17 research outputs found
Human factors for dementia: Evidence based design
Designing care environments for people living with dementia is a complex challenge as the key stakeholder may have difficulty communicating their capabilities, limitations and preferences. This paper describes the use of evidence-based design personas in a multi-disciplinary team with architects and chartered human factors specialists. Four individual personas (Alison, Barry, Christine and David) and a couple persona (Chris and Sally) were used to bring the voices of the people living with different stages of dementia to the design process. Their changing/fluctuating symptoms were communicated in two formats (wheel and matrix) within an inclusive design process to adapt a Victorian semi-detached house. The demonstrator house presents evidence based design, adaptation and support solutions to support people living with dementia to age well at home
Environmental issues related to visibility and consumption of food in an Alzheimer's disease unit
Environmental Interventions and the Design of Homes for Older Adults With Dementia: An Overview
FRACTAL-BASED ANALYSIS OF THE RELATION BETWEEN THE FRACTAL STRUCTURES OF MACHINED SURFACE AND TOOL WEAR IN TURNING OPERATION
Effects of reminiscence group in elderly people with Alzheimer disease and vascular dementia in a community setting
Treatment Strategies for the Behavioral Symptoms of Alzheimer's Disease: Focus on Early Pharmacologic Intervention
A continuum mechanics model of enzyme-based tissue degradation in cancer therapies
We propose a mathematical model to describe enzyme-based tissue degradation in cancer therapies. The proposed model combines the poroelastic theory of mixtures with the transport of enzymes or drugs in the extracellular space. The effect of the matrix degrading enzymes on the tissue composition and its mechanical response are accounted for. Numerical simulations in 1D, 2D and ax-isymmetric (3D) configurations show how an injection of matrix degrading enzymes alters the porosity of a biological tissue. We eventually exhibit numerically the main consequences of a matrix degrading enzyme pretreatment in the framework of chemotherapy: the removal of the diffusive hindrance to the penetration of therapeutic molecules in tumors and the reduction of interstitial fluid pressure which improves transcapillary transport. Both effects are consistent with previous biological observations