Ethyl 1-(2-bromo­propano­yl)-4-hydr­oxy-2,6-diphenyl-1,2,5,6-tetra­hydro­pyridine-3-carboxylate

The title compound, C23H24BrNO4, crystallizes with two independent mol­ecules per asymmetric unit. The methyl group of the ethoxy­carbonyl unit is disordered over two positions, with occupancies of 0.715 (12) and 0.285 (12) in one of the independent mol­ecules, and 0.529 (11) and 0.471 (11) in the other mol­ecule. In one of the independent mol­ecules, the tetra­hydro­pyridine ring adopts a half-chair conformation, while in the other it is in a distorted envelope conformation. In each independent mol­ecule, an intra­molecular O—H⋯O hydrogen bond generates an S(6) ring motif. The two independent mol­ecules are linked via C—H⋯O hydrogen bonds, forming a chain along the c axis

Bis(2,6-diamino­pyridinium) bis­(hydrogen oxalate) monohydrate

The asymmetric unit of the title compound, 2C5H8N3 +·2C2HO4 −·H2O, contains two crystallographically independent 2,6-diamino­pyridinium cations, a pair of hydrogen oxalate anions and a water mol­ecule. Both 2,6-diamino­pyridinium cations are planar, with maximum deviations of 0.011 (2) and 0.015 (1) Å, and are protonated at the pyridine N atoms. The hydrogen oxalate anions adopt twisted conformations and the dihedral angles between the planes of their carboxyl groups are 31.01 (11) and 63.48 (11)°. In the crystal, the cations, anions and water mol­ecules are linked via O—H⋯O and N—H⋯O hydrogen bonds, forming a three-dimensional network

Plant derived exosome- like Nanovesicles: an updated overview

abstract: Exosomes are nanovesicles in the size range of 30–150 nm, produced by mammalian and plant cells. They have the lipid bilayer enclosing a unique mix of biologically active components including proteins, nucleic acids, metabolites and lipids, that depend on their source of origin. The plant derived nanovesicles are gaining considerable research attention due to their ability to be absorbed from the dietary sources. Their bioactive components impart many therapeutic properties to them such as anti-tumorigenic, anti-oxidative, anti-inflammatory, hepatoprotective effects and tissue regeneration. The possibilities of using plant derived exosomes for drug delivery is also promising. This review focusses on the biogenesis and biological nature of exosomes derived from plants and describes their various inherent therapeutic properties. It sheds light on the recently developed methods to study them. The existing challenges in the exosomal research as well as the future prospective are highlighted. Overall, it is an update on the advancements on the research in plant exosomes which can provide a replacement for toxic synthetic drugs and possibilities for disease therapy

4,8,9,10-Tetraphenyl-1,3-diazaadamantan-6-one acetone hemisolvate

In the title compound, $C_{32}H_{28}N_{2}O·0.5C_3H_6O$, the two axial and two equatorial phenyl substituents are essentially planar. There are no hydrogen-bonded interactions between the two independent molecules in the asymmetric unit. The crystal packing is characterized by $C-H{...}O$ interactions. The solvent (acetone) molecule in the crystal structure significantly influences the packing, features of which are distinctly different from those of unsolvated 4,8,9,10-tetraphenyl-1,3-diazaadamantan-6-one and its methoxy- and chloro-substituted analogues

4,8,9,10-Tetraphenyl-1,3-diazaadamantan-6-one

In the molecule of the title compound, $C_{32}H_{28}N_{2}O$, two of the four phenyl substituents occupy axial and the other two occupy equatorial positions relative to their respective $C_{5}N$ rings of the adamantane framework. The crystal packing is characterized by weak $C-H{...}O$ interactions. The packing features are distinctly different from those of the crystals of the methoxy- and chloro-substituted analogues