Related and unrelated industry variety and the internationalization of start-ups

We study the relationship between industry variety in a start-up's home location and the start-up's internationalization in terms of both the likelihood of and persistence in exporting. Using a unique sample of Swedish start-ups, we find that related industry variety is positively associated with exporting likelihood and persistence, whereas unrelated industry variety is positively associated with exporting likelihood and persistence when the start-ups’ employees possess technological knowledge. We also find that employees’ international experience strengthens the positive relationship between related industry variety and start-ups’ export persistence. We provide auxiliary evidence of the proposed mechanisms through which related and unrelated industry variety affects start-ups’ internationalization—that is, through their effects on start-ups’ ability to launch novel products in foreign markets. The findings of our study provide policymakers preliminary evidence on th

The role of collaboration and external knowledge for innovation in small food firms

In this study, we use unique purpose-built survey data to show that small food firms are more innovative when externally engaged. To capture this, we apply a broad classification of innovative activities, including new products, processes, markets, organization, and distribution channels, and examine them against types of external interactions. The analysis, an ordered logit estimation, controls for heterogeneity across firms as well as geographic conditions. The results demonstrate a positive relationship between external interaction and firm innovation, though there are differences across types of external engagement and innovation activities. Product innovation benefits from knowledge from extra-regional firms, while several of the other forms of innovation show a positive relationship with support from regional and municipality boards. Additionally, firm collaboration regarding transports and sales enhances most types of innovation, but there are few relationships of benefit with research-intensive organizations. We conclude that, to be effective, innovation strategies of both the firms themselves and policymakers need to consider local context, access to intra- and extra-regional knowledge sources, and what types of innovation activities the firms are engaged in

Related and unrelated industry variety and the internationalization of start-ups

We study the relationship between industry variety in a start-up's home location and the start-up's internationalization in terms of both the likelihood of and persistence in exporting. Using a unique sample of Swedish start-ups, we find that related industry variety is positively associated with exporting likelihood and persistence, whereas unrelated industry variety is positively associated with exporting likelihood and persistence when the start-ups’ employees possess technological knowledge. We also find that employees’ international experience strengthens the positive relationship between related industry variety and start-ups’ export persistence. We provide auxiliary evidence of the proposed mechanisms through which related and unrelated industry variety affects start-ups

Timeout : The Role of Family-Friendly Policies in Business Start-Up Among Mothers

This article explores why an increasing number of Swedish mothers are becoming entrepreneurs; this choice appears counterintuitive given the prevailing social welfare system prioritizes the rights of employed women. Using an interpretative stance, we analyzed the life stories of 18 Swedish mothers who created new ventures while caring for young children. The value of the time afforded by parental leave policies was identified as vital to the business creation process. Hence, we argue that time is a critical entrepreneurship-relevant resource; this is illustrated by the positive effect of the Swedish welfare system upon entrepreneurship entry and the timing of this decision

Double-blind placebo-controlled randomized clinical trial on the efficacy of Aerosal® in the treatment of sub-obstructive adenotonsillar hypertrophy and related diseases

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Agreement on classification of clinical photographs of pigmentary lesions: exercise after a training course with young dermatologists.

Smartphone apps may help promoting the early diagnosis of melanoma. The reliability of specialist judgment on lesions should be assessed. Hereby, we evaluated the agreement of 6 young dermatologists, after a specific training. Clinical judgment was evaluated during 2 online sessions, 1 month apart, on a series of 45 pigmentary lesions. Lesions were classified as highly suspicious, suspicious, non-suspicious or not assessable. Cohen's and Fleiss' kappa were used to calculate intra- and inter-rater agreement. The overall intra-rater agreement was 0.42 (95% confidence interval - CI: 0.33-0.50), varying between 0.12-0.59 on single raters. The inter-rater agreement during the first phase was 0.29 (95% CI: 0.24-0.34). When considering the agreement for each category of judgment, kappa varied from 0.19 for not assessable to 0.48 for highly suspicious lesions. Similar results were obtained in the second exercise. The study showed a less than satisfactory agreement among young dermatologists. Our data point to the need for improving the reliability of the clinical diagnoses of melanoma especially when assessing small lesions and when dealing with thin melanomas at a population level

