Synthesis and regioselective N- and O-alkylation of 3-alkyl-5-phenyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones and 2-phenyl-9-propyl-9H-purin-6(1H)-one with evaluation of antiviral and antitumor activities

3-Alkyl-5-phenyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones were prepared by nitrosative cyclization of the appropriate 5,6-diamino-2-phenylpyrimidin-4(3H)-ones with nitrous acid and were subjected to regioselective alkylation with several alkylating agents in aprotic solvent at different temperature. Simultaneous 6-N- and 7-O-alkylation were observed and the regioselectivity varied remarkably with size and shape of the alkylating agents as well as with the reaction temperature. Similarly, N- and O-alkylation as well as selectivity was also observed in the case of 2-phenyl-9-propyl-9H-purin-6(1H)-one. Some of the synthesized compounds showed moderate antiviral and antitumor activities.</p

Experimental observation of transition behavior on a flat plate

In studying transition behavior a shock tube and tunnel were used to produce high temperatures, and thin-film platinum heat gauges were used to measure local heat flux as well as to detect the transition of the laminar boundary layer over a flat plate and a cone. Initial investigations were conducted in the hypersonic shock tunnel to obtain high-temperature information for the development of an ICBM nose cone. Shock Mach numbers as large as 50 with a temperature of 15,000 K after the incident wave were produced in the driven tube. Shock tubes are used to investigate the heat transfer over various surfaces to 2500 K for the development of future gas turbines

Investigation to optimize the passive shock wave/boundary layer control for supercritical airfoil drag reduction

The passive shock wave/boundary layer control for reducing the drag of 14%-thick supercritical airfoil was investigated in the 3 in. x 15.4 in. RPI Transonic Wind Tunnel with and without the top wall insert at transonic Mach numbers. Top wall insert was installed to increase the flow Mach number to 0.90 with the model mounted on the test section bottom wall. Various porous surfaces with a cavity underneath were positioned on the area of the airfoil where the shock wave occurs. The higher pressure behind the shock wave circulates flow through the cavity to the lower pressure ahead of the shock wave. The effects from this circulation prevent boundary layer separation and enthropy increase hrough the shock wave. The static pressure distributions over the airfoil, the wake impact pressure survey for determining the profile drag and the Schlieren photographs for porous surfaces are presented and compared with the results for solid surface airfoil. With a 2.8% uniform porosity the normal shock wave for the solid surface was changed to a lambda shock wave, and the wake impact pressure data indicate a drag coefficient reduction as much as 45% lower than for the solid surface airfoil at high transonic Mach numbers

Antitumor studies. Part 4: Design, synthesis, antitumor activity, and molecular docking study of novel 2-substituted 2-deoxoflavin-5-oxides, 2-deoxoalloxazine-5-oxides, and their 5-deaza analogs

Various novel 10-alkyl-2-deoxo-2-methylthioflavin-5-oxides and their 2-alkylamino derivatives were prepared by facile nitrosative cyclization of 6-(N-alkylanilino)-2-methylthiopyrimidin-4(3H)-ones followed by nucleophilic replacement of the 2-methylthio moiety by different amines, and acidic hydrolysis of the 2-methylthio moiety afforded the corresponding flavin derivatives. 2-Deoxo-2-methylthio-5-deazaalloxazines and 2-deoxo-2-methylthioalloxazine-5-oxides were also prepared by Vilsmeier reaction and by nitrosation of 6-anilino-2-methylthiopyrimidin-4(3H)-ones, respectively. Then, they were subjected to nucleophilic replacement with appropriate amines to produce the corresponding 2-alkylamino derivatives. Regiospecific N-3-alkylation of 2-deoxo-2-methylthioalloxazine-5-oxides was carried out with various alkylating agents in the usual way, The antitumor activities against CCRF-HSB-2 and KB tumor cells have been investigated in vitro, and many compounds showed promising antitumor activities. Furthermore, AutoDock molecular docking into PTK (PDB: 1t46) has been done for lead optimization of the aforementioned compounds as potential PTK inhibitors

A quantum Monte Carlo study on the superconducting Kosterlitz-Thouless transition of the attractive Hubbard model on a triangular lattice

We study the superconducting Kosterlitz-Thouless transition of the attractive Hubbard model on a two-dimensional triangular lattice using auxiliary field quantum Monte Carlo method for system sizes up to $12\times 12$ sites. Combining three methods to analyze the numerical data, we find, for the attractive interaction of $U=-4t$, that the transition temperature stays almost constant within the band filling range of $1.0 < n < 1.4$, while it is found to be much lower in the $n<1$ region.Comment: RevTeX 6 page

Investigation to optimize the passive shock wave-boundary layer control for supercritical airfoil drag reduction

The optimization of passive shock wave/boundary layer control for supercritical airfoil drag reduction was investigated in a 3 in. x 15.4 in. Transonic Blowdown Wind Tunnel. A 14% thick supercritical airfoil was tested with 0%, 1.42% and 2.8% porosities at Mach numbers of .70 to .83. The 1.42% case incorporated a linear increase in porosity with the flow direction while the 2.8% case was uniform porosity. The static pressure distributions over the airfoil, the wake impact pressure data for determining the profile drag, and the Schlieren photographs for porous surface airfoils are presented and compared with the results for solid-surface airfoils. While the results show that linear 1.42% porosity actually led to a slight increase in drag it was found that the uniform 2.8% porosity can lead to a drag reduction of 46% at M = .81

Sharp flat plate heat transfer in helium at Mach numbers of 22.8 to 86.8 and in corner flow with air at Mach number of 19

Surface heat transfer rates were measured on a sharp flat plate at zero angle of attack in a hypersonic shock tunnel. The density and leading edge Knudsen number were varied to span the continuum to near free molecule regimes. The strong interaction parameter varied from 11 to 16,000 with Knudsen numbers from 0.56 to 17.1 respectively. Local heat transfer rates in the corner flow region produced by the intersection of two perpendicular flat plates with sharp leading edges were determined for various flow densities. The strength of the shock wave from the vertical plate was varied by adjusting the angle of attack from 0 to 5 deg. The unit Reynolds number varied from 1,000 to 17,200 and the Knudsen numbers from 1.6 to 27. The strong interaction parameter varied from 14 to 500

Effect of Carbon-Doping in Bulk Superconducting MgB2 Samples

Bulk superconducting samples of MgB2 were prepared by solid state reaction of stoichiometric quantities of Mg turnings and B in a sealed Ta cylinder at 890 C for 2 hours. The as-synthesized MgB2 samples had a Tc of 39 K, as defined as the onset of diamagnetism. The crystal symmetry was found to be hexagonal with lattice parameters, a=3.0856 A, and c=3.5199 A, similar to the literature values. To study the effect of carbon doping in MgB2, various C-containing samples of x varying from 0 to 1.00 in MgB2-xCx were prepared. Magnetic characterizations indicate that the Tc onset is same for pure and C-doped samples for x = 0.05, and 0.10. However, the shielding signal decreased monotonically with C content, apparently due to the presence of carbon on the grain boundaries that isolates grains and prevents flow of supercurrents on the perimeter.Comment: 10 pages, 3 figure