Designing an Organizational Performance Model Based on the Digital Status of the Organization During the Covid-19 outbreak in the Ministry of Industry, Mine and Trade

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A national school-based screening program for mental health problems among children aged 6 to 12 years in Iran:scale development and psychometric evaluation

Schools are an ideal setting in which to measure and promote mental health difficulties. The aim of present study was to develop the Nemad Electronic Mental-Health Assessment Devices for Children (NEMAD-C) aged 6 to 12 years in Iran. A sample of parents and teachers (N = 10,163) were recruited to complete the parent and teacher reports. Totally, explorative and confirmatory factor analyses showed that the eight-factor model provides a better fit for both parental report and teacher report versions. Results revealed a screening tool consisting of eight dimensions: child abuse risk, self-harm, anxiety, depression, disruptive behavior disorders, attention deficit/hyperactivity disorders, academic achievement deficit, and self-regulation. Findings showed that the internal consistency coefficients of the subscales were high, and convergent validity was evidenced by significant correlations with theoretically related constructs. Therefore, the NEMAD-C has adequate reliability and validity and could be used for multi-dimensional assessment of mental health problems in Iran

Presenting and Explaining the Organizational Performance Model Based on the Digital Status of the Organization in the Corona Eera with the Foundation Data Approach in the Ministry of Samt

Digital transformation, which has always been important as a fundamental and strategic action in organizations, has become more important in recent years following the outbreak of coronavirus and the pressures of the coronavirus epidemic have accelerated the efforts of organizations to create digital transformation. The purpose of this study is to design an organizational performance model based on the digital status of the organization in the Corona era with the data foundation approach in the Ministry of Silence. This research was conducted with a qualitative-inductive approach and the method of Strauss-Corbin contextual theory. The research tool (data collection) was a semi-structured interview. Using the grounded theory method, the data obtained from interviews with 27 elites and qualified specialists of the Ministry of Silence were analyzed in three stages of open, axial, and selective coding. 18 general categories in the form of a paradigm model in which these factors include causal conditions (individual factors, organizational factors, technological factors, and environmental factors) central phenomenon (digital status of the organization), underlying conditions (digital context, management context, individual context, technology context), conditions Intervener (individual factors, cultural factors, and organizational factors) and strategies (individual strategy, managerial strategy, and organizational strategy) and consequences (individual results, organizational results, and social results)

Comparative Study of Serum levels of Granzyme H & Estrogen In Patients Suffering From Breast Cancer

GranymeH is a functional cytotoxic serine protease of NK cell granules,which expands the cell death-inducing repertoire of innate immune system.The purpose of this study was to determine GranymeH(GZMH)level in breast cancer(BC) and healty women.This study was performed on 30 patients with BC and 30 healty woman.GZMH and Estrogen levels were measured in cancer patients  and healty women subsequently using ELISA and Radioimmunoassay(RIA) methods. Mean GZMH value was lower in BC than healty women(p<0.0001) and  mean Estrogen level was  higher  in BC patients  in comparison to healty women (p<0.003).Our finding indicates probability of existance of suppressor or a problem in production of GZMH in cancer patient

Evaluation of the relationship between serumsVisfatin and Resistin levels with BMI in PCOS young women

Polycystic ovary syndrome (PCOS) is a common endocrine / metabolic disorder in women of reproductive age .Abdominal adiposity and obesity are frequently present in PCOS. It now appears that, obesity is associated with a low-grade inflammation of white adipose tissue.Adipokines play a significant role in the pathogenesis of a low-grade inflammation associated with obesity. Among variety of adipokines, resistin and visfatin are proposed as important pro inflammatory mediators and they have recently been suggested to be associated with obesity related diseases.The aim of this study is to evaluate the correlation of visfatin and resistin serum levels and the ratio of these two adipokines with BMI in PCOS women under age of 35 years old. Twenty eight young women with clinically confirmed PCOS disease (14 lean and 14 obese), and 12 young, healthy and lean women with stable weight and BMI<25 were enrolled. Blood was obtained from the included persons, and visfatin and resistin were assessed by ELISA method. We did not observe any significant differences in serum visfatin and resistin concentrations and also in the Visfatin/Resistin ratio between PCOS and control group. Also we did not found a significant correlation between visfatin and resistin with BMI. This study demonstrated that serum resistin and visfatin levels do not seem to be directly involved in the pathology of PCOS

