163 research outputs found
Pregnancy-related knowledge, risk perception, and reproductive decision making of women with epilepsy in Korea
AbstractPurposeTo determine the influence of pregnancy-related knowledge and the risk perception on reproductive decision making in women with epilepsy.MethodsWe enrolled women with epilepsy, who were of reproductive age and were considering having children in the future. A questionnaire was used to assess the level of pregnancy-related knowledge, perception of the offspring's risk for developing epilepsy or for having a congenial anomaly, and discussion with a physician concerning pregnancy-related issues. We evaluated the following outcome variables: (1) the decision to discontinue anti-epileptic drug (AED) during a future pregnancy regardless of the medical indication; and (2) the decision to have fewer children because of epilepsy.ResultsWe enrolled a total of 186 women with epilepsy. (1) Fifty-eight percent of the women were considering discontinuing AED during a future pregnancy regardless of the medical indication, and 25% of the women decided to have fewer children because of epilepsy. (2) The decision to discontinue AED during a future pregnancy was associated with low-level pregnancy-related knowledge. (3) The decision to have fewer children because of epilepsy was associated with an exaggerated perception of the offspring's risk for developing epilepsy. (4) The women who had ever discussed pregnancy-related issues with their physician were less likely to decide to discontinue AED during a future pregnancy; however, a discussion on this issue had no impact on their decision to have fewer children because of epilepsy.ConclusionMore than 50% of the women would decide to discontinue AED during a future pregnancy, and 25% of the women stated that they would have fewer children because of epilepsy. These data highlight the importance of education on pregnancy-related issues and genetic risk counseling
Interval from Prostate Biopsy to Robot-Assisted Laparoscopic Radical Prostatectomy (RALP): Effects on Surgical Difficulties
The East Asian Journal of British History, vol. 2
The East Asian Journal of British History is produced by the East Asian Society of British History, and supported by the Institute for Historical Research.
The Institute of Historical Research is pleased and proud to be supporting this recent addition to British history scholarship. Developing out of the IHRâs long-standing collaborative partnership with Japanese universities, and now in its fourth year, the East Asian Journal of British History features some of the best emergent scholarship from Anglophone historians working in China, Japan, and South Korea.
Divided between an articles section and one devoted to reviews, the journalâs remit wide-ranging covering all fields and periods of British history. It complements the triennial Anglo-Japanese Conference organised by the IHR and Japanese historians based at the universities of Tokyo, Kyoto and Osaka, and the conference of the East Asian Society of British history, in which we are joined by our colleagues from South Korea. In future, we hope that more contributions will be featured in the journal from the Chinese mainland and from Taiwan
Carotid artery intima-media thickness in Behcet's disease patients without significant cardiovascular involvement
Aseptic Endocarditis in Behçet's Disease Presenting as Tricuspid Valve Stenosis
Aseptic endocarditis is an uncommon complication of Behçet's disease (BD). We describe a rare case of a 39-year-old female who had BD with aseptic endocarditis of the tricuspid valve (TV) presenting as tricuspid stenosis. She was diagnosed with BD four years ago. The mucocutaneous lesions were well-controlled with colchicine and short courses of corticosteroids. She remained free of signs and symptoms of BD for one year without any medication. Three months before admission, she gradually developed dyspnea on exertion and peripheral edema. Echocardiography revealed dilated right atrium and markedly thickened TV with severe stenosis. TV replacement was performed. Pathologic examination of the valve showed fibrinoid necrotic material and inflammatory cell infiltration. Blood cultures and cultures of the excised valve were negative for microorganisms
A framework for nationwide COVID-19 vaccine safety research in the Republic of Korea: the COVID-19 Vaccine Safety Research Committee
