Exploring Current Trends and Challenges in Cybersecurity: A Comprehensive Survey

Cyber security is the process of preventing unauthorized access, theft, damage, and interruption to computers, servers, networks, and data. It entails putting policies into place to guarantee the availability, confidentiality, and integrity of information and information systems. Cyber security seeks to protect against a variety of dangers, including as hacking, data breaches, malware infections, and other nefarious actions.  Cyber security has grown to be a major worry as a result of the quick development of digital technology and the growing interconnection of our contemporary society. In order to gain insight into the constantly changing world of digital threats and the countermeasures put in place to address them, this survey seeks to study current trends and issues in the area of cyber security. The study includes responses from end users, business executives, IT administrators, and experts across a wide variety of businesses and sectors. The survey gives insight on important problems such the sorts of cyber threats encountered, the efficacy of current security solutions, future technology influencing cyber security, and the human elements leading to vulnerabilities via a thorough analysis of the replies. The most important conclusions include an evaluation of the most common cyber dangers, such as malware, phishing scams, ransom ware, and data breaches, as well as an investigation of the methods and tools used to counter these threats. The survey explores the significance of staff education and awareness in bolstering cyber security defenses and pinpoints opportunities for development in this area. The survey also sheds insight on how cutting-edge technologies like cloud computing, artificial intelligence, and the Internet of Things (IoT) are affecting cyber security practices. It analyses the advantages and disadvantages of using these technologies while taking into account issues like data privacy, infrastructure security, and the need for specialized skills. The survey also looks at the compliance environment, assessing how industry norms and regulatory frameworks affect cyber security procedures. The survey studies the obstacles organizations encounter in attaining compliance and assesses the degree of knowledge and commitment to these requirements. The results of this cyber security survey help to better understand the current status of cyber security and provide organizations and individual’s useful information for creating effective policies to protect digital assets. This study seeks to promote a proactive approach to cyber security, allowing stakeholders to stay ahead of threats and build a safe digital environment by identifying relevant trends and concerns

O 2 Reduction on Graphite and Nitrogen-Doped Graphite: Experiment and Theory

An experimental and theoretical study of electroreduction of oxygen to hydrogen peroxide is presented. The experimental measurements of nitrided Ketjenblack indicated an onset potential for reduction of approximately 0.5 V (SHE) compared to the onset potential of 0.2 V observed for untreated carbon. Quantum calculations on cluster models of nitrided and un-nitrided graphite sheets show that carbon radical sites formed adjacent to substitutional N in graphite are active for O 2 electroreduction to H 2 O 2 via and adsorbed OOH intermediate. The weak catalytic effect of untreated carbon is attributed to weaker bonding of OOH to the H atom-terminated graphite edges. Substitutional N atoms that are far from graphite sheet edges will be active, and those that are close to the edges will be less active. Interference from electrochemical reduction of H atoms on the reactive sites is considered, and it is shown that in the potential range of H 2 O 2 formation the reactive sites are not blocked by adsorbed H atoms

Atomic-resolution spectroscopic imaging of ensembles of nanocatalyst particles across the life of a fuel cell

The thousandfold increase in data-collection speed enabled by aberration-corrected optics allows us to overcome an electron microscopy paradox - how to obtain atomic-resolution chemical structure in individual nanoparticles, yet record a statistically significant sample from an inhomogeneous population. This allowed us to map hundreds of Pt-Co nanoparticles to show atomic-scale elemental distributions across different stages of the catalyst aging in a proton-exchange-membrane fuel cell, and relate Pt-shell thickness to treatment, particle size, surface orientation, and ordering.Comment: 28 pages, 5 figures, accepted, nano letter

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

A review on gasification of biomass

Studies on the effect of size, structure, environment, temperature, heating rate, composition of biomass and ash are reviewed. Based on the observations reported so far, auto-gasification of biomass by the bio-oxygen and the catalytic ash would be feasible. The auto-gasification may be explained in terms of heterogeneous catalytic reaction. Better understanding of auto-gasification is possible by further studies carrying out on the effect of heating rate on auto-gasification.Gasification Pyrolysis TGA Catalytic ash

Integrated Analysis of Dysregulated miRNA-Gene Expression in -Silenced Retinoblastoma Cells

Retinoblastoma (RB) is a primary childhood eye cancer. HMGA2 shows promise as a molecule for targeted therapy. The involvement of miRNAs in genome-level molecular dys-regulation in HMGA2 -silenced RB cells is poorly understood. Through miRNA expression microarray profiling, and an integrated array analysis of the HMGA2 -silenced RB cells, the dysregulated miRNAs and the miRNA-target relationships were modelled. Loop network analysis revealed a regulatory association between the transcription factor ( SOX5 ) and the deregulated miRNAs imiR-29a, miR-9*, miR-9-3 ). Silencing of HMGA2 deregulated the vital oncomirs ( miR-7, miR-331, miR-26a, miR-221, miR-17∼92 and miR-106b∼25 ) in RB cells. From this list, the role of the miR-106b∼25 cluster was examined further for its expression in primary RB tumor tissues (n = 20). The regulatory targets of miR-106b∼25 cluster namely p21 (cyclin-dependent kinase inhibitor) and BIM (pro-apoptotic gene) were elevated, and apoptotic cell death was observed, in RB tumor cells treated with the specific antagomirs of the miR-106b∼25 cluster. Thus, suppression of miR-106b∼25 cluster controls RB tumor growth. Taken together, HMGA2 mediated anti-tumor effect present in RB is, in part, mediated through the miR-106b∼25 cluster

