CYP3A induction by liver x receptor ligands in primary cultured rat and mouse hepatocytes is mediated by the pregnane X receptor. Drug Metab. Dispos

This article is available online at http://dmd.aspetjournals.org A common theme in cell physiology is that endogenous metabolites regulate their own levels, through both feed-back and feed-forward mechanisms. Many of these molecules exert their effects by activating transcription factors of the nuclear receptor superfamily. A prominent class of such endogenous metabolites is the "oxysterol