Science Objectives of the Ganymede Laser Altimeter (GALA) for the JUICE Mission

Laser altimetry is a powerful tool for addressing the major objectives of planetary physics and geodesy, and have been applied in planetary explorations of the Moon, Mars, Mercury, and the asteroids Eros, and Itokawa. The JUpiter Icy Moons Explorer (JUICE), led by European Space Agency (ESA), has started development to explore the emergence of habitable worlds around gas giants. The Ganymede Laser Altimeter (GALA) will be the first laser altimeter for icy bodies, and will measure the shape and topography of the large icy moons of Jupiter, (globally for Ganymede, and using flyby ground-tracks for Europa and Callisto). Such information is crucial for understanding the formation of surface features and can tremendously improve our understanding of the icy tectonics. In addition, the GALA will infer the presence or absence of a subsurface ocean by measuring the tidal and rotational responses. Furthermore, it also improves the accuracy of gravity field measurements reflecting the interior structure, collaborating with the radio science experiment. In addition to range measurements, the signal strength and the waveform of the laser pulses reflected from the moon's surface contain information about surface reflectance at the laser wavelength and small scale roughness. Therefore we can infer the degrees of chemical and physical alterations, e.g., erosion, space weathering, compaction and deposition of exogenous materials, through GALA measurements without being affected by illumination conditions. JUICE spacecraft carries ten science payloads including GALA. They work closely together in a synergistic way with GALA being one of the key instruments for understanding the evolution of the icy satellites Ganymede, Europa, and Callisto.Comment: 10 pages, 6 figures, accepted for publication in Trans. JSASS Aerospace Tech. Japa

The Ganymede Laser Altimeter (GALA) for the Jupiter Icy Moons Explorer (JUICE): Mission, science, and instrumentation of its receiver modules

The Jupiter Icy Moons Explorer (JUICE) is a science mission led by the European Space Agency, being developed for launch in 2023. The Ganymede Laser Altimeter (GALA) is an instrument onboard JUICE, whose main scientific goals are to understand ice tectonics based on topographic data, the subsurface structure by measuring tidal response, and small-scale roughness and albedo of the surface. In addition, from the perspective of astrobiology, it is imperative to study the subsurface ocean scientifically. The development of GALA has proceeded through an international collaboration between Germany (the lead), Japan, Switzerland, and Spain. Within this framework, the Japanese team (GALA-J) is responsible for developing three receiver modules: the Backend Optics (BEO), the Focal Plane Assembly (FPA), and the Analog Electronics Module (AEM). Like the German team, GALA-J also developed software to simulate the performance of the entire GALA system (performance model). In July 2020, the Proto-Flight Models of BEO, FPA, and AEM were delivered from Japan to Germany. This paper presents an overview of JUICE/GALA and its scientific objectives and describes the instrumentation, mainly focusing on Japan’s contribution

The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

「コロナ制圧タスクフォース」COVID-19患者由来の血液細胞における遺伝子発現の網羅的解析 --重症度に応じた遺伝子発現の変化には、ヒトゲノム配列の個人差が影響する--. 京都大学プレスリリース. 2022-08-23.Coronavirus disease 2019 (COVID-19) is a recently-emerged infectious disease that has caused millions of deaths, where comprehensive understanding of disease mechanisms is still unestablished. In particular, studies of gene expression dynamics and regulation landscape in COVID-19 infected individuals are limited. Here, we report on a thorough analysis of whole blood RNA-seq data from 465 genotyped samples from the Japan COVID-19 Task Force, including 359 severe and 106 non-severe COVID-19 cases. We discover 1169 putative causal expression quantitative trait loci (eQTLs) including 34 possible colocalizations with biobank fine-mapping results of hematopoietic traits in a Japanese population, 1549 putative causal splice QTLs (sQTLs; e.g. two independent sQTLs at TOR1AIP1), as well as biologically interpretable trans-eQTL examples (e.g., REST and STING1), all fine-mapped at single variant resolution. We perform differential gene expression analysis to elucidate 198 genes with increased expression in severe COVID-19 cases and enriched for innate immune-related functions. Finally, we evaluate the limited but non-zero effect of COVID-19 phenotype on eQTL discovery, and highlight the presence of COVID-19 severity-interaction eQTLs (ieQTLs; e.g., CLEC4C and MYBL2). Our study provides a comprehensive catalog of whole blood regulatory variants in Japanese, as well as a reference for transcriptional landscapes in response to COVID-19 infection

