Changes in 12-Year First-Line Eradication Rate of Helicobacter pylori Based on Triple Therapy with Proton Pump Inhibitor, Amoxicillin and Clarithromycin

A triple therapy based on a proton pump inhibitor (PPI), amoxicillin (AMPC), and clarithromycin (CAM) is recommended as a first-line therapy for Helicobacter pylori (H. pylori) eradication and is widely used in Japan. However, a decline in eradication rate associated with an increase in prevalence of CAM resistance is viewed as a problem. We investigated CAM resistance and eradication rates over time retrospectively in 750 patients who had undergone the triple therapy as first-line eradication therapy at Nagoya City University Hospital from 1995 to 2008, divided into four terms (Term 1: 1997–2000, Term 2: 2001–2003, Term 3: 2004–2006, Term 4: 2007–2008). Primary resistance to CAM rose significantly over time from 8.7% to 23.5%, 26.7% and 34.5% while the eradication rate decreased significantly from 90.6% to 80.2%, 76.0% and 74.8%. Based on the PPI type, significant declines in eradication rates were observed with omeprazole or lansoprazole, but not with rabeprazole. A decrease in the H. pylori eradication rate after triple therapy using a PPI + AMPC + CAM has been acknowledged, and an increase in CAM resistance is considered to be a factor. From now on, a first-line eradication regimen that results in a higher eradication rate ought to be investigated

Fixed point observation for daily snow surface monitoring along a latitudinal transect from the coast to the inland of Antarctica using camera images

The Tenth Symposium on Polar Science/Ordinary sessions: [OM] Polar Meteorology and Glaciology, Wed. 4 Dec. / Entrance Hall (1st floor) , National Institute of Polar Researc

A finite element analysis of the effects of archwire size on orthodontic tooth movement in extraction space closure with miniscrew sliding mechanics

Abstract Background Sliding mechanics with miniscrews is recently used for extraction space closure. The purpose of this study was to elucidate how and why the archwire size affects long-term tooth movement in miniscrew sliding mechanics. Methods Long-term orthodontic tooth movements were simulated based on a remodeling law of the alveolar bone by using a finite element method, in which the bracket rotated freely within a clearance gap (a play) of the archwire-bracket slot. The archwire size was changed to 0.021, 0.018, and 0.016 in. for the 0.022-in. bracket. Result Lingual crown tipping and extrusion of the incisors increased with decreasing the archwire size. Movements of the posterior teeth were approximately the same irrespective of archwire size. Conclusions When decreasing the archwire size, a play of the archwire-bracket slot, as well as the elastic deformation of the archwire, resulted in lingual tipping of the incisors. This tipping led to extrusion of the incisors

A review of cuttlefish basket trap fishery

Abstract While cuttlefish basket trap fishery is a traditional fishing activity with a long history, there has never been an article which comprehensively assesses this type of fishery. The present review compiles existing knowledge on cuttlefish trap fishery and the findings of interviews conducted with fishermen by the authors. It mainly covers such issues as the history of cuttlefish trap fishery, relationship between traps and the catch, structure of traps, characteristics of fishing grounds and trap operating methods. In addition, the spawning habits of cuttlefish, which are closely related to trap fishery, are briefly described and the credibility of various theories on the catching process especially the motivation of cuttlefish to enter a trap is examined. The review concludes that because of the virtual absence of research on cuttlefish trap fishery, behavioral research is extremely necessary to establish fishery oriented resource management

Tooth Movement Efficacy of Retraction Spring Made of a New Low Elastic Modulus Material, Gum Metal, Evaluated by the Finite Element Method

The aim of this study was to evaluate the tooth movement efficacy of retraction springs made of a new β-titanium alloy, “gum metal”, which has a low Young’s modulus and nonlinear super elasticity. Using double loop springs incorporated into an archwire made of gum metal (GUM) and titanium molybdenum alloy (TMA), the maxillary anterior teeth were moved distally to close an extraction space. The long-term movements were simulated by the finite element method. Its procedure was constructed of two steps, with the first step being the calculation of the initial tooth movement produced by elastic deformation of the periodontal ligament, and in the second step, the alveolar socket was moved by the initial tooth movement. By repeating these steps, the tooth moved by accumulating the initial tooth movement. The number of repeating calculations was equivalent to an elapsed time. In the GUM and TMA springs, the anterior teeth firstly tipped lingually, and then became upright. As a result of these movements, the canine could move bodily. The amount of space closure in GUM spring was 1.5 times that in TMA spring. The initial tipping angle of the canine in the GUM spring was larger than that in the TMA spring. The number of repeating calculations required for the bodily movement in the GUM spring was about two times that in the TMA spring. It was predicted that the speed of space closure in the GUM spring was smaller than that in the TMA spring

(Table 1) Age determination of sediment core KH92-15cBX

A sediment core collected from Caroline Basin, western tropical Pacific was analyzed for lipid class compounds (aliphatic hydrocarbons, long-chain alkenones, fatty alcohols, sterols, and fatty acids) to reconstruct changes in paleoenvironments during the last 23.3 kyr. Around the boundary between the glacial and deglacial periods (19 ka), mass accumulation rates of terrestrial biomarkers, C25-C35 n-alkanes, C24-C28 fatty alcohols, and C23-C34 fatty acids, were found to decrease significantly and stayed in low levels during the deglaciation, suggesting a reduction of atmospheric transport of continental materials during that time. In the same period, mass accumulation rates of C17-C20 n-alkanes, pristane, cholesterol, and dinosterol which are thought to be mainly derived from marine organisms also decreased, suggesting a significant drop of marine biological productivity. The decreased biological productivity in the western tropical Pacific may be caused by a reduced supply of nutrients from upwelling which is associated with decreased wind velocity and/or caused by a shift of upwelling zone