555 research outputs found

    Green Tea Catechins for Prostate Cancer Chemoprevention

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    Progress Towards Modeling the Ablation Response of NuSil-Coated PICA

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    The Mars Science Laboratory (MSL) Entry, Descent and Landing Instrumentation (MEDLI) collected in-flight data largely used by the ablation community to verify and validate physics-based models for the response of the Phenolic Impregnated Carbon Ablator (PICA) material [1-4]. MEDLI data were recently used to guide the development of NASAs high-fidelity material response models for PICA, implemented in the Porous material Analysis Toolbox based on OpenFOAM (PATO) software [5-6]. A follow-up instrumentation suite, MEDLI2, is planned for the upcoming Mars 2020 mission [7] after the large scientific impact of MEDLI. Recent analyses performed as part of MEDLI2 development draw the attention to significant effects of a protective coating to the aerothermal response of PICA. NuSil, a silicone-based overcoat sprayed onto the MSL heatshield as contamination control, is currently neglected in PICA ablation models. To mitigate the spread of phenolic dust from PICA, NuSil was applied to the entire MSL heatshield, including the MEDLI plugs. NuSil is a space grade designation of the siloxane copolymer, primarily used to protect against atomic oxygen erosion in the Low Earth Orbit environment. Ground testing of PICA-NuSil (PICA-N) models all exhibited surface temperature jumps of the order of 200 K due to oxide scale formation and subsequent NuSil burn-off. It is therefore critical to include a model for the aerothermal response of the coating in ongoing code development and validation efforts

    Inverse Determination of Aeroheating and Charring Ablator Response

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    The Mars Science Laboratory (MSL) was protected during its Mars atmospheric entry by an instrumented heatshield that used NASA's Phenolic Impregnated Carbon Ablator (PICA). PICA is a lightweight carbon fiber/polymeric resin material that offers excellent performances for protecting probes during planetary entry. The Mars Entry Descent and Landing Instrument (MEDLI) suite on MSL offers unique in-flight validation data for models of atmospheric entry and material response. MEDLI recorded, among others, time-resolved in-depth temperature data of PICA using thermocouple sensors assembled in the MEDLI Integrated Sensor Plugs (MISP). These measurements have been widely used in the literature as a validation benchmark for state-of-the-art ablation codes. The objective of this work is to perform an inverse estimate of the MSL heatshield material properties and aerothermal environment during Mars entry from the MISP flight data

    Preliminary Measurements of the Motion of Arcjet Current Channel Using Inductive Magnetic Probes

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    This paper covers the design and first measurements of non-perturbative, external inductive magnetic diagnostics for arcjet constrictors which can measure the motion of the arc current channel. These measurements of arc motion are motivated by previous simulations using the ARC Heater Simulator (ARCHeS), which predicted unsteady arc motion due to the magnetic kink instability. Measurements of the kink instability are relevant to characterizing motion of the enthalpy profile of the arcjet, the arcjet operational stability, and electrode damage due to associated arc detachment events. These first measurements indicate 4 mm oscillations at 0.5-2 kHz of the current profile

    Significance of DSMC Computed Aerothermal Environments in the Rarefied Regime for Atmospheric Entry Material Response

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    During Mars atmospheric entry, the Mars Science Laboratory (MSL) was protected by a 4.5 meters diameter ablative heatshield assembled in 113 tiles. The heatshield was made of NASA's flagship ablative material, the Phenolic Impregnated Carbon Ablator (PICA). Prior work compared the traditional one-dimensional and three-dimensional material response models at different locations in the heatshield. It was observed that the flow was basically one-dimensional in the nose and flank regions, but three-dimensional flow effects were observed in the outer flank. The objective of this work is to study the effects of the aerothermal environment on the material response. We extend prior work by computing aerothermal environments using the direct simulation Monte Carlo (DSMC) code SPARTA and the CFD code Data Parallel Line Relaxation (DPLR). SPARTA is used to compute environment in the rarefied regime prior to 48.4s of entry where the Knudsen number is such that the Navier-Stokes equations can be inaccurate. Similarly to previous work, the DPLR software is used to compute the hypersonic environment for laminar then turbulent boundary layer assumptions from 48.4 s up to 100 s after Entry Interface (EI) along the MSL 08-TPS-02/01a trajectory. We observe that extending the aerothermal environments to times prior to 48.4 s modifies the thermal response of the heat shield at the surface and in-depth; however the effects on the recession are minimal. Additionally, using the assumption of a turbulent boundary layer versus a laminar one leads to higher surface and in-depth temperatures, larger recession, and a displacement of the peak heating and peak recession location

    Full-Scale MSL Heatshield Material Response Using DSMC and CFD to Compute the Aerothermal Environments

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    During Mars atmospheric entry, the Mars Science Laboratory (MSL) was protected by a 4.5 meters diameter ablative heatshield assembled in 113 tiles [1]. The heatshield was made of NASA's flagship ablative material, the Phenolic Impregnated Carbon Ablator (PICA) [2]. Prior work [3] compared the traditional one-dimensional and three-dimensional material response models at different locations in the heatshield. It was observed that the flow was basically one-dimensional in the nose and flank regions, but three-dimensional flow effects were observed in the outer flank. Additionally, the effects of tiled versus monolithic heatshield models were also investigated. It was observed that the 3D tiled and 3D monolithic configurations yielded relative differences for in-depth material temperature up to 18% and 28%, respectively, when compared to the a 1D model

