Drainage Morphology Approach For Water Resources Development of Sub Watershed in Krishna Basin

The morphometric analysis of study area has been carried out using Arc GIS software. The study area covers 3035 sq.km. The drainage network was delineated using SOI topographical map of no. 47 K – 5, 6, 7, 8, 10, 11, 12, 47 L - 9 on the scale 1:50,000. Morphological characterized of the drainage line as appear in shape ,size, number, order, length, Dd, Sf, Rb, Fs, T, Rc are derived to trace its usefulness for surface development . The present study involves Geographic Information System (GIS) analysis technique to evaluate and compare linear relief and aerial morphometry of Yerala watershed of Krishna River. Yerala watershed is basically 7th order drainage and is mainly dendritic to sub dendritic. Drainage density and texture of the drainage basin is 6.89 km/km2, 18.60 respectively. The drainage frequency of Yerala watersheds is 1.96 where as the bifurcation ratio ranges from 2 to 11. Hence from the study it can be conclude that GIS technique proves to be competent tool in morphometric analysis

Role of Higher Multipole Excitations in the Electromagnetic Dissociation of One Neutron Halo Nuclei

We investigate the role of higher multipole excitations in the electromagnetic dissociation of one-neutron halo nuclei within two different theoretical models -- a finite range distorted wave Born approximation and another in a more analytical method with a finite range potential. We also show, within a simple picture, how the presence of a weakly bound state affects the breakup cross section.Comment: 8 pages, 9 figure

Magnetic Properties of Ternary Gallides of type RNi4Ga (R = Rare earths)

The magnetic properties of RNi4Ga (R = La, Pr, Nd, Sm, Gd, Tb, Dy, Ho, Er, Tm and Lu) compounds have been investigated. These compounds form in a hexagonal CaCu5 type structure with a space group P6/mmm. Compounds with the magnetic rare earths, R = Nd, Sm, Gd, Tb, Dy, Ho, Er and Tm, undergo a ferromagnetic transition at 5 K, 17 K, 20 K, 19 K, 12 K, 3.5 K, 8 K and 6.5 K, respectively. The transition temperatures are smaller compared to their respective parent compounds RNi5. PrNi4Ga is paramagnetic down to 2 K. LaNi4Ga and LuNi4Ga are Pauli paramagnets. All the compounds show thermomagnetic irreversibility in the magnetically ordered state except GdNi4Ga.Comment: 14 Pages 6 Figures 1 Tabl

Antigenic competition among different ‘O’ antigens of <i style="">Salmonella enterica</i> subspecies <i style="">enterica</i> serovars during hyperimmunization in pony mares

1022-1025The present study on antigenic competition among somatic ‘O’ antigens of different Salmonella groups (A, B, C1, C2, D and E1) in mares revealed that the immune response to most of the antigens was not (A, B, C2) or little (C1, D) affected by antigenic competition. However, E1 group antigen, which induced high antibody titres (Avg. 12967.3) when given alone, produced almost 3.5 log2 lower antibody titres on giving with other antigens, indicating the antigenic competition among some Salmonella group antigens. The antigenic competition varied for different antigens even of the similar chemical nature. Therefore, antigens belonging to different somatic groups should not be given together for the purpose of raising polyvalent serum or for immunization using multivalent Salmonella vaccines prepared from strains of different ‘O’ groups revealing antigenic competition

A randomised controlled trial to assess the impact of audiotaped consultations on the quality of informed consent in cardiac surgery

