Impact of oxidative stress on pregnancy outcome in albino rats

Accumulative reports documented that oxidative stress is implicated in many human and animal diseases. However, the reports concerning the effect of oxidative stress on pregnancy outcome are limited and scarce. The objective of this study was to determine the impact of oxidative stress on pregnancy outcome and to assess the antioxidant effect of vitamin C and E on oxidative stress parameters in blood and placental tissue samples in experimental pregnant animals model exposed to oxidative stress. Wister Albino rats were used in this work to investigate the effects of oxidative stress exposure (addition of H2O2 to the drinking water) on pregnancy outcome. Rats were divided into 5 groups, as follows: Group I (included 7 normal pregnant rats which served as control group). Group II (exposed to 1 % H2O2) included 7 pregnant rats, the rats were allowed to become pregnant and received (1% H2O2) in drinking water from day 7th till the day 19th of pregnancy. Group III (exposed to 3% H2O2) included 8 pregnant rats. Same as group 2, but the rats were exposed to a higher concentration of H2O2 (3%) in drinking water. Group IV (included 8 pregnant rats). Pregnant rats received vitamins C and E without induction of oxidative stress. Group V (included 8 pregnant rats).induction of oxidative stress by 1% H2O2 with vitamins supplementation in the pregnant rats. Serum total antioxidants capacity (TAC), serum and placental tissue oxidative stress biomarker; 8-iso prostaglandin F2α (8-Isoprostane) were measured using specific ELISA kits. Also placental tissues of pregnant rats were isolated and put directly in 10% formalin prepared for histopathological examination. Results revealed a significant decrease in the median values of the body weight and total serum antioxidants capacity (TAC) in groups II and III of rats compared with the control group. A significant higher median value of TAC obtained in the groups IV and V when compared with the control group. Significant higher levels of serum and tissue Isoprostane observed in both groups II and III compared with control group. Histopathological, oxidative stress induced macroscopically degenerative with microscopical appearance of vasculitis and hemorrhage within decidua. Data of the present study demonstrated that imbalance oxidative stress status in pregnant rats occurred due to exposure to oxidant, which played an important role in the pathogenesis of abnormal pregnancy outcome. In addition antioxidants supplementation (vitamins E and C) were valuable in reducing this stress

The Blockade Imposed Against Qatar: An Analytical Study of WTO Principles

تسلط هذه الدراسة التحليلية الضوء على النتائج الناجمة عن الحصار المفروض على دولة قطر وانتهاك دول الحصار — المملكة العربية السعودية. دول الإمارات العربية المتحدة، البحرين ومصر- للاتفاقيات التجارية والاقتصادية تحت منطمة التجارة العالمية (WTO). كما أنها تركز على الأسس القانونية للشكاوى التي رفعتها دولة قطر ضد المملكة العربية السعودية. دول الإمارات العربية المتحدة والبحرين. وإجراءات تسوية المنازعات والسلطه القانونية لمنظمة التجارة العالمية (WTO). والاستثناءات الخاصة بالأمن الوطني. فضلا عن المبادئ الأساسية لمعاهدات منطمه التجارة العالمية (WTO) بما فيها الاتفاقية العامة للتعرفة والتجارة الدولية (GATT). الاتفاقية العامة للتجارة في الخدمات (GATS) واتفاقية حقوق الملكية الفكرية المتعلقة بالتجارة (TRIPS).This analytical study sheds light on the consequences of the blockade imposed against Qatar and the violation of the blockading countries – the Kingdom of Saudi Arabia (KSA), the United Arab Emirates (UAE), Bahrain, and Egypt – of trade and economic agreements under the World Trade Organization (WTO). It also focuses on the legal basis of Qatar’s filed complaints against KSA, UAE, and Bahrain, WTO’s Dispute Settlement Procedures and jurisdiction, and the national security exceptions, as well as the main principles of the WTO treaties including General Agreement on Tariffs and Trade (GATT), General Agreement on Trade in Services (GATS), and Trade-Related Aspects of Intellectual Property Rights (TRIPS)

Cerebral Arteriovenous Malformations (cAVMs): What Is New?

Cerebral arteriovenous malformations (cAVMs) are rare congenital anomalies of cerebral blood vessels that result from maldevelopment of the capillary bed, permitting direct communication between cerebral arteries and veins. It usually occurs in the supratentorial area of the brain; however, it can occur anywhere in the brain and spinal cord. Most of the patients with cAVMs present with a variety of complaints such as seizures, intracerebral hemorrhage, headache, and progressive focal neurological deficit. Imaging such as CT, MRI, and angiography plays a vital role in diagnosis, grading, risk assessment, and posttherapeutic follow-up. The multidisciplinary team use three therapeutic modalities in the treatment of cAVMs. This chapter reviews the clinical presentations, diagnosis, classification, and treatment of cAVMs

Al Ain Oases Mapping Project: Qattārah Oasis, past and present (poster)

The Al Ain Oases Mapping Project is a collaboration between the Abu Dhabi Tourism and Culture Authority and Zayed University. It aims to document the present oasis landscape and identify surviving historic components, while at the same time engaging Emirati students with their heritage and building capacity for archaeology in the UAE. The project utilizes a non-intrusive field-walking methodology suitable for a class of undergraduate students. It further draws on the students\u27 community links and bilingualism to contact former residents of the oasis villages and undertake oral history interviews. The first season\u27s work focused on Qattārah Oasis and contributes to the established programme of works there; future seasons will expand the survey to neighbouring Jīmī Oasis and the other oases of al-\u27Ayn. The results will inform continued archaeological exploration of the oases by TCA

Trends in Prevalence of Advanced HIV Disease at Antiretroviral Therapy Enrollment - 10 Countries, 2004-2015.

Monitoring prevalence of advanced human immunodeficiency virus (HIV) disease (i.e., CD4+ T-cell count <200 cells/μL) among persons starting antiretroviral therapy (ART) is important to understand ART program outcomes, inform HIV prevention strategy, and forecast need for adjunctive therapies.*,†,§ To assess trends in prevalence of advanced disease at ART initiation in 10 high-burden countries during 2004-2015, records of 694,138 ART enrollees aged ≥15 years from 797 ART facilities were analyzed. Availability of national electronic medical record systems allowed up-to-date evaluation of trends in Haiti (2004-2015), Mozambique (2004-2014), and Namibia (2004-2012), where prevalence of advanced disease at ART initiation declined from 75% to 34% (p<0.001), 73% to 37% (p<0.001), and 80% to 41% (p<0.001), respectively. Significant declines in prevalence of advanced disease during 2004-2011 were observed in Nigeria, Swaziland, Uganda, Vietnam, and Zimbabwe. The encouraging declines in prevalence of advanced disease at ART enrollment are likely due to scale-up of testing and treatment services and ART-eligibility guidelines encouraging earlier ART initiation. However, in 2015, approximately a third of new ART patients still initiated ART with advanced HIV disease. To reduce prevalence of advanced disease at ART initiation, adoption of World Health Organization (WHO)-recommended "treat-all" guidelines and strategies to facilitate earlier HIV testing and treatment are needed to reduce HIV-related mortality and HIV incidence