The interaction of amyloid A beta(1-40) with lipid bilayers and ganglioside as studied by P-31 solid-state NMR

Amyloid P-peptide (A beta) is a major component of plaques in Alzheimer's disease, and formation of senile plaques has been suggested to originate fro m regions of neuronal membrane rich in gangliosides. We analyzed the mode of interaction of A beta with lipid bilayers by multinuclear NMR using P-31 nuclei. We found that A beta (1-40) strongly perturbed the bilayer structure of dimyristoylphosphatidylcholine (DMPQ, to form a non-lamellar phase (most likely micellar). The ganglioside GM1 potentiated the effect of A beta (1-40), as viewed from P-31 NMR. The difference of the isotropic peak intensity between DMPC/A beta and DMPC/GM1/A beta suggests a specific interaction between A beta and GM1. We show that in the DMPC/GM1/A beta system there are three lipid phases, namely a lamellar phase, a hexagonal phase and non-oriented lipids. The latter two phases are induced by the presence of the A beta peptide, and facilitated by GM1. 9) 2008 Elsevier Ireland Ltd. All rights reserved

Constraints on the mass of a habitable planet with water of nebular origin

From an astrobiological point of view, special attention has been paid to the probability of habitable planets in extrasolar systems. The purpose of this study is to constrain a possible range of the mass of a terrestrial planet that can get water. We focus on the process of water production through oxidation of the atmospheric hydrogen--the nebular gas having been attracted gravitationally--by oxide available at the planetary surface. For the water production to work well on a planet, a sufficient amount of hydrogen and enough high temperature to melt the planetary surface are needed. We have simulated the structure of the atmosphere that connects with the protoplanetary nebula for wide ranges of heat flux, opacity, and density of the nebular gas. We have found both requirements are fulfilled for an Earth-mass planet for wide ranges of the parameters. We have also found the surface temperature of planets of <= 0.3 Earth masses is lower than the melting temperature of silicate (~ 1500K). On the other hand, a planet of more than several Earth masses becomes a gas giant planet through runaway accretion of the nebular gas.Comment: 25 pages, 8 figures, to appear in the 01 September 2006 issue of Ap

Metallicity of the Fossil Group NGC 1550 Observed with Suzaku

We studied the temperature and metal abundance distributions of the intra-cluster medium (ICM) in a group of galaxies NGC 1550 observed with Suzaku. The NGC 1550 is classified as a fossil group, which have few bright member galaxies except for the central galaxy. Thus, such a type of galaxy is important to investigate how the metals are enriched to the ICM. With the Suzaku XIS instruments, we directly measured not only Si, S, and Fe lines but also O and Mg lines and obtained those abundances to an outer region of ~0.5 r_180 for the first time, and confirmed that the metals in the ICM of such a fossil group are indeed extending to a large radius. We found steeper gradients for Mg, Si, S, and Fe abundances, while O showed almost flat abundance distribution. Abundance ratios of alpha-elements to Fe were similar to those of the other groups and poor clusters. We calculated the number ratio of type II to type Ia supernovae for the ICM enrichment to be 2.9 +- 0.5 within 0.1 r_180, and the value was consistent with those for the other groups and poor clusters observed with Suzaku. We also calculated metal mass-to-light ratios (MLRs) for Fe, O and Mg with B-band and K-band luminosities of the member galaxies of NGC 1550. The derived MLRs were comparable to those of NGC 5044 group in the r<0.1 r_180 region, while those of NGC 1550 are slightly higher than those of NGC 5044 in the outer region.Comment: 11 pages, 7 figures, accepted for publication in PAS

Detection of Excess Hard X-ray Emission from the Group of Galaxies HCG62

From the group of galaxies HCG62, we detected an excess hard X-ray emission in energies above $\sim 4$ keV with \A SCA. The excess emission is spatially extended up to $\sim10'$ from the group center, and somewhat enhanced toward north. Its spectrum can be represented by either a power-law of photon index 0.8-2.7, or a Bremsstrahlung of temperature $>6.3$ keV. In the 2-10 keV range, the observed hard X-ray flux, $(1.0\pm0.3)\times10^{-12}$ erg cm$^{-2}$ s$^{-1}$, implies a luminosity of $(8.0\pm2.0)\times10^{41}$ erg s$^{-1}$ for a Hubble constant of 50 km s$^{-1}$ Mpc$^{-1}$. The emission is thus too luminous to be attributed to X-ray binaries in the memb er galaxies. We discuss possible origin of the hard X-ray emission.Comment: 6 pages, 3 Postscript figures, uses emulateapj.sty. Accepted for publication in the Astrophysical Journal Letter

Automatic Computation of Cross Sections in HEP

For the study of reactions in High Energy Physics (HEP) automatic computation systems have been developed and are widely used nowadays. GRACE is one of such systems and it has achieved much success in analyzing experimental data. Since we deal with the cross section whose value can be given by calculating hundreds of Feynman diagrams, we manage the large scale calculation, so that effective symbolic manipulation, the treat of singularity in the numerical integration are required. The talk will describe the software design of GRACE system and computational techniques in the GRACE.Comment: 6 pages, Latex, ICCP

Late-onset benefit in progressive advanced hepatocellular carcinoma with continued sorafenib therapy: a case report

<p>Abstract</p> <p>Introduction</p> <p>In the past, no effective systemic therapy has existed for patients with advanced hepatocellular carcinoma. Sorafenib, an oral multikinase inhibitor, has recently been shown to improve overall survival in patients with advanced hepatocellular carcinoma in two randomized, double-blinded, placebo-controlled trials. This drug has been approved as the first-line therapy for advanced hepatocellular carcinoma patients. We report an intriguing case of advanced hepatocellular carcinoma in which the patient achieved late- onset partial response by prolonged administration of sorafenib in spite of progressive disease.</p> <p>Case presentation</p> <p>A 54-year-old Japanese man was treated with sorafenib for multiple lung metastases after surgical resection for advanced hepatocellular carcinoma accompanied by vascular invasion of the left branch of the portal vein. Although the effective diagnosis was progressive disease, almost all sites began to reduce or disappear eight months after the diagnosis of progressive disease. A dramatic reduction in alpha-fetoprotein and des-gamma-carboxy prothrombin levels was observed. The patient finally achieved partial response and his status remains unchanged.</p> <p>Conclusions</p> <p>If tolerated, prolonged sorafenib treatment may be beneficial.</p