832 research outputs found
Rubber Impact on 3D Textile Composites
A low velocity impact study of aircraft tire rubber on 3D textile-reinforced composite plates was performed experimentally and numerically. In contrast to regular unidirectional composite laminates, no delaminations occur in such a 3D textile composite. Yarn decohesions, matrix cracks and yarn ruptures have been identified as the major damage mechanisms under impact load. An increase in the number of 3D warp yarns is proposed to improve the impact damage resistance. The characteristic of a rubber impact is the high amount of elastic energy stored in the impactor during impact, which was more than 90% of the initial kinetic energy. This large geometrical deformation of the rubber during impact leads to a less localised loading of the target structure and poses great challenges for the numerical modelling. A hyperelastic Mooney-Rivlin constitutive law was used in Abaqus/Explicit based on a step-by-step validation with static rubber compression tests and low velocity impact tests on aluminium plates. Simulation models of the textile weave were developed on the meso- and macro-scale. The final correlation between impact simulation results on 3D textile-reinforced composite plates and impact test data was promising, highlighting the potential of such numerical simulation tools
Observation of Spontaneous Brillouin Cooling
While radiation-pressure cooling is well known, the Brillouin scattering of
light from sound is considered an acousto-optical amplification-only process.
It was suggested that cooling could be possible in multi-resonance Brillouin
systems when phonons experience lower damping than light. However, this regime
was not accessible in traditional Brillouin systems since backscattering
enforces high acoustical frequencies associated with high mechanical damping.
Recently, forward Brillouin scattering in microcavities has allowed access to
low-frequency acoustical modes where mechanical dissipation is lower than
optical dissipation, in accordance with the requirements for cooling. Here we
experimentally demonstrate cooling via such a forward Brillouin process in a
microresonator. We show two regimes of operation for the Brillouin process:
acoustical amplification as is traditional, but also for the first time, a
Brillouin cooling regime. Cooling is mediated by an optical pump, and scattered
light, that beat and electrostrictively attenuate the Brownian motion of the
mechanical mode.Comment: Supplementary material include
A quantum spin transducer based on nano electro-mechancial resonator arrays
Implementation of quantum information processing faces the contradicting
requirements of combining excellent isolation to avoid decoherence with the
ability to control coherent interactions in a many-body quantum system. For
example, spin degrees of freedom of electrons and nuclei provide a good quantum
memory due to their weak magnetic interactions with the environment. However,
for the same reason it is difficult to achieve controlled entanglement of spins
over distances larger than tens of nanometers. Here we propose a universal
realization of a quantum data bus for electronic spin qubits where spins are
coupled to the motion of magnetized mechanical resonators via magnetic field
gradients. Provided that the mechanical system is charged, the magnetic moments
associated with spin qubits can be effectively amplified to enable a coherent
spin-spin coupling over long distances via Coulomb forces. Our approach is
applicable to a wide class of electronic spin qubits which can be localized
near the magnetized tips and can be used for the implementation of hybrid
quantum computing architectures
Resolved Sideband Cooling of a Micromechanical Oscillator
Micro- and nanoscale opto-mechanical systems provide radiation pressure
coupling of optical and mechanical degree of freedom and are actively pursued
for their ability to explore quantum mechanical phenomena of macroscopic
objects. Many of these investigations require preparation of the mechanical
system in or close to its quantum ground state. Remarkable progress in ground
state cooling has been achieved for trapped ions and atoms confined in optical
lattices. Imperative to this progress has been the technique of resolved
sideband cooling, which allows overcoming the inherent temperature limit of
Doppler cooling and necessitates a harmonic trapping frequency which exceeds
the atomic species' transition rate. The recent advent of cavity back-action
cooling of mechanical oscillators by radiation pressure has followed a similar
path with Doppler-type cooling being demonstrated, but lacking inherently the
ability to attain ground state cooling as recently predicted. Here we
demonstrate for the first time resolved sideband cooling of a mechanical
oscillator. By pumping the first lower sideband of an optical microcavity,
whose decay rate is more than twenty times smaller than the eigen-frequency of
the associated mechanical oscillator, cooling rates above 1.5 MHz are attained.