Anti –MBP autoantibody changes as a predictor of response to treatment in MS patients

Myelin basic protein (MBP) is one of the most important constituents of the CNS myelin sheaths. It is supposed that an autoimmune response directed against MBP is crucial in the demyelination process in patients with multiple sclerosis. Studies have proved that free anti-MBP level in CSF of MS patients is declined when the patient entered into clinical remission. Some researchers evaluate the changes in serum or CSF level of this antibody during immunomodulatory therapy; the results are different and the relation between the changes in this antibody and response to treatment is poorly investigated. The objective of this study was to assess the relation between the changes in serum level of anti-MBP and clinical remission in patients during treatment with fingolimod. 37 MS patients that were non responder to interferon and glatiramer acetate and were candidates to receive fingolimod were nominated for this study.  In this study, the serum level of anti-MBP was evaluated before and after 3 and 6 months of therapy and clinical remission was assessed by changes in Expanded Disability Status Scale (EDSS) scores. The result of this study showed that MS patients, after treatment with interferon, have lower serum anti-MBP level than healthy control group and this difference is statistically significant (p =0.03).  The present study demonstrated that the serum anti-MBP level in MS patient during 6 months of treatment with fingolimod significantly decreased (p<0.001). However, there was no significant difference in EDSS of MS patients during 6 months of treatment with fingolimod ( p < 0.001)

Comparative study of serum levels of Perforin in Prostate Cancer and Benign Prostatic Hyperplasia patients

Perforin(p) is the primary mediator of short term cytotoxicity, it is accumulated in response to proinflammatory  cytokines and stored in T lymphocyte , NK cells and NKT cells are released upon activation. Perforin is a prototypical cytotoxic molecule involved in cell mediated immunity against various pathogens , alloantigens and particularly different tumors.The purpose of this study was to determine perforin level in prostate cancer (P.Ca) and Benign Prostatic Hyperplasia (BPH) This is study was performed on 59 patients consisting of 28 patients with P.Ca and 31 patients with BPH.Perforin and PSA levels were measured in cancer and BPH patients  using ELISA method.   Mean Perforin value was significantly lower in P.Ca patients than in BPH patients ( p < 0.01)  where as mean serum PSA level was significantly higher in the cancer patients in comparison to the BPH group (P < 0.01 Our finding indicate probability of problem in expression of cytotoxic molecule ,perforin in and around the tumor

Network-based analysis of differentially expressed genes in cerebrospinal fluid (CSF) and blood reveals new candidate genes for multiple sclerosis

Background The involvement of multiple genes and missing heritability, which are dominant in complex diseases such as multiple sclerosis (MS), entail using network biology to better elucidate their molecular basis and genetic factors. We therefore aimed to integrate interactome (protein–protein interaction (PPI)) and transcriptomes data to construct and analyze PPI networks for MS disease. Methods Gene expression profiles in paired cerebrospinal fluid (CSF) and peripheral blood mononuclear cells (PBMCs) samples from MS patients, sampled in relapse or remission and controls, were analyzed. Differentially expressed genes which determined only in CSF (MS vs. control) and PBMCs (relapse vs. remission) separately integrated with PPI data to construct the Query-Query PPI (QQPPI) networks. The networks were further analyzed to investigate more central genes, functional modules and complexes involved in MS progression. Results The networks were analyzed and high centrality genes were identified. Exploration of functional modules and complexes showed that the majority of high centrality genes incorporated in biological pathways driving MS pathogenesis. Proteasome and spliceosome were also noticeable in enriched pathways in PBMCs (relapse vs. remission) which were identified by both modularity and clique analyses. Finally, STK4, RB1, CDKN1A, CDK1, RAC1, EZH2, SDCBP genes in CSF (MS vs. control) and CDC37, MAP3K3, MYC genes in PBMCs (relapse vs. remission) were identified as potential candidate genes for MS, which were the more central genes involved in biological pathways. Discussion This study showed that network-based analysis could explicate the complex interplay between biological processes underlying MS. Furthermore, an experimental validation of candidate genes can lead to identification of potential therapeutic targets