Microwave Effect for Glycosylation Promoted by Solid Super Acid in Supercritical Carbon Dioxide

The effects of microwave irradiation (2.45 GHz, 200 W) on glycosylation promoted by a solid super acid in supercritical carbon dioxide was investigated with particular attention paid to the structure of the acceptor substrate. Because of the symmetrical structure and high diffusive property of supercritical carbon dioxide, microwave irradiation did not alter the temperature of the reaction solution, but enhanced reaction yield when aliphatic acceptors are employed. Interestingly, the use of a phenolic acceptor under the same reaction conditions did not show these promoting effects due to microwave irradiation. In the case of aliphatic diol acceptors, the yield seemed to be dependent on the symmetrical properties of the acceptors. The results suggest that microwave irradiation do not affect the reactivity of the donor nor promoter independently. We conclude that the effect of acceptor structure on glycosylation yield is due to electric delocalization of hydroxyl group and dielectrically symmetric structure of whole molecule

Primary small-cell neuroendocrine carcinoma of the duodenum – a case report and review of literature

BACKGROUND: Small-cell neuroendocrine carcinoma in the duodenum is an extremely rare neoplasm with poor prognosis. CASE PRESENTATION: A 57-year-old man presented with sudden onset gastrointestinal bleeding and fainting attacks. Duodenoscopy and hypotonic duodenography revealed a 3 × 3 cm protruding tumor with ulcerations situated opposite the ampulla of Vater in the second part of the duodenum. Local excision of the tumor was performed, followed by adjuvant chemotherapy with 5-fluoro uracil and leucovorin. Examination of the tumor by immunohistochemistry and electron microscopy indicated it to be neuroendocrine in nature, expressing synaptophysin and AE1/AE3, and containing dense core granules. The patient showed no sign of recurrence and has been disease-free for more than 48 months after surgery. CONCLUSIONS: Most cases of small-cell neuroendocrine carcinoma in the duodenum show rapid progression of the disease, and even radical surgery with or without chemotherapy do not prevent death. We report a rare subtype of small-cell neuroendocrine carcinoma. This subtype appears to have a much better prognosis, and may be amenable to local excision, if the lesion is away from the ampulla of Vater

General tendencies of stable isotopes and major chemical constituents of the Dome Fuji deep ice core (scientific paper)

Stable isotope compositions of water and major chemical constituents of the Dome Fuji ice core are analyzed and the data sets over the entire depth of the 2503-m core are presented in appropriate time resolution as consecutive series of average value in definite terms. These results based on the first stage analyses allow a temporal climatic dividing of the three glacial-interglacial cycles present in the records. A Comparison of the climatic and environmental characteristics of these climate stages is presented

Prehospital predicting factors using a decision tree model for patients with witnessed out-of-hospital cardiac arrest and an initial shockable rhythm

The effect of prehospital factors on favorable neurological outcomes remains unclear in patients with witnessed out-of-hospital cardiac arrest (OHCA) and a shockable rhythm. We developed a decision tree model for these patients by using prehospital factors. Using a nationwide OHCA registry database between 2005 and 2020, we retrospectively analyzed a cohort of 1,930,273 patients, of whom 86,495 with witnessed OHCA and an initial shockable rhythm were included. The primary endpoint was defined as favorable neurological survival (cerebral performance category score of 1 or 2 at 1 month). A decision tree model was developed from randomly selected 77,845 patients (development cohort) and validated in 8650 patients (validation cohort). In the development cohort, the presence of prehospital return of spontaneous circulation was the best predictor of favorable neurological survival, followed by the absence of adrenaline administration and age. The patients were categorized into 9 groups with probabilities of favorable neurological survival ranging from 5.7 to 70.8% (areas under the receiver operating characteristic curve of 0.851 and 0.844 in the development and validation cohorts, respectively). Our model is potentially helpful in stratifying the probability of favorable neurological survival in patients with witnessed OHCA and an initial shockable rhythm.Tateishi K., Saito Y., Yasufuku Y., et al. Prehospital predicting factors using a decision tree model for patients with witnessed out-of-hospital cardiac arrest and an initial shockable rhythm. Scientific Reports 13, 16180 (2023); https://doi.org/10.1038/s41598-023-43106-w

