1 research outputs found
The protective effects of aqueous extract of Carica papaya seeds in paracetamol induced nephrotoxicity in male wistar rats
Background: Oxidative stress plays a crucial role in the development of
drug induced nephrotoxicity. The study aimed to determine the
nephroprotective and ameliorative effects of Carica papaya seed
extract in paracetamol-induced nephrotoxicity in rats. Objectives: To
carry out phytochemical screening of Carica papaya, measure serum urea,
creatinine and uric acid and describe the histopathological status of
the kidneys in the treated and untreated groups. Methods: Phytochemical
screening of the extract was done. Thirty two adult male Wistar rats
were divided into four groups (n= 8 in each group). Group A (control)
animals received normal saline for seven days, group B (paracetamol
group) received normal saline, and paracetamol single dose on the 8th
day. Group C received Carica papaya extract (CPE) 500 mg/ kg, and
paracetamol on the 8th day, while group D, rats were pretreated with
CPE 750 mg/kg/day,and paracetamol administration on the 8th day.
Samples of kidney tissue were removed for histopathological
examination. Results: Screening of Carica papaya showed presence of
nephroprotective pytochemicals. Paracetamol administration resulted in
significant elevation of renal function markers. CPE ameliorated the
effect of paracetamol by reducing the markers as well as reversing the
paracetamol-induced changes in kidney architecture. Conclusion: Carica
papaya contains nephroprotective phytochemicals and may be useful in
preventing kidney damage induced by paracetamol