Delayed Gratification Behavior Among Elementary School Children: An Intervention Model

In the 1960s, Walter Mischel conducted the first study on delayed gratification behavior (Goleman, 1995; Mischel, Shoda & Rodriquez, 1989). Since then, many other follow-up studies have been done to prove what sociologists call ‘the delayed gratification pattern’ (see Funder, Block & Block; Logue & Chavarro 1992). These studies propose that participants who are able to delay gratification around of the age of four were better adjusted and more dependable during their adult lives. Studies conducted to assist participants who were unable to delay gratification could not be uncovered. In this study, researchers invited parents and teachers to use intervention techniques over a one school year period to shape waiting behavior among 100 first year elementary school children who were unable to delay gratification for 20 minutes in an initial experiment. Eight follow-up experiments/observations were conducted increasing waiting time from 20 minutes by intervals of 5-minutes in each new observation period up to 1 hour one school year later to access whether intervention techniques used by parents and teachers were effective. Using basic descriptions statistics, findings reveal that there was an overall increase of participants’ ability to wait for 20 minutes by 58% at the 4th week, 86% at the 21st week, and 70.96% at the 34th week

Mentorship Experiences of Women Leaders in Adventist Higher Education Institutions

There has been an increase in the rate at which women are being chosen to serve as university presidents at Adventist Higher Education institutions worldwide within the past few years. Notwithstanding that increase, the overall representation of women in that position is still proportionately low. To date, about 22 women have served since we first began operating higher education institutions in 1874. At present, about nine women are serving as presidents of AHEIs; the largest number to be serving at any one time since 1874 when AHEIs were established. Having so few women serving in these top-level positions does not provide opportunities for women to mentor and be mentored by other women. This paper examines the mentorship experiences of seven women who served or are currently serving as presidents of AHEIs prior to the their appointments as presidents. General findings reveal that the mentorship experiences played a critical role in the career advancement of these women leaders; though in the majority of the cases, men mentored these women. It is therefore highly recommended that strategic and deliberate mentorship opportunities be made for women-to-women, in an effort to ensure that more women leaders emerge to serve at AHEIs

Canadian Women Army Corps

Public history poster on Canada’s military past about the Canadian Women Army Corps by students Sandeep Barring, Nadine Joseph, and Linda Dao.https://source.sheridancollege.ca/swfhass_military_posters/1004/thumbnail.jp

Effect of extractives on vibrational properties of African Padauk (Pterocarpus soyauxii Taub.)

International audienceExtractives can affect vibrational properties tanδ (damping coefficient) and E'/ρ (specific Young's modulus) but this is highly dependent on species, compounds, and cellular locations. This paper investigates such effects for African Padauk (Pterocarpus soyauxii Taub.), a tropical hardwood with high extractives content and a preferred material for xylophones. 5 groups of 26 heartwood specimens with large, yet comparable, ranges in vibrational properties were extracted in different solvents. Changes in vibrational properties were set against yields of extracts and evaluation of their cellular location. Methanol (ME) reached most of compounds (13%), located about half in lumen and half in cell-wall. Water solubility was extremely low. tanδ and E'/ρ were very strongly related (R2≥0.93), but native wood had abnormally low values of tanδ, while extraction shifted this relation towards higher tanδ values. ME extracted heartwood became in agreement with the average of many species, and close to sapwood. Extractions increased tanδ as much as 60%, irrespective of minute moisture changes or of initial properties. Apparent E'/ρ was barely changed (+2% to -4%) but, after correcting the mass contribution of extracts, was in fact slightly reduced (down to -10% for high E'/ρ), and increasingly so for specimens with low initial values of E'/ρ

Sexual and Reproductive Health Among Ugandan Youth: 2003-04 to 2012

Purpose Suboptimal sexual and reproductive health (SRH) increases morbidity, mortality, and gender inequity and slows development. In Uganda, youths represent 20% of the population, and the burden of sexually transmitted infections (STIs), including human immunodeficiency virus (HIV), is substantial. Methods We analyzed survey data collected using the lot quality assurance sampling (LQAS) technique from two time periods, 2003–2004 and 2012. We assessed knowledge, behaviors, and access to SRH services of youths aged 15–24 years. Using logistic regression, we examined factors associated with these indicators. Results All indicators have improved between the early and later time period. Youths knowing where to get HIV tests increased from <40% to 80% (both sexes); the number of youths reporting ever having an HIV test increased from 8% to 48% (males) and 10% to 64% (females). Knowledge of other STIs improved but remains low; only half of respondents know signs and symptoms of STIs, and less than half know what action to take when infected. In the late period, 85% of female youths, compared with 93% of males reported knowing where to obtain condoms. The proportion of youths reporting sexual debut before age 15 years decreased, less so for males than that for females. Increased age and level of education are associated with positive change for most indicators. Conclusions Over the last decade, progress has been made toward improving the SRH of young people in Uganda. Further efforts are required to ensure universal access and sufficient health education to facilitate the continued improvement of safe sexual behaviors among youth aged 15–24 years

Mutations in the MTHFR gene are not associated with Methotrexate intolerance in patients with juvenile idiopathic arthritis

