Lymph node metastasis from colon carcinoma at 11 years after the initial operation managed by lymph node resection and chemoradiation: A case report and a review of the literature

AbstractINTRODUCTIONLymph node metastasis from colorectal cancer after a disease-free interval (DFI) of >5years is extremely rare, and occurs in <0.6% cases.PRESENTATION OF CASEA 60-year-old man underwent low anterior resection for sigmoid colon cancer. The lesion was an adenocarcinoma with no lymph node metastasis of Stage II. At 9years after the colectomy, he was diagnosed with prostate cancer and was treated with radiation and hormonal therapies; at 11years, he exhibited suddenly elevated carcinoembryonic antigen levels. Computed tomography (CT) and positron emission tomography-CT revealed a 2.0-cm para-aortic lymph nodes swelling invading the small intestine. These lymph nodes and the affected segment of the small intestine were resected, and histopathology of the resected specimen confirmed a metastatic tumor. The patient was administered radiation therapy after 22 cycles of 5-fluorouracil, oxaliplatin and leucovorin. He however presented with a residual lesion in the para-aortic lymph node, but currently, he has been symptom free for 4years.DISCUSSIONA review of the literature indicates that the median survival of all previously reported patients is 12months, and that colon cancer with a long DFI might be a slow growing. One of these patients and our patient both had received radiation and/or hormonal therapy for another cancer, which probably impaired their immune systems, thus resulting in metastatic tumors.CONCLUSIONWe report a case of lymph node metastasis after a DFI of >5years and review relevant literature to assess the significance and possible reasons for delayed colorectal cancer metastases

Decreased serum phosphate levels are a useful biomarker to predict occurrence and severity of cytokine release syndrome in chimeric antigen receptor T-cell therapy

サイトカイン放出症候群の発症と重症化を予見する新たな指標 --キメラ抗原受容体T細胞療法における血清リン値が鍵--. 京都大学プレスリリース. 2022-10-19

Indian Monsoonal Variations During the Past 80 Kyr Recorded in NGHP-02 Hole 19B, Western Bay of Bengal: Implications From Chemical and Mineral Properties

金沢大学理工研究域地球社会基盤学系Detailed reconstruction of Indian summer monsoons is necessary to better understand the late Quaternary climate history of the Bay of Bengal and Indian peninsula. We established a chronostratigraphy for a sediment core from Hole 19B in the western Bay of Bengal, extending to approximately 80 kyr BP and examined major and trace element compositions and clay mineral components of the sediments. Higher δ 18 O values, lower TiO 2 contents, and weaker weathering in the sediment source area during marine isotope stages (MIS) 2 and 4 compared to MIS 1, 3, and 5 are explained by increased Indian summer monsoonal precipitation and river discharge around the western Bay of Bengal. Clay mineral and chemical components indicate a felsic sediment source, suggesting the Precambrian gneissic complex of the eastern Indian peninsula as the dominant sediment source at this site since 80 kyr. Trace element ratios (Cr/Th, Th/Sc, Th/Co, La/Cr, and Eu/Eu*) indicate increased sediment contributions from mafic rocks during MIS 2 and 4. We interpret these results as reflecting the changing influences of the eastern and western branches of the Indian summer monsoon and a greater decrease in rainfall in the eastern and northeastern parts of the Indian peninsula than in the western part during MIS 2 and 4. © 2018. American Geophysical Union. All Rights Reserved

Effects of Laser Irradiation and Mechanical Stress on Odontogenic Cells and Tooth Regeneration

Made available in DSpace on 2011-08-22T01:54:47Z (GMT). No. of bitstreams: 2 dent_503.pdf: 857159 bytes, checksum: dd9b7ce952109d40363e9878738b88d0 (MD5) license.txt: 3736 bytes, checksum: 614d80e49a5a996df2598816a3d20516 (MD5) Previous issue date: 2011-03-24歯の欠損に対する根本的治療は喪失してしまった歯を再生することである。しかし、歯の器官としての再生を医療に応用するためには、萌出機序の解明、大きさ・形態の制御、再生期間の短縮などの課題が残されており、完全に達成されていない。従って、現時点では欠損補綴治療として天然歯を支台としたブリッジや天然歯に維持を求めるパーシャルデンチャー、さらにはインプラント補綴が行われている。一方、外傷や先天的・後天的な歯の実質欠損は、金属、陶材、レジンといった人工材料でできた修復物により修復・置換されている。しかし、これらの人工材料には、天然歯の組織に比較し、生体親和性・審美性・機能性といった点において様々な課題が残されているのも事実である。本研究において、再生医療を歯科補綴臨床へ応用する一歩として、細胞組織工学的手法を用いた歯の構成組織、特にエナメル質の再生と歯科補綴装置への応用を目的として研究を行った

Web-Based Telepresence System Using Omni-directional Video Streams

PCM 2004 : Pacific Rim Conference on Multimedia , Nov 30-Dec 3, 2004 , Tokyo, JapanRecently, the telepresence which allows us to experience a remote site through a virtualized real world has been investigated. We have already proposed telepresence systems using omni-directional images which enable the user to look around a virtualized dynamic real scene. The system gives the feeling of high presence to the user. However, conventional systems are not networked but are implemented as stand-alone systems that use immersive displays. In this paper we propose a networked telepresence system which enables the user to see a virtualized real world easily in network environments. This paper describes the system implementation using real-time and stored omni-directional video streams as well as its experiments