The still under-investigated role of cognitive deficits in PML diagnosis

Background: Despite cognitive deficits frequently represent the first clinical manifestations of Progressive Multifocal Leukoencephalopathy (PML) in Natalizumab-treated MS patients, the importance of cognitive deficits in PML diagnosis is still under-investigated. The aim of the current study is to investigate the cognitive deficits at PML diagnosis in a group of Italian patients with PML. Methods: Thirty-four PML patients were included in the study. The demographic and clinical data, the lesion load and localization, and the longitudinal clinical course was compared between patients with (n = 13) and without (n = 15) cognitive deficit upon PML suspicion (the remaining six patients were asymptomatic). Clinical presentation of cognitive symptoms was described in detail. Result: After symptoms detection, the time to diagnosis resulted to be shorter for patients presenting with cognitive than for patients with non cognitive onset (p = 0.03). Within patients with cognitive onset, six patients were presenting with language and/or reading difficulties (46.15%); five patients with memory difficulties (38.4%); three patients with apraxia (23.1%); two patients with disorientation (15.3%); two patients with neglect (15.3%); one patients with object agnosia (7.7%), one patient with perseveration (7.7%) and one patient with dementia (7.7%). Frontal lesions were less frequent (p = 0.03), whereas temporal lesions were slightly more frequent (p = 0.06) in patients with cognitive deficits. The longitudinal PML course seemed to be more severe in cognitive than in non cognitive patients (F = 2.73, p = 0.03), but differences disappeared (F = 1.24, p = 0.29) when balancing for the incidence of immune reconstitution syndrome and for other treatments for PML (steroids, plasma exchange (PLEX) and other therapies (Mefloquine, Mirtazapine, Maraviroc). Conclusion: Cognitive deficits at PML onset manifest with symptoms which are absolutely rare in MS. Their appearance in MS patients should strongly suggest PML. Clinicians should be sensitive to the importance of formal neuropsychological evaluation, with particular focus on executive function, which are not easily detected without a formal assessment

Building a rheumatology biobank for reliable basic/translational research and precision medicine

Research biobanks are non-profit structures that collect, manipulate, store, analyze and distribute systematically organized biological samples and data for research and development purposes. Over the recent years, we have established a biobank, the Rheumatology BioBank (RheumaBank) headed by the Medicine and Rheumatology unit of the IRCCS Istituto Ortopedico Rizzoli (IOR) in Bologna, Italy for the purpose of collecting, processing, storing, and distributing biological samples and associated data obtained from patients suffering from inflammatory joint diseases. RheumaBank is a research biobank, and its main objective is to promote large-scale, high-quality basic, translational, and clinical research studies that can help elucidate pathogenetic mechanisms and improve personalization of treatment choice in patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA) and other spondyloarthritides (SpA)

Association of Genetic Markers with CSF Oligoclonal Bands in Multiple Sclerosis Patients

Objective:to explore the association between genetic markers and Oligoclonal Bands (OCB) in the Cerebro Spinal Fluid (CSF) of Italian Multiple Sclerosis patients.Methods:We genotyped 1115 Italian patients for HLA-DRB1*15 and HLA-A*02. In a subset of 925 patients we tested association with 52 non-HLA SNPs associated with MS susceptibility and we calculated a weighted Genetic Risk Score. Finally, we performed a Genome Wide Association Study (GWAS) with OCB status on a subset of 562 patients. The best associated SNPs of the Italian GWAS were replicated in silico in Scandinavian and Belgian populations, and meta-analyzed.Results:HLA-DRB1*15 is associated with OCB+: p = 0.03, Odds Ratio (OR) = 1.6, 95% Confidence Limits (CL) = 1.1-2.4. None of the 52 non-HLA MS susceptibility loci was associated with OCB, except one SNP (rs2546890) near IL12B gene (OR: 1.45; 1.09-1.92). The weighted Genetic Risk Score mean was significantly (p = 0.0008) higher in OCB+ (7.668) than in OCB- (7.412) patients. After meta-analysis on the three datasets (Italian, Scandinavian and Belgian) for the best associated signals resulted from the Italian GWAS, the strongest signal was a SNP (rs9320598) on chromosome 6q (p = 9.4×10-7) outside the HLA region (65 Mb).Discussion:genetic factors predispose to the development of OCB