    Endoscopic Nasobiliary Drainage in the Management of Acute Cholangitis: An Experience in 143 Patients

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    Acute cholangitis is associated with a high mortality and morbidity and often requires drainage of the obstructed biliary system. The purpose of this study was to evaluate the usefulness and safety of endoscopic nasobiliary drainage in the treatment and prevention of acute cholangitis due to diverse etiology. During a 32-month period, 143 patients (67 males, 76 females) with age range of 15 to 84 years underwent urgent fluoroscopy guided endoscopic nasobiliary drainage using a 7 Fr catheter either to treat acute cholangitis not responding to antibiotics (group A, n = 116) or to prevent its development following endoscopic retrograde cholangiography performed in an obstructed biliary system (group B, n = 27). Underlying etiology included bile duct stones (92), malignant biliary obstruction (34), choledochal cyst (4), chronic pancreatitis (4), ruptured hydatid cyst (3), portal hypertensive cholangiopathy (3) and liver abscess (3). Endoscopic nasobiliary drainage was performed successfully in 129 patients (90.2%). Cholangitis improved within 1 to 3 days (in group A) or did not develop (in Group B) in 125 patients (96.7%) with successful endoscopic nasobiliary drainage. Two patients however required additional drainage by percutaneous transhepatic route, while two died inspite of effective endoscopic drainage. Of the 14 patients (9.8%) with failed endoscopic drainage, 9 were managed by surgical decompression or percutaneous transhepatic drainage, 3 died of septicemia. Endoscopic nasobiliary drainage is a safe and effective method to treat patients with acute cholangitis as well as to prevent its development following cholangiography performed in an obstructed biliary system

    Cell-graph mining for breast tissue modeling and classification

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    We consider the problem of automated cancer diagnosis in the context of breast tissues. We present graph theoretical techniques that identify and compute quantitative metrics for tissue characterization and classification. We segment digital images of histopatological tissue samples using k-means algorithm. For each segmented image we generate different cell-graphs using positional coordinates of cells and surrounding matrix components. These cell-graphs have 500-2000 cells(nodes) with 1000-10000 links depending on the tissue and the type of cell-graph being used. We calculate a set of global metrics from cell-graphs and use them as the feature set for learning. We compare our technique, hierarchical cell graphs, with other techniques based on intensity values of images, Delaunay triangulation of the cells, the previous technique we proposed for brain tissue images and with the hybrid approach that we introduce in this paper. Among the compared techniques, hierarchical-graph approach gives 81.8% accuracy whereas we obtain 61.0%, 54.1% and 75.9% accuracy with intensity-based features, Delaunay triangulation and our previous technique, respectively. © 2007 IEEE

    Towards the Prediction of the Mars 2020 Heatshield Material Response

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    Introduction: NASAs next mission to Mars, the Mars 2020, will use the same heatshield of the Mars Science Laboratory (MSL) for thermal protection during entry, descent and landing. The heatshield is a tiled system made of Phenolic Impregnated Carbon Ablators (PICA) blocks [1]. PICA is a lightweight carbon fiber/polymeric resin material that offers excellent performances for protecting probes during planetary entry. The Mars Entry Descent and Landing Instrument (MEDLI) suite on MSL offers unique in-flight validation data for models of atmospheric entry and material response. MEDLI recorded, among others, time-resolved in-depth temperature data of PICA using thermocouple sensors assembled in the MEDLI Integrated Sensor Plugs (MISP). The objective of this work is to compare the thermal response of the MSL heatshield to the MISP flight data. In preparation to Mars 2020 post-flight analysis, the predictive material response capability is benchmarked against MEDLI flight data

    Heatshield Entry Modeling Using a Design, Analysis, and Optimization Toolbox

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    The Mars Science Laboratory (MSL) was protected during its Mars atmospheric entry by an instrumented heatshield that used NASA's Phenolic Impregnated Carbon Ablator (PICA). PICA is a lightweight carbon fiber/polymeric resin material that offers excellent performances for protecting probes during planetary entry. The Mars Entry Descent and Landing Instrument (MEDLI) suite on MSL offers unique in-flight validation data for models of atmospheric entry and material response. MEDLI recorded, among others, time-resolved in-depth temperature data of PICA using thermocouple sensors assembled in the MEDLI Integrated Sensor Plugs (MISP). The objective of this work is to showcase the capability of the Design, Analysis, and Optimization of Thermal Protection Materials (DAOTPM) software. DAO-TPM is a Python based framework that works as a link between mission design, aerothermal and radiative environment computation, Thermal Protection Systems (TPS) microstructure analysis, material response and optimization tools. The toolbox has a Graphical User Interface (GUI) that allows the user to build as well as run the various software and utilities used to design, analyze and optimize a heatshield during atmospheric entry
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