&lt;b&gt;Context&lt;/b&gt;: Informed Consent has become a contentious issue over the last few decades. It has been discussed and debated in all specialties of medicine. &lt;b&gt;Objective&lt;/b&gt;: We have used a previously published and validated questionnaire, which was designed to measure patients’ level of knowledge within the domains described in the General Medical Council’s informed consent guidelines, to evaluate the impact of audiotaping outpatient consultations on informed consent in cardiac surgery. &lt;b&gt;Design&lt;/b&gt;: Randomised Controlled Trial &lt;b&gt;Setting&lt;/b&gt;: Tertiary health care centre in Scotland &lt;b&gt;Participants&lt;/b&gt;: Patients attending outpatient clinic prior to first time coronary artery bypass grafting were recruited. We made audiotape recordings of outpatient consultations conducted by a single consultant surgeon with 84 patients. &lt;b&gt;Intervention&lt;/b&gt;: The participants were randomly allocated to three trial arms. The control group (Group A; n = 29) received no tape. The 'generic' group (Group B; n = 25) received a copy of a tape which contained general information about coronary artery surgery which we scripted to include information covering each of the domains described by the General Medical Council. The 'consultation' group (Group C; n = 30) received a tape of their consultation interview. Patients were then interviewed on admission to hospital, shortly after giving consent. As well as the knowledge questionnaire, the Multidimensional Health Locus of Control (MHLC) and Hospital Anxiety and Depression Scale (HADS) were administered. &lt;b&gt;Main outcome measures&lt;/b&gt;: Impact of audiotape in improving the informed consent process, as measured by a knowledge questionnaire, in cardiac surgery. Its impact on health locus of control and anxiety and depression was also assessed. &lt;b&gt;Results&lt;/b&gt;: The mean knowledge score of patients who received a recording of their consultation was almost two-and-a-half times greater than that of the controls (p&lt;0.001). Patients who received a consultation recording reported a significantly greater sense of control over their own health (p&lt;0.001) and were overall less anxious and depressed. &lt;b&gt;Conclusion&lt;/b&gt;: Providing an audiotape of the consultation before cardiac surgery appears to improve patients’ knowledge whilst increasing their perceptions of control of their health status and reducing levels of anxiety and depression

In vitro and in vivo activities of the nitroimidazole CGI 17341 against Mycobacterium tuberculosis

CGI 17341 (2-ethyl-5-nitro-2,3-dihydro[2-1b]imidazo-oxazole) is a novel orally active representative of the 5-nitroimidazole series of antimicrobial agents. At concentrations ranging from 0.1 to 0.3 micrograms/ml, CGI 17341 inhibited the drug-susceptible and multi-drug-resistant strains of Mycobacterium tuberculosis. CGI 17341 had no cross-resistance with isoniazid, rifampin, streptomycin, or ethambutol. While the in vitro activity of CGI 17341 against M. tuberculosis was comparable to those of isoniazid and rifampin, it was superior to those of streptomycin, ciprofloxacin or norfloxacin, and oxazolidinone DuP 721. The MIC of CGI 17341 was not affected when the pH of the medium was decreased from 6.8 to 5.6, while four- to sixfold increases in the MICs of ciprofloxacin and isoniazid were observed. In mice infected with M. tuberculosis, the 50% effective dose for CGI 17341 was 7.7 mg/kg of body weight (95% confidence limits, 3.5 and 10.27) when administered on days 11 and 12 postinfection. CGI 17341 gave a dose-dependent (r = 0.995) and significant increase in the survival time. Our data indicate that the 5-nitroimidazole CGI 17341 is a promising and novel antituberculosis compound with potent in vitro and in vivo activities. Further investigations on this compound are warranted

Positron Emission Tomography—Computer Tomography Scan Used as a Monitoring Tool Following Cellular Therapy in Cerebral Palsy and Mental Retardation—A Case Report

Cerebral palsy (CP) is one of the non-progressive neurological diseases caused by damage to the brain tissue at birth, which leads to physical, cognitive and perceptive symptoms. Even after lifelong medical and therapeutic management there are residual deficits which affect the quality of life of the patients and their families. We examined a maximally rehabilitated, 20 year old male suffering from CP and Mental Retardation (MR). He had diplegic gait and Intelligence Quotient (IQ) score of 44 with affected fine motor activities, balance, speech and higher functions. Positron Emission Tomography—Computer Tomography (PET-CT) scan identified frontal, temporal, parietal, occipital, left cerebellar lobes, amygdala, hippocampus, and parahippocampus as the affected areas. He was treated with cellular therapy of Autologous Bone Marrow Derived Mono-Nuclear Cells (MNCs) transplantation followed by multidisciplinary rehabilitation. Six months following therapy, PET-CT scan showed significant increase in metabolic activity in all four lobes, mesial temporal structures and left cerebellar hemisphere, also supported by clinical improvement in IQ, social behavior, speech, balance and daily functioning. These findings provide preliminary evidence to support the efficacy of cellular therapy for the treatment of CP with MR. PET-CT scan can also be viewed as an impressive tool to monitor the effects of cellular therapy