Direct spectroscopy of the motional sidebands reveals 40-fold suppression of
motional increasing processes, which could enable reaching phonon occupancies
well below unity (<0.03). Elemental demonstration of resolved sideband cooling
as reported here should find widespread use in opto-mechanical cooling
experiments. Apart from ground state cooling, this regime allows realization of
motion measurement with an accuracy exceeding the standard quantum limit.Comment: 13 pages, 5 figure
Light hadron, Charmonium(-like) and Bottomonium(-like) states
Hadron physics represents the study of strongly interacting matter in all its
manifestations and the understanding of its properties and interactions. The
interest on this field has been revitalized by the discovery of new light
hadrons, charmonium- and bottomonium-like states. I review the most recent
experimental results from different experiments.Comment: Presented at Lepton-Photon 2011, Mumbai, India; 21 pages, 18 figures;
add more references; some correctio
Tunable bipolar optical interactions between guided lightwaves
The optical binding forces between guided lightwaves in dielectric waveguides
can be either repulsive or attractive. So far only attractive force has been
observed. Here we experimentally demonstrate a bipolar optical force between
coupled nanomechanical waveguides. Both attractive and repulsive optical forces
are obtained. The sign of the force can be switched reversibly by tuning the
relative phase of the interacting lightwaves. This tunable, bipolar interaction
forms the foundation for the operation of a new class of light force devices
and circuits.Comment: 4 figure
Demonstration of an ultracold micro-optomechanical oscillator in a cryogenic cavity
Preparing and manipulating quantum states of mechanical resonators is a
highly interdisciplinary undertaking that now receives enormous interest for
its far-reaching potential in fundamental and applied science. Up to now, only
nanoscale mechanical devices achieved operation close to the quantum regime. We
report a new micro-optomechanical resonator that is laser cooled to a level of
30 thermal quanta. This is equivalent to the best nanomechanical devices,
however, with a mass more than four orders of magnitude larger (43 ng versus 1
pg) and at more than two orders of magnitude higher environment temperature (5
K versus 30 mK). Despite the large laser-added cooling factor of 4,000 and the
cryogenic environment, our cooling performance is not limited by residual
absorption effects. These results pave the way for the preparation of 100-um
scale objects in the quantum regime. Possible applications range from
quantum-limited optomechanical sensing devices to macroscopic tests of quantum
physics.Comment: Published versio
Back-action Evading Measurements of Nanomechanical Motion
When performing continuous measurements of position with sensitivity
approaching quantum mechanical limits, one must confront the fundamental
effects of detector back-action. Back-action forces are responsible for the
ultimate limit on continuous position detection, can also be harnessed to cool
the observed structure, and are expected to generate quantum entanglement.
Back-action can also be evaded, allowing measurements with sensitivities that
exceed the standard quantum limit, and potentially allowing for the generation
of quantum squeezed states. We realize a device based on the parametric
coupling between an ultra-low dissipation nanomechanical resonator and a
microwave resonator. Here we demonstrate back-action evading (BAE) detection of
a single quadrature of motion with sensitivity 4 times the quantum zero-point
motion, back-action cooling of the mechanical resonator to n = 12 quanta, and a
parametric mechanical pre-amplification effect which is harnessed to achieve
position resolution a factor 1.3 times quantum zero-point motion.Comment: 19 pages (double-spaced) including 4 figures and reference
Real world study of sacituzumab govitecan in metastatic triple-negative breast cancer in the United Kingdom
\ua9 The Author(s) 2024.Background: Treatment options for pre-treated patients with metastatic triple-negative breast cancer (mTNBC) remain limited. This is the first study to assess the real-world safety and efficacy of sacituzumab govitecan (SG) in the UK. Methods: Data was retrospectively collected from 16 tertiary UK cancer centres. Pts had a diagnosis of mTNBC, received at least two prior lines of treatment (with at least one being in the metastatic setting) and received at least one dose of SG. Results: 132 pts were included. Median age was 56 years (28–91). All patients were ECOG performance status (PS) 0-3 (PS0; 39, PS1; 76, PS2; 16, PS3;1). 75% (99/132) of pts had visceral metastases including 18% (24/132) of pts with CNS disease. Median PFS (mPFS) was 5.2 months (95% CI 4.5–6.6) with a median OS (mOS) of 8.7 months (95% CI 6.8-NA). The most common adverse events (AEs) were fatigue (all grade; 82%, G3/4; 14%), neutropenia (all grade; 55%, G3/4; 29%), diarrhoea (all grade; 58%, G3/4, 15%), and nausea (all grade; 38%, G3/4; 3%). SG dose reduction was required in 54% of pts. Conclusion: This study supports significant anti-tumour activity in heavily pre-treated pts with mTNBC. Toxicity data aligns with clinical trial experience
Semi-automatic identification of punching areas for tissue microarray building: the tubular breast cancer pilot study
Background: Tissue MicroArray technology aims to perform immunohistochemical staining on hundreds of different tissue samples simultaneously. It allows faster analysis, considerably reducing costs incurred in staining. A time consuming phase of the methodology is the selection of tissue areas within paraffin blocks: no utilities have been developed for the identification of areas to be punched from the donor block and assembled in the recipient block.Results: The presented work supports, in the specific case of a primary subtype of breast cancer (tubular breast cancer), the semi-automatic discrimination and localization between normal and pathological regions within the tissues. The diagnosis is performed by analysing specific morphological features of the sample such as the absence of a double layer of cells around the lumen and the decay of a regular glands-and-lobules structure. These features are analysed using an algorithm which performs the extraction of morphological parameters from images and compares them to experimentally validated threshold values. Results are satisfactory since in most of the cases the automatic diagnosis matches the response of the pathologists. In particular, on a total of 1296 sub-images showing normal and pathological areas of breast specimens, algorithm accuracy, sensitivity and specificity are respectively 89%, 84% and 94%.Conclusions: The proposed work is a first attempt to demonstrate that automation in the Tissue MicroArray field is feasible and it can represent an important tool for scientists to cope with this high-throughput technique
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