BACKGROUND: Methotrexate (MTX) intolerance is a frequent problem of long-term treatment in juvenile idiopathic arthritis (JIA). Mutations in the methylentetrahydrofolate reductase (MTHFR) gene may increase toxicity of MTX, potentially constituting an initial stimulus for this conditioned response. The objective of this study was to investigate the relationship of common MTHFR gene mutations and occurrence of MTX intolerance in pediatric patients with JIA treated with MTX. METHODS: Consecutive JIA patients on at least 3 months of MTX treatment were included in this study. Intolerance to MTX was determined using the Methotrexate Intolerance Severity Score (MISS) questionnaire, and MTX intolerance was defined as MISS values of >= 6. Presence of the two most common mutations in the MTHFR gene (C677T and A1298C) was tested using a PCR assay. Results were analyzed using descriptive and non-parametric statistics. RESULTS: 196 patients were included (73 % female). Of those, 93 (46 %) showed MTX intolerance. 168 patients were genotyped for C677T and A1298C. MTX intolerance was not found to be significantly more frequent among patients with hetero- and homozygous or homozygous mutations C677T or A1298C compared to wild type or heterozygous mutations. Analysis of the correlation between numbers of mutations in these two loci to the MISS score did not yield a statistically significant correlation. CONCLUSION: Mutations in the MTHFR gene were not found to be significantly more frequent in JIA patients intolerant to MTX. Toxicity associated with the MTHFR gene seems to result from mechanisms different to those involved in clinical MTX intolerance

Mutations in the MTHFR gene are not associated with Methotrexate intolerance in patients with juvenile idiopathic arthritis

BACKGROUND: Methotrexate (MTX) intolerance is a frequent problem of long-term treatment in juvenile idiopathic arthritis (JIA). Mutations in the methylentetrahydrofolate reductase (MTHFR) gene may increase toxicity of MTX, potentially constituting an initial stimulus for this conditioned response. The objective of this study was to investigate the relationship of common MTHFR gene mutations and occurrence of MTX intolerance in pediatric patients with JIA treated with MTX. METHODS: Consecutive JIA patients on at least 3 months of MTX treatment were included in this study. Intolerance to MTX was determined using the Methotrexate Intolerance Severity Score (MISS) questionnaire, and MTX intolerance was defined as MISS values of >= 6. Presence of the two most common mutations in the MTHFR gene (C677T and A1298C) was tested using a PCR assay. Results were analyzed using descriptive and non-parametric statistics. RESULTS: 196 patients were included (73 % female). Of those, 93 (46 %) showed MTX intolerance. 168 patients were genotyped for C677T and A1298C. MTX intolerance was not found to be significantly more frequent among patients with hetero- and homozygous or homozygous mutations C677T or A1298C compared to wild type or heterozygous mutations. Analysis of the correlation between numbers of mutations in these two loci to the MISS score did not yield a statistically significant correlation. CONCLUSION: Mutations in the MTHFR gene were not found to be significantly more frequent in JIA patients intolerant to MTX. Toxicity associated with the MTHFR gene seems to result from mechanisms different to those involved in clinical MTX intolerance

A technology platform for in vitro transcription and translation of enzymes in micro compartments

Enzymes are crucial elements of all living cells. As biological catalysts they accelerate chemical reactions without being consumed in the process. The modern bioeconomy strives to identify new enzymes for improved usage in biotechnological applications such as the production of fine chemicals or pharmaceuticals. A promising source for the discovery of new enzymes are metagenomes. As there is no intermediary cultivation step for the extraction of the genetic material necessary, the genetic pool of a metagenome comprises genes of cultivable and non-cultivable microorganisms, which is beneficial for the detection of new enzymes. Here we introduce a new technology platform towards high efficient screening of whole metagenome libraries by combining in vitro compartmentation with a cell-free protein synthesis approach (Figure 1). A key element of this platform is a centrifugal microfluidic cartridge which encapsulates the metagenome library in up to 100’000 monodisperse droplets with a volume of 520 pl. The micro droplets are generated by centrifugal step emulsification (1) and are further transported into a standard reaction tube, decoupling the emulsification from the downstream processing. Based on substrate specificity, droplets with active enzymes are selected and a subsequent sequencing analysis allows the identification of the DNA sequence of these enzymes. The high number of generated micro droplets enables a high-throughput of large libraries and the high coverage increases the chance of finding new or rare enzymes. Compared to traditional approaches, the introduced all-in-one metagenome screening platform decreases screening time to a large extend by replacing heterologous expression with in vitro protein synthesis and massive screening. Further, the selection process minimizes the sequencing and annotation effort. Please click Additional Files below to see the full abstract

Connecting Mentally Ill Detainees in Large Urban Jails with Community Care

Large urban jails have become a collection point for many persons with severe mental illness. Connections between jail and community mental health services are needed to assure in-jail care and to promote successful community living following release. This paper addresses this issue for 2855 individuals with severe mental illness who received community mental health services prior to jail detention in King County (Seattle), Washington over a 5-year time period using a unique linked administrative data source. Logistic regression was used to determine the probability that a detainee with severe mental illness received mental health services while in jail as a function of demographic and clinical characteristics. Overall, 70 % of persons with severe mental illness did receive in-jail mental health treatment. Small, but statistically significant sex and race differences were observed in who received treatment in the jail psychiatric unit or from the jail infirmary. Findings confirm the jail's central role in mental health treatment and emphasize the need for greater information sharing and collaboration with community mental health agencies to minimize jail use and to facilitate successful community reentry for detainees with severe mental illness