Risk factors of retained products of conception after miscarriage or termination with gemeprost in the second trimester of pregnancy: a retrospective case-controlled study in Japanese population

Retained products of conception (RPOC) is a complication that occurs in the second trimester of pregnancy. We enrolled 98 women who had a miscarriage or termination with gemeprost in the second trimester of pregnancy. Eighteen cases (18.4%) were RPOC-positive. The gestational week at miscarriage or termination was earlier in the RPOC-positive group than those in the RPOC-negative group (p = .003). The period of the third stage of labour was longer in the RPOC-positive group than in RPOC-negative group (p = .040). The proportion of placental forceps use was higher in the RPOC-positive group than in RPOC-negative group (p = .003). Multivariate logistic regression analysis showed that gestational week (OR: 3.53; p = .04) and use of placental forceps at delivery (OR: 2.21; p = .012) were independent risk factors for RPOC. Earlier gestational weeks at miscarriage or termination and use of placental forceps at delivery were predictive factors for RPOC after second trimester miscarriage or termination with gemeprost.Impact Statement What is already known on this subject? There have been some reports on risk factors of RPOC. A previous report showed that the termination of pregnancy with misoprostol at earlier periods was associated with an increased risk of RPOC. What the results of this study add? There have been few studies on the risk factors of RPOC after miscarriage or termination with gemeprost. In this study, we evaluated the risk factors of RPOC after miscarriage or termination of pregnancy with gemeprost in the second trimester. We found that an earlier gestational age (between 12 and 17 weeks) at delivery and using placental forceps to remove placenta were significant risk factors of RPOC after miscarriage or termination of pregnancy with gemeprost in the second trimester. What the implications are of these findings for clinical practice and/or further research? An earlier gestational age and using forceps to remove placenta may be significant risk factors for RPOC. The accurate evaluation and treatment for RPOC is important for maternal life-saving efforts and subsequent pregnancies. Further research is needed to draft a standardised protocol for RPOC

Correlation between Post-Acute Electroconvulsive Therapy Alpha-Band Spectrum Power Increase and Improvement of Psychiatric Symptoms

The results of quantitative electroencephalography (qEEG) studies on electroconvulsive therapy (ECT) have been inconsistent, and indicators of the efficacy of ECT have not been clearly identified. In this study, we examined whether qEEG could be used as an indicator of the effect of ECT by measuring it during the course of treatment. We analyzed qEEG data before and after acute-phase ECT in 18 patients with schizophrenia, mood disorders, and other psychiatric disorders. We processed the qEEG data and compared the spectral power between the data acquired before and after ECT. The spectral power increased significantly after ECT in the delta, theta, and alpha bands. There was a strong significant correlation between the increase in the spectral power of the alpha band after acute ECT and improvement in the Brief Psychiatric Rating Scale score. Our results suggest that an increase in the alpha-band spectral power may be useful as an objective indicator of the treatment effect of acute ECT

Stretch-bend combination polyads in the Ã1Au [A tilde superscript 1 A subscript u] state of acetylene, C2H2 [C subscript 2 H subscript 2]

Rotational analyses are reported for a number of newly-discovered vibrational levels of the S1-trans [S subscriopt 1 -trans](Ã1Au) [A tilde superscript 1 A subscript u] state of C2H2 [C subscript 2 H subscript 2]. These levels are combinations where the Franck–Condon active v2' [v subscript 2 prime] and v3' [v subscript 3 prime] vibrational modes are excited together with the low-lying bending vibrations, v4' [v subscript 4 prime] and v6' [v subscript 6 prime]. The structures of the bands are complicated by strong a- and b-axis Coriolis coupling, as well as Darling–Dennison resonance for those bands that involve overtones of the bending vibrations. The most interesting result is the strong anharmonicity in the combinations of v3' [v subscript 3 prime] (trans bend, ag [a subscript g]) and v6' [v subscript 6 prime] (in-plane cis bend, bu [b subscript u]). This anharmonicity presumably represents the approach of the molecule to the trans–cis isomerization barrier, where ab initio results have predicted the transition state to be half-linear, corresponding to simultaneous excitation of v3' [v subscript 3 prime] and v6' [v subscript 6 prime]. The anharmonicity also causes difficulty in the least squares fitting of some of the polyads, because the simple model of Coriolis coupling and Darling–Dennison resonance starts to break down. The effective Darling–Dennison parameter, K4466 [K subscript 4466], is found to increase rapidly with excitation of v3' [v subscript 3 prime], while many small centrifugal distortion terms have had to be included in the least squares fits in order to reproduce the rotational structure correctly. Fermi resonances become important where the K-structures of different polyads overlap, as happens with the 2131B1 [2 superscript 1 3 superscript 1 B superscript 1] and 31B3 [3 superscript 1 B superscript 3] polyads (B = 4 or 6). The aim of this work is to establish the detailed vibrational level structure of the S1-trans [S subscript 1 -trans] state in order to search for possible S1-cis [S subscript 1 -cis] (1A2) [(superscript 1 A subscript 2)] levels. This work, along with results from other workers, identifies at least one K sub-level of every single vibrational level expected up to a vibrational energy of 3500 cm−1 [cm superscript -1].United States. Dept. of Energy (Grant DE-FG0287ER13671)Natural Sciences and Engineering Research Council of Canada (NSERC)National Science Council of Taiwa

Fig. S15 from Tumor-infiltrating Leukocyte Profiling Defines Three Immune Subtypes of NSCLC with Distinct Signaling Pathways and Genetic Alterations

Hazard ratios with deviation for specific signatures detected in the myeloid subtype of LUAD. The relationship between increased and decreased expression of signatures and event-free survival using transcriptome data from TCGA NSCLC was plotted. (a) hallmark gene set. (b) GO set.</p

Table S1 from Tumor-infiltrating Leukocyte Profiling Defines Three Immune Subtypes of NSCLC with Distinct Signaling Pathways and Genetic Alterations

Patient characteristics</p

TABLE 1 from Tumor-infiltrating Leukocyte Profiling Defines Three Immune Subtypes of NSCLC with Distinct Signaling Pathways and Genetic Alterations

Univariate and multivariate analyses of prognostic factors in LUAD and LUSQ</p

Fig. S6 from Tumor-infiltrating Leukocyte Profiling Defines Three Immune Subtypes of NSCLC with Distinct Signaling Pathways and Genetic Alterations

Relationship between the number of immune cell types and clinicopathological factors. Cells in the matrix represent the 1-Pearson correlation coefficient between cell density of the indicated immune cell composition and clinicopathological factors in LUAD (left) and LUSQ (right). * p<0.05.</p