Genome Sequence of Peacock Reveals the Peculiar Case of a Glittering Bird

The unique ornamental features and extreme sexual traits of Peacock have always intrigued scientists and naturalists for centuries. However, the genomic basis of these phenotypes are yet unknown. Here, we report the first genome sequence and comparative analysis of peacock with the high quality genomes of chicken, turkey, duck, flycatcher and zebra finch. Genes involved in early developmental pathways including TGF-β, BMP, and Wnt signaling, which have been shown to be involved in feather patterning, bone morphogenesis, and skeletal muscle development, revealed signs of adaptive evolution and provided useful clues on the phenotypes of peacock. Innate and adaptive immune genes involved in complement system and T-cell response also showed signs of adaptive evolution in peacock suggesting their possible role in building a robust immune system which is consistent with the predictions of the Hamilton–Zuk hypothesis. This study provides novel genomic and evolutionary insights into the molecular understanding toward the phenotypic evolution of Indian peacock

Phosphatidylserine Targets Single-Walled Carbon Nanotubes to Professional Phagocytes In Vitro and In Vivo

Broad applications of single-walled carbon nanotubes (SWCNT) dictate the necessity to better understand their health effects. Poor recognition of non-functionalized SWCNT by phagocytes is prohibitive towards controlling their biological action. We report that SWCNT coating with a phospholipid “eat-me” signal, phosphatidylserine (PS), makes them recognizable in vitro by different phagocytic cells - murine RAW264.7 macrophages, primary monocyte-derived human macrophages, dendritic cells, and rat brain microglia. Macrophage uptake of PS-coated nanotubes was suppressed by the PS-binding protein, Annexin V, and endocytosis inhibitors, and changed the pattern of pro- and anti-inflammatory cytokine secretion. Loading of PS-coated SWCNT with pro-apoptotic cargo (cytochrome c) allowed for the targeted killing of RAW264.7 macrophages. In vivo aspiration of PS-coated SWCNT stimulated their uptake by lung alveolar macrophages in mice. Thus, PS-coating can be utilized for targeted delivery of SWCNT with specified cargoes into professional phagocytes, hence for therapeutic regulation of specific populations of immune-competent cells

Synthesis, Characterisation & Dissociation Constants of 1-(3-Aryl-5-hydroxy-4-isoxazolylazo)-4-sulphonic Acid & Its Derivatives

893-89

Kinetics & Mechanism of Ruthenium(III) & Iridium(III) Catalysed Oxidation of Isopropanol by Phenyl Iodosoacetate

650-65

Generation of a multi-wavelength source spanning the entire C-band by nonlinear spectral broadening of dual-carrier electro-optic frequency combs

We demonstrate a multi-wavelength source with a high repetition rate of 25 GHz, spanning the entire C-band, of which 124 lines lie within 10 dB bandwidth. We exploit the spectral and temporal properties of dual carrier electro-optic combs to simultaneously enhance self-phase modulation (SPM) based broadening and increase the stimulated Brillouin scattering (SBS) threshold. Dual carrier combs are generated through electro-optic modulation of spectrally separated narrow linewidth carriers. They are spectrally broadened in a highly nonlinear fiber after amplification with an in-house built erbium ytterbium co-doped fiber amplifier. The temporal profile of the dual carrier combs consists of significantly narrow pulses (1.4-1.9 ps FWHM) in comparison to the single laser comb (16.5 ps FWHM), increasing the peak power and enhancing the SPM effects. Further, the spectral power is distributed across the comb lines, increasing the SBS threshold and thus the power scalability of the system. These two factors together boost the bandwidth of the spectrally broadened multi-wavelength source

Frequency Offset Locked, Dual Carrier Excitation of Phase modulated, Electro-optic Frequency Combs for Bandwidth Scaling and Nonlinear Spectral Broadening

DWDM with/without superchannel based photonic networks require the use of optical carriers with equalised amplitudes and frequency stabilization of adjacent carriers to realise reliable high bandwidth optical communication systems with high spectral efficiency and long reach. Cascading of electro-optic (EO) modulators is a versatile method for generating tuneable, high repetition rate frequency combs which can be used as sources for the carriers. However, the number of lines produced with this technique is limited by the number of phase modulators. Nonlinear spectral broadening is an attractive option for bandwidth scaling; however, bandwidth scaling of single carrier combs through four wave mixing suffers from unequal comb lines or power limitations due to Brillouin scattering. A simpler technique to increase the number of comb lines would involve using multicarrier excitations for comb generation which would result in a proportional increase in the comb lines. Further, dual-carrier excitation enables an excellent temporal profile for nonlinear spectral broadening. However, since the two carriers have uncorrelated drifts, the resultant frequency combs would be unsuitable for most applications. This issue can be overcome by frequency offset locking the two lasers. Here, we demonstrate frequency offset locking (MHz accuracy) of two diode lasers spaced by 100GHz by using an optical phase locked loop which locks one laser to a RF harmonic of the other. This allows for the generation of frequency comb lines locked to each other even post nonlinear broadening. Using this technique, we demonstrate a 25GHz frequency comb with >90 lines (2THz) in the C-band