A motion rule for human-friendly robots basedinvestigations and its application to mobile robot on electrodermal activity

This paper investigates impressions on the robot motion based on EDA experiments, deduces a motion rule for human-friendly robots from the investigations, and applies it to a mobile robot experimental apparatus. In our previous work, it was suggested that actuation noise come from the robots tended to raise the sympathetic nerve system (SNS) response of the heart rate variability. In another experiment it is observed that blocking out either the sound or the sight attenuated the electrodermal activity (EDA), which reflects the SNS, to the robot motion. In the present work, the experiment was designed not so as to avoid the influence of the habituation differently from the previous experiments, which was the significant factor contributing to reducing the EDA responses. As a result of statistical analysis, it was concluded that the present work supported the result of the previous work. Based on these investigations, we deduced the motion rule for human-friendly robots from this investigation, that robots must reduce their motion speed in the immediate vicinity of humans. We constructed the experimental setup that a mobile robot approached human with its speed decreased in conformity with the rule. To estimate the distance from the human, the skin color detection and depth-from-focus techniques were applied to a monocular color video camera system with pan/tilt/zoom operation. The experimental result showed that a proper choice of commands could perform the robot motion to reduce its speed in the immediate vicinity of the human

Anomalous negative excursion of carbon isotope in organic carbon after the last Paleoproterozoic glaciation in North America

Early Paleoproterozoic time (2.5–2.0 Ga) spanned a critical phase in Earth's history, characterized by repeated glaciations and an increase in atmospheric oxygen (the Great Oxidation Event (GOE)). Following the last and most intense glaciation of this period, marine carbonates record a large positive excursion of δ^(13)C value (termed the “Lomagundi event”) between about 2.2 and 2.1 Ga coinciding with the global appearances of red beds and sulfates, which suggest an accumulation of high levels of atmospheric oxygen. Here we report the discovery of large negative excursions of δ^(13)C in organic matter (down to −55‰) from quartzose sandstones (of the Marquette Range and the Huronian Supergroups, North America) intermediate in age between the last Paleoproterozoic glaciation and the possible onset of the Lomagundi event. The negative excursion is concomitant with the appearance of intensely weathered quartzose sandstones, which may represent hot and humid conditions. There are some interpretations that potentially explain the negative excursions: (1) redeposition of older ^(13)C-depleted kerogen, (2) later post-depositional infiltration of oil, (3) active methane productions by methanogens in shallow-marine environments, or (4) dissociation of methane hydrate. If the latter two were the case, they would provide clues for understanding the environmental change connecting the intense glaciation and an increase in oxygen

Prophylactic clip closure for mucosal defects is associated with reduced adverse events after colorectal endoscopic submucosal dissection: a propensity-score matching analysis

博士（医学）乙日本医科大学202

Characteristics of RF Resonant Field - Electric Field in Plasma -

書誌情報のみBibliographic data Onl

Molecular Pathogenesis of Colorectal Cancer: Impact of Oncogenic Targets Regulated by Tumor Suppressive miR-139-3p

We recently determined the RNA sequencing-based microRNA (miRNA) expression signature of colorectal cancer (CRC). Analysis of the signature showed that the expression of both strands of pre-miR-139 (miR-139-5p, the guide strand, and miR-139-3p, the passenger strand) was significantly reduced in CRC tissues. Transient transfection assays revealed that expression of miR-139-3p blocked cancer cell malignant transformation (e.g., cell proliferation, migration, and invasion). Notably, expression of miR-139-3p markedly blocked RAC-alpha serine/threonine-protein kinase (AKT) phosphorylation in CRC cells. A combination of in silico database and gene expression analyses of miR-139-3p-transfected cells revealed 29 putative targets regulated by miR-139-3p in CRC cells. RNA immunoprecipitation analysis using an Argonaute2 (AGO2) antibody revealed that KRT80 was efficiently incorporated into the RNA-induced silencing complex. Aberrant expression of Keratin 80 (KRT80) was detected in CRC clinical specimens by immunostaining. A knockdown assay using small interfering RNA (siRNA) targeting KRT80 showed that reducing KRT80 expression suppressed the malignant transformation (cancer cell migration and invasion) of CRC cells. Importantly, inhibiting KRT80 expression reduced AKT phosphorylation in CRC cells. Moreover, hexokinase-2 (HK2) expression was reduced in cells transfected with the KRT80 siRNAs or miR-139-3p. The involvement of miRNA passenger strands (e.g., miR-139-3p) in CRC cells is a new concept in miRNA studies. Our tumor-suppressive miRNA-based approach helps elucidate the molecular pathogenesis of CRC