Author Correction: Transcriptomic and cellular decoding of regional brain vulnerability to neurogenetic disorders

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Transcriptomic and cellular decoding of regional brain vulnerability to neurogenetic disorders

Abstract: Neurodevelopmental disorders have a heritable component and are associated with region specific alterations in brain anatomy. However, it is unclear how genetic risks for neurodevelopmental disorders are translated into spatially patterned brain vulnerabilities. Here, we integrated cortical neuroimaging data from patients with neurodevelopmental disorders caused by genomic copy number variations (CNVs) and gene expression data from healthy subjects. For each of the six investigated disorders, we show that spatial patterns of cortical anatomy changes in youth are correlated with cortical spatial expression of CNV genes in neurotypical adults. By transforming normative bulk-tissue cortical expression data into cell-type expression maps, we link anatomical change maps in each analysed disorder to specific cell classes as well as the CNV-region genes they express. Our findings reveal organizing principles that regulate the mapping of genetic risks onto regional brain changes in neurogenetic disorders. Our findings will enable screening for candidate molecular mechanisms from readily available neuroimaging data

Shifts in attentional scope modulate event-related potentials evoked by reward

Emotions broaden or narrow the scope of attention in order to facilitate adaptive responses in threatening and rewarding contexts. In the current study, rather than asking how emotions influence attentional scope, we considered the possibility that the relationship between attentional breadth and emotion is bidirectional by asking whether shifts in attentional scope alter emotional processes using an event-related potential (ERP) paradigm. Participants (N = 30) completed a modified version of a Monetary Incentive Delay (MID) task, wherein their attention was either narrowed or broadened as they attempted to win rewards. Behaviorally, narrowing attention improved task performance in the form of reduced errors and increased monetary winnings. During cue processing, narrowing (compared to broadening) attention reduced the Cue-P3 (irrespective of cue type). During feedback processing, narrowing (compared to broadening) attention reduced the Feedback-P3 to monetary wins and increased the Feedback-P2 and the Feedback-P3 to monetary non-wins. Results highlight complexity and bidirectionality in the relationship between attentional scope and affective processes

Ten simple rules for getting the most out of a summer laboratory internship

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Transcriptomic and cellular decoding of regional brain vulnerability to neurogenetic disorders

Neurodevelopmental disorders have a heritable component and are associated with region specific alterations in brain anatomy. However, it is unclear how genetic risks for neurodevelopmental disorders are translated into spatially patterned brain vulnerabilities. Here, we integrated cortical neuroimaging data from patients with neurodevelopmental disorders caused by genomic copy number variations (CNVs) and gene expression data from healthy subjects. For each of the six investigated disorders, we show that spatial patterns of cortical anatomy changes in youth are correlated with cortical spatial expression of CNV genes in neurotypical adults. By transforming normative bulk-tissue cortical expression data into cell-type expression maps, we link anatomical change maps in each analysed disorder to specific cell classes as well as the CNV-region genes they express. Our findings reveal organizing principles that regulate the mapping of genetic risks onto regional brain changes in neurogenetic disorders. Our findings will enable screening for candidate molecular mechanisms from readily available neuroimaging data.Cambridge Philosophical SocietyEPSRC EP/N510129/1Eunice Kennedy Shriver National Institute of Child Health 89-M-006Eunice Kennedy Shriver National Institute of Child Health 08-CH-213Eunice Kennedy Shriver National Institute of Child Health (NIH) 1ZIAMH002949-02Eunice Kennedy Shriver National Institute of Child Health (NIH) ZIA MH002794-13Eunice Kennedy Shriver National Institute of Child Health (NIH) 1-ZIA-HD008898Gates Cambridge TrustNational Institute of Mental HealthNIH Oxford-Cambridge Scholars’ ProgramBritish AcademyMedical Research Council MR/K020706/1Transforming Mental Health MQF17_24Alan Turing Institute funded EPSRC grant EP/N510129/1NIH Bench-to-Bedside gran

COMMON VARIANTS WITHIN THE UBAC2 GENE ARE ASSOCIATED WITH INCREASED RISK OF BEHCET'S DISEASE

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