Phytochemical constituents and antioxidant activity of various fractions of Guazuma tomentosa root heartwood

Guazuma tomentosa is an important medicinal plant. The present investigation deals with GC-MS analysis of pet.ether, dichloromethane and ethyl acetate fractions of root heartwood of  G. tomentosa. In antioxidant activity of these fractions by employing DPPH free radical scavenging effect and FRAP total reduction capability method dichloromethane fraction was most effective exhibiting activity nearly equivalent to that of ascorbic acid (standard) at higher concentration, which could be attributed to the phenolic constituents in this fraction. Results indicated that dichloromethane fraction can be a potential source of natural antioxidant agents

Cohomology and deformations of compatible Leibniz algebras

In this paper we study a cohomology theory of compatible Leibniz algebra. We construct a graded Lie algebra whose Maurer-Cartan elements characterize the structure of compatible Leibniz algebras. Using this, we study cohomology, infinitisimal deformations, Nijenhuis operator and their relation for compatible leibniz algebras. Finally using cohomology of compatible Leibniz algebra with coefficients in an arbitrary representation we study the abelian extensions of compatible Leibniz algebra.Comment: 20 page

Is hysterolaparoscopy a real theranostic approach for anatomical barriers in female fertility? A future argument

Background: Hysterolaparoscopy is a modality that provides the real time abdomino-pelvic view during diagnosis in infertile female patients and any pathology is noticed can be tackled at the same time. So we investigate the theranostic application of hysterolaparoscopy in structural causes of female infertility in present study.Methods: Authors prospectively evaluate 157 female patients (mean age 27.7 years) diagnosed as infertile, underwent hysterolaparoscopy during diagnostic work-up.  All the enlisted patients fulfilled the criteria of infertility. The noticed anatomical abnormalities in the hysterolaparoscopy were tackled at the same time if possible.Results: Of the 157 infertile female patients, 93 (~59.2%) were of primary infertility and remaining 64 (~41.8%) were secondary infertility patients. Hysterolaparoscopy showed abnormalities in 125/157 (~85.0%) patients. The detected hysterolaparoscopic abnormalities were distributed in 77/93 (~82.8%) primary and 48/64 (~75.0%) secondary infertility patients. Of the 125 patients with abnormal hysterolaparoscopic findings, 121 (~96.8%) experienced for active therapeutic interventions. All of the 48 secondary infertility patients with hysterolaparoscopic abnormalities experienced for active hysterolaparoscopic interventions. Of 77 patients with hysterolaparoscopic abnormality in primary infertility group, 73 (~94.8%) experienced active intervention. Only four patients with streak ovaries and hypoplastic uterus, few tiny fibroids and adenomyosis did not undergo for active hysterolaparoscopic intervention.Conclusions: Authors concluded that hysterolaparoscopy has a better theranostic approach for the anatomical barriers of female fertility so it can be performed in the initial phases of the infertility diagnostic work-up

Chocolate cyst became ovarian abscess following IVF: a serious surgical emergency

We are reporting a rare case of ovarian abscess in an endometrioma following ultrasound guided oocyte retrieval during in vitro fertilization technique. Ovarian abscess within an endometrioma is a rare gynaecological problem. We are presenting a case of a giant abscess formation in an endometrioma following in vitro fertilization in a 36-year-old woman in view of secondary infertility. She presented with high grade fever with chills and rigor for more than 2 months associated with pain in abdomen with a progressively increasing lower abdominal mass. Patient was treated at a tertiary care hospital with multidisciplinary approach. Laparotomy was performed, and two litres of the foul-smelling pus was drained, followed by bilateral salpingooophorectomy. Uterus was left in situ to preserve her future fertility potential. Histology of the specimen confirmed endometriotic nature of the cyst. Pus on culture sensitivity was sterile. Patient had an uneventful recovery and was discharged on the 7th post-operative day. In our case endometrioma presented as failure of in vitro fertilization technique followed by a medical illness. This case highlights that endometrioma became not only a cause of failure of in vitro fertilization technique but also presented as a medical illness and should be dealt as one