Efficacy of DCBT 2345 - an ayurvedic compound in treatment of type 2 diabetic patients with secondary failure to oral drugs - randomized double blind placebo control study

The objective of this study was to determine the efficacy of DCBT 2345 - an ayurvedic compound, in the management of diabetes of type 2 diabetic patients with secondary failure to oral hypoglycemic agents. A randomized, double blind, single center study of six months duration was carried out. 44 type 2 diabetic patients who satisfied the inclusion criteria were recruited for the study. Out of 44 patients, 30 completed the trial. 15 in the DCBT 2345 arm and 15 in the placebo arm. End points of the study included fasting and post prandial plasma glucose and glycosylated hemoglobin levels. There was no significant reduction in the fasting and postprandial plasma glucose levels in both the groups (placebo and DCBT 2345). However there was a significant reduction in the glycosylated hemoglobin levels (p = 0.037) in the DCBT 2345 group. No adverse events were noted in patients treated with DCBT 2345. Our study suggest that DCBT 2345 exerts a mild hypoglycemic action in type 2 diabetic patients with secondary failure to oral hypoglycemic agents

Estimation of thyroglobulin in lymph node aspirates: Pilot experience from a tertiary referral cancer center

Background: Assessment of cervical lymph node involvement in patients with thyroid cancer either during preoperative surgical mapping or detection of recurrences during follow-up is a crucial step in the management of differentiated thyroid cancers (DTCs). In most patients, fine needle aspiration cytology (FNAC) confirms the presence of metastasis in lymph node. However, in cases of paucicellular lymph node aspirate or discordant sonogram and cytology results, thyroglobulin (Tg) measurement in the lymph node aspirate (FNA-Tg) is useful and a value >1 ng/ml is considered consistent with metastatic disease. Context: The addition of FNAC to the US improves the specificity, but 5–10% are nondiagnostic and 6–8% rate of false-negative results. Several studies have reported that the detection of Tg in FNA-needle washes improves the evaluation of suspicious lymph nodes in patients with DTC.Data from Indian centers on FNA-Tg are limited. Aims: We piloted the utility of FNA-Tg in patients with sonographically suspicious cervical lymph node enlargement in the setting of suspicious thyroid nodule or in the follow-up of thyroid cancer. Settings and Design: Prospective data collection. Results: We measured Tg in 13 lymph node aspirates (12 patients, 10 females) among whom 4 patients had a total thyroidectomy and 1 had a hemithyroidectomy. Eight of the 13 lymph node aspirates had FNA-Tg values >150 ng/ml, all of them had unequivocal malignant cytology and four among them had proven metastatic DTC on surgical pathology. The median FNA-Tg of the patients with malignant cytology was 7550 ng/ml with a range of 162–30,000 ng/ml. Among the remaining 5 lymph node aspirate, 2 lymph nodes showed cytological features suggestive of reactive lymphadenitis (FNA-Tg <0.2 ng/ml) and were not operated, 1 had a high-grade malignancy consistent with anaplastic thyroid cancer (FNA-Tg <0.2 ng/ml), and 2 had nondiagnostic cytology (one had non-caseating granuloma on surgical pathology [FNA-Tg 1.3 ng/ml] and in the other patient [FNA-Tg <0.2 ng/ml] surgical intervention was deferred). Conclusions: FNA-Tg was concordant with positive cytology in all patients with DTC and may serve as a useful tool in patients with negative and nondiagnostic cytology to guide surgical management

Assess the Attitude Towards Mental Illness Among Nurses Working in Selected Tertiary Care Hospital

Mental health is an urgent concern in India as every sixth Indian needs mental health help as reported by a recent National Mental Health Survey done by Gururaj in the year 2016. Further, while 20% of Indians suffer from a mental illness, only 10-12% of them seek help from mental health professionals mainly due to ignorance, stigma and discrimination that largely prevail in Indian community. The study aimed to assess the attitude towards mental illness among nurses and to associate the attitude towards mental illness among nurses working in selected tertiary care hospitals with background selected variables. A non-experimental descriptive research design was used in this study. A purposive sampling technique was used to select the samples and 400 samples were taken for the study. The majority of the nurses have negative 310 (77%) attitudes towards mental illness and only 90(23%) of them have positive attitudes towards mental illness. The mean value of attitude is 59.59 with a standard deviation of 4.94. There is no significant association was found between attitudes toward mental illness among nurses working in selected tertiary care hospitals with background variables at p<0.05. The study results recommend initiating training programs for the nurses aimed at promoting positive attitudes and making them sensitive to the needs of mentally ill patients