Detailed analysis of the clinical effects of cell therapy for thoracolumbar spinal cord injury: an original study

Alok Sharma,1 Nandini Gokulchandran,1 Hemangi Sane,2 Prerna Badhe,1 Pooja Kulkarni,2 Mamta Lohia,3 Anjana Nagrajan,3 Nancy Thomas3 1Department of Medical Services and Clinical Research, 2Department of Research and Development, 3Department of Neurorehabilitation, NeuroGen Brain and Spine Institute, Surana Sethia Hospital and Research Centre, Chembur, Mumbai, India Background: Cell therapy is amongst the most promising treatment strategies in spinal cord injury (SCI) because it focuses on repair. There are many published animal studies and a few human trials showing remarkable results with various cell types. The level of SCI determines whether paraplegia or quadriplegia is present, and greatly influences recovery. The purpose of this study was to determine the significance of the clinical effects and long-term safety of intrathecal administration of autologous bone marrow-derived mononuclear cells, along with changes in functional independence and quality of life in patients with thoracolumbar SCI. Methods: We undertook a retrospective analysis of a clinical study in which a nonrandomized sample of 110 patients with thoracolumbar SCI underwent autologous bone marrow-derived mononuclear cell transplantation intrathecally and subsequent neurorehabilitation, with a mean follow-up of 2 years &plusmn; 1 month. Changes on any parameters were recorded at follow-up. The data were analyzed using the Wilcoxon&#39;s signed-rank test and McNemar&#39;s test. Functional Independence Measure and American Spinal Injury Association (ASIA) scores were recorded, and a detailed neurological assessment was performed. Results: Overall improvement was seen in 91% of patients, including reduction in spasticity, partial sensory recovery, and improvement in trunk control, postural hypotension, bladder management, mobility, activities of daily living, and functional independence. A significant association of these symptomatic improvements with the cell therapy intervention was established by the statistical analysis. Some patients showed a shift on the ASIA scale and changes in electrophysiological studies or functional magnetic resonance imaging. No major side effects were noted. Conclusion: In patients with thoracolumbar SCI, there were statistically significant beneficial effects, both symptomatic and functional, from intrathecal autologous bone marrow-derived mononuclear cell therapy and rehabilitation. This was a safe and viable therapeutic option with no long-term side effects at 2 years. This analytical study is an early documentation of cell therapy, and can be used as a guide to devise larger more refined clinical trials. Keywords: cell therapy, spinal cord injury, autologous, bone marrow-derived mononuclear cells, intrathecal administratio

Autologous Bone Marrow Mononuclear Cells in Ischemic Cerebrovascular Accident Paves Way for Neurorestoration: A Case Report

In response to acute ischemic stroke, large numbers of bone marrow stem cells mobilize spontaneously in peripheral blood that home onto the site of ischemia activating the penumbra. But with chronicity, the numbers of mobilized cells decrease, reducing the degree and rate of recovery. Cellular therapy has been explored as a new avenue to restore the repair process in the chronic stage. A 67-year-old Indian male with a chronic right middle cerebral artery ischemic stroke had residual left hemiparesis despite standard management. Recovery was slow and partial resulting in dependence to carry out activities of daily living. Our aim was to enhance the speed of recovery process by providing an increased number of stem cells to the site of injury. We administered autologous bone marrow mononuclear cells intrathecally alongwith rehabilitation and regular follow up. The striking fact was that the hand functions, which are the most challenging deficits, showed significant recovery. Functional Independence Measure scores and quality of life improved. This could be attributed to the neural tissue restoration. We hypothesize that cell therapy may be safe, novel and appealing treatment for chronic ischemic stroke. Further controlled trials are indicated to advance the concept of Neurorestoration