DOCK2 is involved in the host genetics and biology of severe COVID-19

「コロナ制圧タスクフォース」COVID-19疾患感受性遺伝子DOCK2の重症化機序を解明 --アジア最大のバイオレポジトリーでCOVID-19の治療標的を発見--. 京都大学プレスリリース. 2022-08-10.Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge. Here we conducted a genome-wide association study (GWAS) involving 2, 393 cases of COVID-19 in a cohort of Japanese individuals collected during the initial waves of the pandemic, with 3, 289 unaffected controls. We identified a variant on chromosome 5 at 5q35 (rs60200309-A), close to the dedicator of cytokinesis 2 gene (DOCK2), which was associated with severe COVID-19 in patients less than 65 years of age. This risk allele was prevalent in East Asian individuals but rare in Europeans, highlighting the value of genome-wide association studies in non-European populations. RNA-sequencing analysis of 473 bulk peripheral blood samples identified decreased expression of DOCK2 associated with the risk allele in these younger patients. DOCK2 expression was suppressed in patients with severe cases of COVID-19. Single-cell RNA-sequencing analysis (n = 61 individuals) identified cell-type-specific downregulation of DOCK2 and a COVID-19-specific decreasing effect of the risk allele on DOCK2 expression in non-classical monocytes. Immunohistochemistry of lung specimens from patients with severe COVID-19 pneumonia showed suppressed DOCK2 expression. Moreover, inhibition of DOCK2 function with CPYPP increased the severity of pneumonia in a Syrian hamster model of SARS-CoV-2 infection, characterized by weight loss, lung oedema, enhanced viral loads, impaired macrophage recruitment and dysregulated type I interferon responses. We conclude that DOCK2 has an important role in the host immune response to SARS-CoV-2 infection and the development of severe COVID-19, and could be further explored as a potential biomarker and/or therapeutic target

Float zone growth and spectral properties of Cr,Nd:CaYAlO4 single crystals

Cr,Nd:CaYAlO4 single crystals were grown by the floating zone method and their spectroscopic properties were investigated. Many voids were observed in the crystals grown with a stoichiometric feed rod even at a relatively low growth rate of 2.5 mm/h, while a void-free crystal was grown at the same growth rate using a feed rod the composition of which was Y-rich to Ca. These results indicate that voids were attributable to constitutional supercooling due to the segregation of main constituents caused by the difference in congruent and stoichiometric compositions. The as-grown crystals were deep red and showed strong absorption in the wavelength region of 320-600 nm. The absorption cross section for sigma-polarization at 430 nm, where Cr,Nd:YAG has the maximum absorption, is about 1160 x 10(-20) cm(2), which is 165 times as large as that of Cr,Nd:YAG. By pumping at 400 nm, which is a pad of the absorption band of Cr3+ Cr,Nd:CaYAlO4 showed fluorescence bands around 900 am and 1080 nm by Nd3+ indicating energy transfer from Cr3+ to Nd3+ in the crystal. Cr,Nd:CaYAlO4 single crystals are therefore one of the promising gain media for solar-pumped solid state laser systems

Effect of Phase Pattern of Antennas Onboard Flying Spin Satellites on Doppler Measurements

The effect of the phase patterns of antennas onboard flying spin satellites on the Doppler measurements is reported. Phase patterns mean that there are deviations in wave fronts from perfect sphericity, expressed as a function of the angular position around the antenna. We analyzed what effect the phase patterns of dipole and patch antennas onboard two flying spin satellites, Rstar and Vstar, used in the Japanese lunar mission, SELENE (KAGUYA), had on 2-way and 4-way Doppler measurements, and detected higher harmonics in the spin frequency up to an order of 26 in the Doppler frequency. We developed a low-pass filter (LPF) using a Kaiser window, with the optimal parameters empirically determined, to remove the influence of phase patterns and to precisely conserve information on the lunar gravity field. We processed the 2-way and 4-way Doppler data of SELENE by using LPF. After using LPF, a high degree of accuracy of about 0.001 Hz was achieved for the 2-way Doppler measurements, and signals that reflected the gravity field on the far side of the Moon were first detected from the 4-way Doppler data. We also suggested a method for estimating the phase response of satellite antennas using the Doppler frequency variations. In order to estimate the Doppler frequency variation, a filtering technique was adopted to extract the harmonics of interest in the residual signal, from which the antenna phase pattern was derived

Science Objectives of the Ganymede Laser Altimeter (GALA) for the JUICE Mission

Abstract Laser altimetry is a powerful tool for addressing the major objectives of planetary physics and geodesy. Through measurements of distances between a spacecraft and the surface of the planetary bodies, it can be used to determine the global shape and radius: global, regional, and local topography: tidal deformation: and rotational states including physical librations. Laser altimeters have been applied in planetary explorations of the Moon, Mars, Mercury, and the asteroids Eros, and Itokawa. The JUpiter Icy Moons Explorer (JUICE), led by European Space Agency (ESA), has started development to explore the emergence of habitable worlds around gas giants. The Ganymede Laser Altimeter (GALA) will be the first laser altimeter for icy bodies, and will measure the shape and topography of the large icy moons of Jupiter, (globally for Ganymede, and using flyby ground-tracks for Europa and Callisto). Such information is crucial for understanding the formation of surface features and can tremendously improve our understanding of the icy tectonics. In addition, the GALA will infer the presence or absence of a subsurface ocean by measuring the tidal and rotational responses. Furthermore, it also improves the accuracy of gravity field measurements reflecting the interior structure, collaborating with the radio science experiment. In addition to range measurements, the signal strength and the waveform of the laser pulses reflected from the moon's surface contain information about surface reflectance at the laser wavelength and small scale roughness. Therefore we can infer the degrees of chemical and physical alterations, e.g., erosion, space weathering, compaction and deposition of exogenous materials, through GALA measurements without being affected by illumination conditions. JUICE spacecraft carries ten science payloads including GALA. They work closely together in a synergistic way with GALA being one of the key instruments for understanding the evolution of the icy satellites Ganymede, Europa, and Callisto