Design Of Metal Architectures: Synthesis And Study Of Their Photophysical And Biomolecular Recognition Properties

Design and study of molecular receptors capable of mimicking natural processes has found applications in basic research as well as in the development of potentially useful technologies. Of the various receptors reported, the cyclophanes are known to encapsulate guest molecules in their cavity utilizing various non–covalent interactions resulting in significant changes in their optical properties. This unique property of the cyclophanes has been widely exploited for the development of selective and sensitive probes for a variety of guest molecules including complex biomolecules. Further, the incorporation of metal centres into these systems added new possibilities for designing receptors such as the metallocyclophanes and transition metal complexes, which can target a large variety of Lewis basic functional groups that act as selective synthetic receptors. The ligands that form complexes with the metal ions, and are capable of further binding to Lewis-basic substrates through open coordination sites present in various biomolecules are particularly important as biomolecular receptors. In this context, we synthesized a few anthracene and acridine based metal complexes and novel metallocyclophanes and have investigated their photophysical and biomolecular recognition properties.Cochin University of Science and TechnologyPhotosciences and Photonics Chemical Sciences and Technology Division CSIR-National Institute for Interdisciplinary Science and Technology (CSIR-NIIST), Trivandru

OPTIMIZATION OF RUNNER DESIGN IN HIGH PRESSURE DIE CASTING (HPDC) DIE

 In order to produce high quality parts with high pressure die casting, computer aided simulation has been used to optimize mold designs. Finite difference (differential), finite volume and finite element methods have been used in the filling process simulation and significant progress has been made for general problems. Further work on mold design optimizations is still desired to address specific issues. In die casting, the die often has more than one cavity with multiple cavities producing the same or different parts. Multiple cavities require the application of branch runners connecting to a main runner. The design of the runner system has always been a topic for die casting, since it is important for the designer to ensure that multiple cavities start filling at the same time and have the same fill time. A key factor in the design is to adjust the cross section area of each branch runner according to the cavities’ volumes; however, this may not be enough to fill the cavities simultaneously. The angle between the branch runner and the main runner has been observed to have effects on the filling pressure, filling time and residual stresses, but the observations were limited to very simple lab level die design rather than practical castings

A supramolecular Cu(II) metallocyclophane probe for guanosine 5'-monophosphate

We demonstrate Cu<SUP>2+</SUP> ion induced formation of a novel water soluble metallocyclophane [1.CuCl<SUB>2</SUB>]<SUB>2</SUB>, which uniquely recognizes guanosine 5'-monophosphate through changes in emission intensity utilizing synergistic effects of electrostatic, coordinative and p-stacking interactions inside the cavity

Functional cyclophanes: promising hosts for optical biomolecular recognition

Cyclophanes possess a defined cavity size and are efficient in encapsulating and stabilising guest molecules inside the cavity through various non-covalent interactions. This unique property of the cyclophanes has been widely exploited for the development of selective probes for a variety of guest molecules. The present tutorial review highlights the use of various interesting functionalised cyclophane architectures for the sensitive and selective optical recognition of important biomolecules