Clonal Interference, Multiple Mutations, and Adaptation in Large Asexual Populations

Two important problems affect the ability of asexual populations to accumulate beneficial mutations, and hence to adapt. First, clonal interference causes some beneficial mutations to be outcompeted by more-fit mutations which occur in the same genetic background. Second, multiple mutations occur in some individuals, so even mutations of large effect can be outcompeted unless they occur in a good genetic background which contains other beneficial mutations. In this paper, we use a Monte Carlo simulation to study how these two factors influence the adaptation of asexual populations. We find that the results depend qualitatively on the shape of the distribution of the effects of possible beneficial mutations. When this distribution falls off slower than exponentially, clonal interference alone reasonably describes which mutations dominate the adaptation, although it gives a misleading picture of the evolutionary dynamics. When the distribution falls off faster than exponentially, an analysis based on multiple mutations is more appropriate. Using our simulations, we are able to explore the limits of validity of both of these approaches, and we explore the complex dynamics in the regimes where neither are fully applicable.Comment: 24 pages, 5 figure

Observational and theoretical studies of the evolving structure of baroclinic waves

Dynamical processes involved in comma cloud formation, and passive tracer evolution in a baroclinic wave are discussed. An analytical solution was obtained demonstrating the complex nongeostrophic flow pattern involved in the redistribution of low level constituents in a finite amplitude baroclinic wave, and in the formation of the typical humidity and cloud distributions in such a wave. Observational and theoretical studies of blocking weather patterns in middle latitude flows were studied. The differences in the energy and enstrophy cascades in blocking and nonblocking situations were shown. It was established that pronounced upscale flow of both of these quantities, from intermediate to planetary scales, occurs during blocking episodes. The upscale flux of enstrophy, in particular, suggests that the persistence of blocking periods may be due to reduced dissipation of the large scale circulation and therefore entail some above normal predictability

Studies of heat source driven natural convection

Natural convection energy transport in a horizontal layer of internally heated fluid with a zero heat flux lower boundary, and an isothermal upper boundary, has been studied. Quantitative information on the time-mean temperature distribution and the fluctuating component of temperature about the mean temperature in steady turbulent convection are obtained from a small thermocouple inserted into the layer through the upper bounding plate. Data are also presented on the development of temperature at several vertical positions when the layer is subject to both a sudden increase and to a sudden decrease in power input. For changes of power input from zero to a value corresponding to a Rayleigh number much greater than the critical linear stability theory value, a slight hysteresis in temperature profiles near the upper boundary is observed between the heat-up and cool-down modes

Phasespace Correlations of Antideuterons in Heavy Ion Collisions

In the framework of the relativistic quantum molecular dynamics approach ({\small RQMD}) we investigate antideuteron ($\overline{d}$) observables in Au+Au collisions at 10.7~AGeV. The impact parameter dependence of the formation ratios $\overline{d}/\overline{p}^2$ and ${d}/{p}^2$ is calculated. In central collisions, the antideuteron formation ratio is predicted to be two orders of magnitude lower than the deuteron formation ratio. The $\overline{d}$ yield in central Au+Au collisions is one order of magnitude lower than in Si+Al collisions. In semicentral collisions different configuration space distributions of $\overline{p}$'s and $\overline{d}$'s lead to a large ``squeeze--out'' effect for antideuterons, which is not predicted for the $\overline{p}$'s

Comparing Energy Expenditure During Land and Shallow Water Walking in Overweight and Obese Females

Introduction: The prevalence of overweight and obesity in the United States has reached epidemic levels. Reduction in body weight is of great importance for overweight and obese individuals through the increase in physical activity. One particular mode of physical activity that is currently growing in popularity is shallow water walking, although little research has been done examining the energy cost of this activity in an overweight and obese population. Purpose: To compare the energy expenditure (kcal/min) and rating of perceived exertion (RPE) of a bout shallow water walking at a self-selected pace to a bout of land walking at a matched heart rate response and to a bout of land walking at a self-selected pace in overweight and obese women. Methods: Nineteen participants completed three 10-minute experimental trials including a self-selected pace shallow water walking trial, a matched heart rate response land walking trial, and a self-selected pace land walking trial. Results: Significantly lower energy expenditure (p= 0.046) was observed for shallow water walking (6.46 ± 1.38 kcal/min) compared to the matched heart rate response land walking bout (7.26 ± 1.29 kcal/min), although no significant differences were detected for energy expenditure for shallow water walking and self-selected pace land walking (6.92 ± 1.61 kcal/min). No significant differences were detected for RPE across conditions (p=0.439). Exploratory analyses revealed correlations between measures of body composition (BMI and percent body fat) and the difference in energy expenditure between shallow water walking and matched heart rate response land walking. Conclusions: Findings from the current study suggest that although producing energy expenditure compared to heart rate matched land walking, shallow water walking is a viable alternative that can elicit and increase in energy expenditure performed at a moderate intensity, meeting ACSM criteria. Results of the exploratory analyses revealed an association between measures of body composition and differences in energy expenditure. Although only a limited number of participants of the present study had BMI’s above 35.0 kg/m2 (n=2), findings suggest that water exercise may be an alternative form of exercise and produce higher caloric expenditure at higher ranges of BMI and percent body fat

The Kasteleyn model and a cellular automaton approach to traffic flow

We propose a bridge between the theory of exactly solvable models and the investigation of traffic flow. By choosing the activities in an apropriate way the dimer configurations of the Kasteleyn model on a hexagonal lattice can be interpreted as space-time trajectories of cars. This then allows for a calculation of the flow-density relationship (fundamental diagram). We further introduce a closely-related cellular automaton model. This model can be viewed as a variant of the Nagel-Schreckenberg model in which the cars do not have a velocity memory. It is also exactly solvable and the fundamental diagram is calculated.Comment: Latex, 13 pages including 3 ps-figure

A Comparative Study of the Valence Electronic Excitations of N_2 by Inelastic X-ray and Electron Scattering

Bound state, valence electronic excitation spectra of N_2 are probed by nonresonant inelastic x-ray and electron scattering. Within the usual theoretical treatments, dynamical structure factors derived from the two probes should be identical. However, we find strong disagreements outside the dipole scattering limit, even at high probe energies. This suggests an unexpectedly important contribution from intra-molecular multiple scattering of the probe electron from core electrons or the nucleus. These effects should grow progressively stronger as the atomic number of the target species increases.Comment: Submitted to Physical Review Letters April 27, 2010. 12 pages including 2 figure pages

Laser-actuated holographic storage device

Device permits automatic selection of one out of thousands of pages in holographic memory system by using laser beam. In typical operation for 2 to 3 C temperature interval, using dc power supply with no power regulation, holograms were successfully written and erased over 2- by 2-cm area, using 80-mW argon laser beam

Coulomb and Liquid Dimer Models in Three Dimensions

We study classical hard-core dimer models on three-dimensional lattices using analytical approaches and Monte Carlo simulations. On the bipartite cubic lattice, a local gauge field generalization of the height representation used on the square lattice predicts that the dimers are in a critical Coulomb phase with algebraic, dipolar, correlations, in excellent agreement with our large-scale Monte Carlo simulations. The non-bipartite FCC and Fisher lattices lack such a representation, and we find that these models have both confined and exponentially deconfined but no critical phases. We conjecture that extended critical phases are realized only on bipartite lattices, even in higher dimensions.Comment: 4 pages with corrections and update