Evolution of Cosmological Perturbation in Reheating Phase of the Universe

The evolution of the cosmological perturbation during the oscillatory stage of the scalar field is investigated. For the power law potential of the inflaton field, the evolution equation of the Mukhanov's gauge invariant variable is reduced to the Mathieu equation and the density perturbation grows by the parametric resonance.Comment: 10 pages, 1 figure

Somatotopic Organization of the Primate Basal Ganglia

Somatotopic organization is a fundamental and key concept to understand how the cortico-basal ganglia loop works. It is also indispensable knowledge to perform stereotaxic surgery for movement disorders. Here I would like to describe the somatotopic organization of the basal ganglia, which consist of the striatum, subthalamic nucleus, globus pallidus, and substantia nigra. Projections from motor cortical regions representing different body parts terminate in different regions of these nuclei. Basal ganglia neurons respond not only to the stimulation of the corresponding regions of the motor cortices, but also to active and passive movements of the corresponding body parts. On the basis of these anatomical and physiological findings, somatotopic organization can be identified in the motor territories of these nuclei in the basal ganglia. In addition, projections from functionally interrelated cortical areas partially converge through the cortico-basal ganglia loop, but nevertheless the somatotopy is still preserved. Disorganized somatotopy may explain, at least in part, the pathophysiology of movement disorders, such as Parkinson's disease and dystonia

Behavioral effects of zonisamide on L-DOPA-induced dyskinesia in Parkinson's disease model mice

Zonisamide (ZNS; 1,2-benzisoxazole-3-methanesulfonamide) was initially developed and is commonly used as an anticonvulsant drug. However, it has also shown its beneficial effects on Parkinson's disease (PD), a progressive neurodegenerative disorder caused by the loss of dopaminergic neurons in the midbrain. Recent clinical studies have suggested that ZNS can also have beneficial effects on L-DOPA-induced dyskinesia (LID), which is a major side effect of long-term L-DOPA treatments for PD. In the present study, we examined the behavioral effects of ZNS on LID in PD model mice. Acute ZNS treatment did not have any observable behavioral effects on LID. Contrastingly, chronic ZNS treatment with L-DOPA delayed the peak of LID and reduced the severity of LID before the peak but increased the duration of LID in a dose-dependent manner of ZNS compared to PD model mice treated with L-DOPA alone. Thus, ZNS appears to have both beneficial and adverse effects on LID

Solutions of gauge invariant cosmological perturbations in long-wavelength limit

We investigate gauge invariant cosmological perturbations in a spatially flat Friedman-Robertson-Walker universe with scalar fields. It is well known that the evolution equation for the gauge invariant quantities has exact solutions in the long-wavelength limit. We find that these gauge invariant solutions can be obtained by differentiating the background solution with respect to parameters contained in the background system. This method is very useful when we analyze the long-wavelength behavior of cosmological perturbation with multiple scalar fields.Comment: 17 pages, will appear in Classical and Quantum Gravit

Computational model of recurrent subthalamo-pallidal circuit for generation of parkinsonian oscillations

Parkinson’s disease is a movement disorder caused by dopamine depletion in the basal ganglia. Abnormally synchronized neuronal oscillations between 8 Hz and 15 Hz in the basal ganglia are implicated in motor symptoms of Parkinson’s disease. However, how these abnormal oscillations are generated and maintained in the dopamine-depleted state is unknown. Based on neural recordings in a primate model of Parkinson’s disease and other experimental and computational evidence, we hypothesized that the recurrent circuit between the subthalamic nucleus (STN) and the external segment of the globus pallidus (GPe) generates and maintains parkinsonian oscillations, and that the cortical excitatory input to the STN amplifies them. To investigate this hypothesis through computer simulations, we developed a spiking neuron model of the STN-GPe circuit by incorporating electrophysiological properties of neurons and synapses. A systematic parameter search by computer simulation identified regions in the space of the intrinsic excitability of GPe neurons and synaptic strength from the GPe to the STN that reproduce normal and parkinsonian states. In the parkinsonian state, reduced firing of GPe neurons and increased GPe-STN inhibition trigger burst activities of STN neurons with strong post-inhibitory rebound excitation, which is usually subject to short-term depression. STN neuronal bursts are shaped into the 8-15-Hz, synchronous oscillations via recurrent interactions of STN and GPe neurons. Furthermore, we show that cortical excitatory input to the STN can amplify or suppress pathological STN oscillations depending on their phase and strength, predicting conditions of cortical inputs to the STN for suppressing oscillations

E-Healthcare at an Experimental Welfare Techno House in Japan

An automated monitoring system for home health care has been designed for an experimental house in Japan called the Welfare Techno House (WTH). Automated electrocardiogram (ECG) measurements can be taken while in bed, in the bathtub, and on the toilet, without the subject’s awareness, and without using body surface electrodes. In order to evaluate this automated health monitoring system, overnight measurements were performed to monitor health status during the daily lives of both young and elderly subjects

Chemical effect on muonic atom formation through muon transfer reaction in benzene and cyclohexane samples

To investigate the chemical effect on the muon capture process through a muon transfer reaction from a muonic hydrogen atom, the formation rate of muonic carbon atoms is measured for benzene and cyclohexane molecules in liquid samples. The muon transfer rate to carbon atoms of the benzene molecule is higher than that to the carbon atoms of the cyclohexane molecule. Such a deviation has never been observed among those molecules for gas samples. This may be because the transfers occur from the excited states of muonic hydrogen atoms in the liquid system, whereas in the gas system, all the transfers occur from the 1s (ground) state of muon hydrogen atoms. The muonic hydrogen atoms in the excited states have a larger radius than those in the 1s state and are therefore considered to be affected by the steric hindrance of the molecular structure. This indicates that the excited states of muonic hydrogen atoms contribute significantly to the chemical effects on the muon transfer reaction

Lattice Study of Low-lying Nonet Scalar Mesons in Quenched Approximation

Using lattice QCD simulation in the quenched approximation, we study the $\kappa$ meson, which is ^3P_0 in the quark model, and compare experimental and other lattice data. The $\kappa$ is the lowest scalar meson with strangeness and constitutes the scalar nonet. The obtained mass is much higher than the recent experimental value, and therefore the $\kappa(800)$ is difficult to consider as a simple two-body constituent-quark structure, and may have another unconventional structure.Comment: 11pages, 5figure