Ion Exchange Resin Impregnated Paper Chromatography of Some Typical Chlorinated Pesticides

The purpose of this project was to examine the effect the ionic immobile phase of various ion exchange resin-impregnated papers has on the separability of some typical chlorinated pesticides; the ultimate goal was devising an ion exchange resin-impregnated paper chromatographic system which would provide better chlorinated pesticide resolution than conventional paper chromatographic methods

Three‐dimensional study of Mars upper thermosphere/ionosphere and hot oxygen corona: 1. General description and results at equinox for solar low conditions

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/94871/1/jgre2685.pd

Solar wind interaction with Mars upper atmosphere: Results from the one‐way coupling between the multifluid MHD model and the MTGCM model

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/106987/1/grl51608.pd

Commercial Applications of Spaceport Cryogenic Technologies: Technologies, Facilities, Capabilities, and Expertise

No abstract availabl

Solar wind interaction with the Martian upper atmosphere: Crustal field orientation, solar cycle, and seasonal variations

A comprehensive study of the solar wind interaction with the Martian upper atmosphere is presented. Three global models: the 3‐D Mars multifluid Block Adaptive Tree Solar‐wind Roe Upwind Scheme MHD code (MF‐MHD), the 3‐D Mars Global Ionosphere Thermosphere Model (M‐GITM), and the Mars exosphere Monte Carlo model Adaptive Mesh Particle Simulator (M‐AMPS) were used in this study. These models are one‐way coupled; i.e., the MF‐MHD model uses the 3‐D neutral inputs from M‐GITM and the 3‐D hot oxygen corona distribution from M‐AMPS. By adopting this one‐way coupling approach, the Martian upper atmosphere ion escape rates are investigated in detail with the combined variations of crustal field orientation, solar cycle, and Martian seasonal conditions. The calculated ion escape rates are compared with Mars Express observational data and show reasonable agreement. The variations in solar cycles and seasons can affect the ion loss by a factor of ∼3.3 and ∼1.3, respectively. The crustal magnetic field has a shielding effect to protect Mars from solar wind interaction, and this effect is the strongest for perihelion conditions, with the crustal field facing the Sun. Furthermore, the fraction of cold escaping heavy ionospheric molecular ions [(2+ and/or 2+)/Total] are inversely proportional to the fraction of the escaping (ionospheric and corona) atomic ion [O+/Total], whereas 2+ and 2+ ion escape fractions show a positive linear correlation since both ion species are ionospheric ions that follow the same escaping path.Key PointsStudy crustal field, solar cycle, and seasons on Mars' upper atmosphere ion escapeTo understand the long‐term evolution of Mars atmosphere over its historyTo support MAVEN spacecraft mission data analysis (2014–2016)Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/115901/1/jgra52040.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/115901/2/jgra52040_am.pd

Ibuprofen slows migration and inhibits bowel colonization by enteric nervous system precursors in zebrafish, chick and mouse

AbstractHirschsprung Disease (HSCR) is a potentially deadly birth defect characterized by the absence of the enteric nervous system (ENS) in distal bowel. Although HSCR has clear genetic causes, no HSCR-associated mutation is 100% penetrant, suggesting gene–gene and gene-environment interactions determine HSCR occurrence. To test the hypothesis that certain medicines might alter HSCR risk we treated zebrafish with medications commonly used during early human pregnancy and discovered that ibuprofen caused HSCR-like absence of enteric neurons in distal bowel. Using fetal CF-1 mouse gut slice cultures, we found that ibuprofen treated enteric neural crest-derived cells (ENCDC) had reduced migration, fewer lamellipodia and lower levels of active RAC1/CDC42. Additionally, inhibiting ROCK, a RHOA effector and known RAC1 antagonist, reversed ibuprofen effects on migrating mouse ENCDC in culture. Ibuprofen also inhibited colonization of Ret+/− mouse bowel by ENCDC in vivo and dramatically reduced bowel colonization by chick ENCDC in culture. Interestingly, ibuprofen did not affect ENCDC migration until after at least three hours of exposure. Furthermore, mice deficient in Ptgs1 (COX 1) and Ptgs2 (COX 2) had normal bowel colonization by ENCDC and normal ENCDC migration in vitro suggesting COX-independent effects. Consistent with selective and strain specific effects on ENCDC, ibuprofen did not affect migration of gut mesenchymal cells, NIH3T3, or WT C57BL/6 ENCDC, and did not affect dorsal root ganglion cell precursor migration in zebrafish. Thus, ibuprofen inhibits ENCDC migration in vitro and bowel colonization by ENCDC in vivo in zebrafish, mouse and chick, but there are cell type and strain specific responses. These data raise concern that ibuprofen may increase Hirschsprung disease risk in some genetically susceptible children

Venus mesosphere and thermosphere : II. Global circulation, temperature, and density variations