Appropriateness of perioperative antibiotics in thyroid surgery

Background: Most of the guidelines do not recommend routine antibiotics prophylaxis in clean head and neck surgery like thyroidectomy. In contrary to the recommendation, antibiotics are being routinely prescribed in perioperative period for various duration in many centers of Nepal. This study was aimed to find out the need of postoperative antibiotics in surgeries for thyroid related problems. Methods: Records of all patients who had undergone surgery for thyroid related problems from Jan, 2019 to Sept, 2022 were retrospectively reviewed for patterns of antibiotic use, apart from preincision antibiotic, in postoperative period which was classified as group A – no antibiotics, group B – shorter course of antibiotics (≤3 days) and group C – longer course of antibiotics (>3 days). The occurrence of surgical site infection (SSI) was recorded. Results: During the study period, 77 patients underwent surgery for thyroid related problems, out of which five were excluded (records not found in four cases and one patient was ASA III). Two out of 72 (2.77 %) patients developed superficial incisional SSI which was managed conservatively. One patient in each group A (50) and group B (8) developed SSI. Conclusion: Postoperative antibiotics can be avoided safely even in our setup in clean head and neck surgeries like thyroidectomy without increase in the risk of SSI thus reducing the cost to the patients. &nbsp

Unusual metastatic sex cord stromal tumor - staging and response assessment

Metastatic sex cord stromal tumor (SCST) is rare and contributing <1% of ovarian tumors. A 42-year-old female presented with lower abdominal pain for 2 months. Ultrasonography revealed masses in the abdominal and pelvic. USG guided biopsy from the pelvic mass revealed SCST. For staging, whole body F-18 fluorodeoxyglucose positron emission tomography-computed tomography was performed and revealed heterogenous mildly FDG avid retroperitoneal and bilateral pelvic masses with lung nodules. To confirm the nature of the lung nodule; PET-CT guided biopsy performed and revealed metastatic SCST. After three cycle of chemotherapy, clinical, biochemical and imaging show partial response to treatment

Recent advances in heavy metal/metalloid ion treatment from wastewater using nanocomposites and bionanocomposites

Wastewater remediation is of paramount importance for the water-stressed modern civilization from the perspective of sustainable development and the management of limited freshwater resources. Contaminants such as heavy metal and metalloid ions, toxic dyes, and pathogenic microbes present in the aquatic ecosystem have adverse effects not only on the environment but also on human health. Traditional wastewater remediation processes are costly, energy-consuming, and have less efficiency in removing pollutants from wastewater. Multi-phasic nanomaterials or nanocomposites have enormous potential for removing contaminants from water bodies. These materials have an enormous tunable surface area for interacting with the target toxicants and are extremely stable in the aquatic system, but they readily agglomerate. Many research groups have exploited biosorption, bioleaching, and bioprecipitation capacities of fungal hyphae for wastewater remediation. Recently, researchers have attempted to explore the synergistic effect of the bionanocomposite of fungal hyphae and nanomaterials for removing pollutants from wastewater. This bionanocomposite has already shown promise as a superior material for wastewater treatment and can easily be separated from the polluted water for reuse over several cycles. The bionanocomposite-mediated decontamination of water can lead to a total paradigm shift in wastewater management strategies

Imaging resemblance but diagnostic disparity in cervix cancer: a rare case report

F-18 FDG PET-CT is an establish modality for staging of cervical cancer. The high uptake value in PET with no evidence of necrosis in CECT is generally understood malignant pathology in known cancer patients. A 47 year-old-female with cervix carcinoma underwent staging FDG PET-CT. It showed FDG avid primary lesion in cervix with FDG avid pelvic, retroperitoneal, mediastinal and supraclavicular lymph nodes. USG guided FNA from the supraclavicular lymph node revealed tuberculosis. Now patient scheduled for ATT and chemotherapy