With the introduction of coronavirus disease 2019 (COVID-19) vaccines, the Korea Disease Control and Prevention Agency (KDCA) commissioned the National Academy of Medicine of Korea to gather experts to independently assess post-vaccination adverse events. Accordingly, the COVID-19 Vaccine Safety Research Committee (CoVaSC) was launched in November 2021 to perform safety studies and establish evidence for policy guidance. The CoVaSC established 3 committees for epidemiology, clinical research, and communication. The CoVaSC mainly utilizes pseudonymized data linking KDCAâs COVID-19 vaccination data and the National Health Insurance Serviceâs claims data. The CoVaSCâs 5-step research process involves defining the target diseases and organizing ad-hoc committees, developing research protocols, performing analyses, assessing causal relationships, and announcing research findings and utilizing them to guide compensation policies. As of 2022, the CoVaSC completed this research process for 15 adverse events. The CoVaSC launched the COVID-19 Vaccine Safety Research Center in September 2022 and has been reorganized into 4 divisions to promote research including international collaborative studies, long-/short-term follow-up studies, and education programs. Through these enhancements, the CoVaSC will continue to swiftly provide scientific evidence for COVID-19 vaccine research and compensation and may serve as a model for preparing for future epidemics of new diseases
Prevalence of Anti-Ganglioside Antibodies and Their Clinical Correlates with Guillain-Barre Syndrome in Korea: A Nationwide Multicenter Study
Background and Purpose No previous studies have investigated the relationship between various anti-ganglioside antibodies and the clinical characteristics of Guillain-Barre syndrome (GBS) in Korea. The aim of this study was to determine the prevalence and types of anti-ganglioside antibodies in Korean GBS patients, and to identify their clinical significance. Methods Serum was collected from patients during the acute phase of GBS at 20 university-based hospitals in Korea. The clinical and laboratory findings were reviewed and compared with the detected types of anti-ganglioside antibody. Results Among 119 patients, 60 were positive for immunoglobulin G (IgG) or immunoglobulin M antibodies against any type of ganglioside (50%). The most frequent type was IgG anti-GM1 antibody (47%), followed by IgG anti-GT1a (38%), IgG anti-GD1a (25%), and IgG anti-GQ1b (8%) antibodies. Anti-GM1-antibody positivity was strongly correlated with the presence of preceding gastrointestinal infection, absence of sensory symptoms or signs, and absence of cranial nerve involvement. Patients with anti-GD1a antibody were younger, predominantly male, and had more facial nerve involvement than the antibody-negative group. Anti-GT1a-antibody positivity was more frequently associated with bulbar weakness and was highly associated with ophthalmoplegia when coupled with the coexisting anti-GQ1b antibody. Despite the presence of clinical features of acute motor axonal neuropathy (AMAN), 68% of anti-GM1- or anti-GD1a-antibody-positive cases of GBS were diagnosed with acute inflammatory demyelinating polyradiculoneuropathy (AMP) by a single electrophysiological study. Conclusions Anti-ganglioside antibodies were frequently found in the serum of Korean GBS patients, and each antibody was correlated strongly with the various clinical manifestations. Nevertheless, without an anti-ganglioside antibody assay, in Korea AMAN is frequently misdiagnosed as AIDP by single electrophysiological studies.OAIID:oai:osos.snu.ac.kr:snu2014-01/102/0000004487/14SEQ:14PERF_CD:SNU2014-01EVAL_ITEM_CD:102USER_ID:0000004487ADJUST_YN:YEMP_ID:A075641DEPT_CD:801CITE_RATE:1.807FILENAME:kimjk-anti ganlioside ab-gbs-j clin neurol-2014-10(2)94.pdfDEPT_NM:ěíęłźSCOPUS_YN:YCONFIRM:
Evaluation of synbiotics as gut health improvement agents against Shiga toxin-producing Escherichia coli isolated from the pig
Colibacillosis is one of the major health problems in young piglets resulting in
poor health and death caused by Escherichia coli producing F18
pili and Shiga toxin 2e. It is pivotal to reduce colibacillosis in weaned
piglets to enhance production performance. In this study, we evaluated
synbiotics as the gut health improvement agents in the mouse model challenged
with Shiga toxin-producing E. coli (STEC) isolated from
piglets. Prebiotic lactulose was formulated with each 5.0 Ă
106 CFU/mL of Pediococcus acidilactici GB-U15,
Lactobacillus plantarum GB-U17, and Lactobacillus
plantarum GB 1-3 to produce 3 combinations of synbiotics. A total
of 40 three weeks old BALB/c mice were randomly assigned to 4 groups (n =
10): a control group and 3 synbiotics treated groups. Each treatment groups were
daily administrated with 5.0 Ă 106 CFU/mL of one synbiotics
for the first week, and every 3 days during the second week. All the mice were
challenged with 8.0 Ă 108 CFU/mL of STEC 5 days after animals
began to receive synbiotics. Mice treated with synbiotics based on
Pediococcus acidilactici GB-U15 and Lactobacillus
plantarum GB-U17 significantly improved daily weight gain compared
to mice in other groups. While mice treated with GB-U15 showed better fecal
index, no significant differences were observed among groups. Gross lesion and
histopathological evaluations showed that mice treated with GB-U15 moderately
improved recovery from STEC infection. In conclusion, our results suggest that
the synbiotics formulated with lactulose and Pediococcus
acidilactici GB-U15 have potential benefits to prevent and improve
colibacillosis in weaned piglets
Evaluation of circumsporozoite protein of Plasmodium vivax to estimate its prevalence in the Republic of Korea: an observational study of incidence
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