Recent Pioneer Venus observations have prompted a return to comprehensive hydrodynamical modeling of the thermosphere of Venus. Our approach has been to reexamine the circulation and structure of the thermosphere using the framework of the [Dickinson and Ridley, 1977], symmetric two-dimensional model. Sensitivity tests were conducted to see how large-scale winds, eddy diffusion and conduction, and strong 15-[mu]m cooling affect day-night contrasts of densities and temperatures. The calculated densities and temperatures are compared to symmetric empirical model fields constructed from the Pioneer Venus data base. We find that the observed day-to-night variation of composition and temperatures can be derived largely by a wave-drag parameterization that gives a circulation system weaker than predicted prior to Pioneer Venus. The calculated mesospheric winds are consistent with Earth-based observations near 115 km. Our studies also suggest that eddy diffusion is only a minor contributor to the maintenance of observed day and nightside densities, and that eddy coefficients are smaller than values used by previous one-dimensional composition models. The mixing that occurs in the Venus thermosphere results from small-scale and large-scale motions. Strong CO2 15-[mu]m cooling buffers solar perturbation such that the response by the general circulation to solar cycle variation is relatively weak.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/25994/1/0000060.pd

Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease

Evolocumab is a monoclonal antibody that inhibits proprotein convertase subtilisin-kexin type 9 (PCSK9) and lowers low-density lipoprotein (LDL) cholesterol levels by approximately 60%. Whether it prevents cardiovascular events is uncertain.We conducted a randomized, double-blind, placebo-controlled trial involving 27,564 patients with atherosclerotic cardiovascular disease and LDL cholesterol levels of 70 mg per deciliter (1.8 mmol per liter) or higher who were receiving statin therapy. Patients were randomly assigned to receive evolocumab (either 140 mg every 2 weeks or 420 mg monthly) or matching placebo as subcutaneous injections. The primary efficacy end point was the composite of cardiovascular death, myocardial infarction, stroke, hospitalization for unstable angina, or coronary revascularization. The key secondary efficacy end point was the composite of cardiovascular death, myocardial infarction, or stroke. The median duration of follow-up was 2.2 years.At 48 weeks, the least-squares mean percentage reduction in LDL cholesterol levels with evolocumab, as compared with placebo, was 59%, from a median baseline value of 92 mg per deciliter (2.4 mmol per liter) to 30 mg per deciliter (0.78 mmol per liter) (P<0.001). Relative to placebo, evolocumab treatment significantly reduced the risk of the primary end point (1344 patients [9.8%] vs. 1563 patients [11.3%]; hazard ratio, 0.85; 95% confidence interval [CI], 0.79 to 0.92; P<0.001) and the key secondary end point (816 [5.9%] vs. 1013 [7.4%]; hazard ratio, 0.80; 95% CI, 0.73 to 0.88; P<0.001). The results were consistent across key subgroups, including the subgroup of patients in the lowest quartile for baseline LDL cholesterol levels (median, 74 mg per deciliter [1.9 mmol per liter]). There was no significant difference between the study groups with regard to adverse events (including new-onset diabetes and neurocognitive events), with the exception of injection-site reactions, which were more common with evolocumab (2.1% vs. 1.6%).In our trial, inhibition of PCSK9 with evolocumab on a background of statin therapy lowered LDL cholesterol levels to a median of 30 mg per deciliter (0.78 mmol per liter) and reduced the risk of cardiovascular events. These findings show that patients with atherosclerotic cardiovascular disease benefit from lowering of LDL cholesterol levels below current targets. (Funded by Amgen; FOURIER ClinicalTrials.gov number, NCT01764633 .)

Delayed Imitation of Lipsmacking Gestures by Infant Rhesus Macaques (Macaca mulatta)

Human infants are capable of accurately matching facial gestures of an experimenter within a few hours after birth, a phenomenon called neonatal imitation. Recent studies have suggested that rather than being a simple reflexive-like behavior, infants exert active control over imitative responses and ‘provoke’ previously imitated gestures even after a delay of up to 24 h. Delayed imitation is regarded as the hallmark of a sophisticated capacity to control and flexibly engage in affective communication and has been described as an indicator of innate protoconversational readiness. However, we are not the only primates to exhibit neonatal imitation, and delayed imitation abilities may not be uniquely human. Here we report that 1-week-old infant rhesus macaques (Macaca mulatta) who show immediate imitation of a lipsmacking gesture also show delayed imitation of lipsmacking, facilitated by a tendency to refrain from lipsmacking toward a still face during baseline measurements. Individual differences in delayed imitation suggest that differentially matured cortical mechanisms may be involved, allowing some newborns macaques to actively participate in communicative exchanges from birth. Macaque infants are endowed with basic social competencies of intersubjective communication that indicate cognitive and emotional commonality between humans and macaques, which may have evolved to nurture an affective mother-infant relationship in primates

Models of Venus neutral upper atmosphere: Structure and composition

Models of the Venus neutral upper atmosphere, based on both in-situ and remote sensing measurements, are provided for the height interval from 100 to 3,500 km. The general approach in model formulation was to divide the atmosphere into three regions: 100 to 150 km, 150 to 250 km, and 250 to 3,500 km. Boundary conditions at 150 km are consistent with both drag and mass spectrometer measurements. A paramount consideration was to keep the models simple enough to be used conveniently. Available observations are reviewed. Tables are provided for density, temperature, composition (CO2, O, CO, He, N, N2, and H), derived quantities, and day-to-day variability as a function of solar zenith angle on the day- and nightsides.Estimates are made of other species, including O2 and D. Other tables provide corrections for solar activity effects on temperature, composition, and density. For the exosphere, information is provided on the vertical distribution of normal thermal components (H, O, C, and He) as well as the hot components (H, N, C, O) on the day- and nightsides.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/25840/1/0000403.pd