松本歯科大学病院における小児全身麻酔下集中歯科治療の検討 : 過去11年間の環境要因の変遷について

We investigated the actual child-rearing environment, considering factors such as hygiene training, among 177 children (102 boys, 75 girls) ranging from 1 year and 9 months to 7 years and 2 months in age who underwent intensive dental treatment under general anesthesia in the Department of Pediatric Dentistry, Matsumoto Dental University Hospital between January 1990 and December 2000. The following results were obtained. 1) The annual number of patients slightly increased between 1992 and 1994. Thereafter, the annual number of patients decreased slightly each year. 2) The mean age attreatmentwas 3 years and 7 months (44.5±12.9 months). 3) Concerning the regional distribution, more than 50% of the children came from Nagano Prefecture areas other than Shiojiri City, where our university is located. 4) With respect to feeding methods during infancy, most children were breast fed or mixed breast and bottle fed. Furthermore, any feeding irregularity was noted. 5) The mean interval from birth until the start of weaning was 7.5±4.1 months. The mean interval until completion of weaning was 16.0±6.3 months. 6) 95.5% of the children habitually brushed their teeth. The frequency of tooth brushing was "once a day" or "sometimes" in 69.5% of the children. 7) Overall, 46.9% of the children had received fluoride application

Patched1 Haploinsufficiency Increases Adult Bone Mass and Modulates Gli3 Repressor Activity

SummaryHedgehog (Hh)-Patched1 (Ptch1) signaling plays essential roles in various developmental processes, but little is known about its role in postnatal homeostasis. Here, we demonstrate regulation of postnatal bone homeostasis by Hh-Ptch1 signaling. Ptch1-deficient (Ptch1+/−) mice and patients with nevoid basal cell carcinoma syndrome showed high bone mass in adults. In culture, Ptch1+/− cells showed accelerated osteoblast differentiation, enhanced responsiveness to the runt-related transcription factor 2 (Runx2), and reduced generation of the repressor form of Gli3 (Gli3rep). Gli3rep inhibited DNA binding by Runx2 in vitro, suggesting a mechanism that could contribute to the bone phenotypes seen in the Ptch1 heterozygotes. Moreover, systemic administration of the Hh signaling inhibitor cyclopamine decreased bone mass in adult mice. These data provide evidence that Hh-Ptch1 signaling plays a crucial role in postnatal bone homeostasis and point to Hh-Ptch1 signaling as a potential molecular target for the treatment of osteoporosis

中国上海市小児における乳歯列形態の検討 : 正常咬合児72例の模型から

To obtain the dimensional data of the dental casts of growing and developing Chinese children, and to compare the data to the Japanese, we have performed dental examinations on children in the kindergarten attached to Shanghai Teachers\u27 University in Shanghai since 1996. As study materials, dental casts obtained between 1996 and 1999 from 72 Chinese children aged 3 to 6 years with normal primary occlusion were used to evaluate the mesio-distal crown diameters of the primary teeth, the sizes of the primary dental arch, and the standard values and frequency distributions of primary occlusion. 1. Males showed higher values in mesio-distal crown diameters in deciduous teeth, and the size of dental arch than females. 2. In regard to the interdental spaces both in the maxilla and mandible, primate and developmental spaces together were most frequently observed. 3. In regard to the occlusal relationship, the incidence of terminal planes was higher in the order of Vertical type > Mesial step type > Distal step type, and the incidence of primary canine occlusal relationship was higher in the order of type I>type III>type II. 4. The items that were thought to be characteristic of Chinese children were the frequency of only primate spaces, and the incidence of the Mesial step type of terminal plane and type III primary canine occlusal relationship

Multicolor and multi-spot observations of Starlink's Visorsat

This study provides the results of simultaneous multicolor observations for the first Visorsat (STARLINK-1436) and the ordinary Starlink satellite, STARLINK-1113 in the $U$, $B$, $V$, $g'$, $r$, $i$, $R_{\rm C}$, $I_{\rm C}$, $z$, $J$, $H$, and $K_s$ bands to quantitatively investigate the extent to which Visorsat reduces its reflected light. Our results are as follows: (1) in most cases, Virorsat is fainter than STARLINK-1113, and the sunshade on Visorsat, therefore, contributes to the reduction of the reflected sunlight; (2) the magnitude at 550 km altitude (normalized magnitude) of both satellites often reaches the naked-eye limiting magnitude ($<$ 6.0); (3) from a blackbody radiation model of the reflected flux, the peak of the reflected components of both satellites is around the $z$ band; and (4) the albedo of the near infrared range is larger than that of the optical range. Under the assumption that Visorsat and STARLINK-1113 have the same reflectivity, we estimate the covering factor, $C_{\rm f}$, of the sunshade on Visorsat, using the blackbody radiation model: the covering factor ranges from $0.18 \leq C_{\rm f} \leq 0.92$. From the multivariable analysis of the solar phase angle (Sun-target-observer), the normalized magnitude, and the covering factor, the phase angle versus covering factor distribution presents a moderate anti-correlation between them, suggesting that the magnitudes of Visorsat depend not only on the phase angle but also on the orientation of the sunshade along our line of sight. However, the impact on astronomical observations from Visorsat-designed satellites remains serious. Thus, new countermeasures are necessary for the Starlink satellites to further reduce reflected sunlight.Comment: 31 pages, 9 figures, published in PAS