 1550-nm photon pairs efficiently generated using a periodically poled lithium niobate waveguide
We report on the generation of photon pairs in the 1550-nm band suitable for
long-distance fiber-optic quantum key distribution. The photon pairs were
generated in a periodically poled lithium niobate waveguide with a high
conversion-efficiency. Using a pulsed semiconductor laser with a pulse rate of
800 kHz and a maximum average pump power of 50 muW, we obtained a coincidence
rate of 600 s^-1. Our measurements are in agreement with a Poissonian
photon-pair distribution, as is expected from a comparison of the coherence
time of the pump and of the detected photons. An average of 0.9 photon pairs
per pulse was obtained.Comment: 12 pages, 3 figure
Thrombocytosis is associated with worse survival in patients with hepatocellular carcinoma
Background & AimsThrombocytosis is associated with more aggressive tumour biology in many malignancies. There are limited data in patients with hepatocellular carcinoma (HCC), which often occurs in patients with cirrhosis and portal hypertension. We aimed to explore the prognostic value of thrombocytosis in two cohorts of patients with HCC.MethodsWe included 3561 patients from Taiwan and 1145 patients from the USA. Thrombocytopenia was defined as platelet count < 150à 109/L and thrombocytosis as - ¥Â 300 à  109/L at HCC diagnosis. We used multivariable Cox proportional hazard models to identify independent predictors of survival.ResultsThrombocytosis was present in 9.0% and 6.9% of Taiwan and USA patients respectively. Compared to patients with normal platelet counts and those with thrombocytopenia, patients with thrombocytosis had larger tumours, increased vascular invasion and a higher proportion had extrahepatic metastases in both cohorts. In multivariable analysis, thrombocytosis (aHR 1.40, 95% CI 1.23- 1.60) and thrombocytopenia (aHR 1.13, 95% CI 1.04- 1.23) were both associated with worse survival after adjusting for age, gender, liver disease aetiology, Child- Pugh score, maximal tumour size, tumour nodularity, vascular invasion, lymph node or distant metastasis, performance status and alpha- fetoprotein level. Patients with thrombocytosis had a median survival of 6 and 4 months in the Taiwan and USA cohorts, compared to 32 and 14 months for those with normal platelet counts and 38 and 16 months for thrombocytopenic patients.ConclusionThrombocytosis is independently associated with increased tumour burden and worse overall survival among HCC patients.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/162769/2/liv14560.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/162769/1/liv14560_am.pd
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