OPTIMASI METODE SPEKTROFOTOMETRI UNTUK PENENTUAN TIOSIANAT BERDASARKAN PEMBENTUKAN SENYAWA HIDRINDANTIN MENGGUNAKAN OKSIDATOR HIPOKLORIT

ABSTRAK Tiosianat adalah senyawa yang mempunyai sifat goitrogenik. Sifat ini akan menyebabkan gangguan akibat kekurangan iodium (GAKI). Penentuan tiosianat dapat dilakukan dengan mereaksikan ninhidrin 1% dan oksidator hipoklorit membentuk senyawa hidrindantin biru dalam suasana basa. Senyawa hidrindantin biru yang terbentuk dianalisa secara spektrofotometri pada panjang gelombang maksimum 590 nm. Variabel penelitian ini meliputi waktu pengukuran dari 10-40 menit, pH larutan 9-14, dan konsentrasi hipoklorit 0,02-0,2 M sebagai oksidator dalam reaksi oksidasi tiosianat menjadi sianida untuk pembentukan senyawa hidrindantin. Hasil penelitian menunjukkan waktu optimum  reaksi oksidasi tiosianat menjadi sianida untuk pembentukan senyawa hidrindantin adalah 10 menit dan stabil sampai menit ke-20. Reaksi oksidasi tiosianat menjadi sianida dan pembentukan senyawa hidrindantin secara optimum terjadi pada pH 12,5, konsentrasi optimum hipoklorit yang digunakan pada proses oksidasi tiosianat adalah 0,15 M. Kata kunci : GAKI, goitrogenik, hidrindantin, ninhidrin, tiosianat ABSTRACT Thiocyanate is a substance which has goitrogenic properties causing iodine deficiency disorders (IDD). Thiocyanate was oxidized with hypochlorite in alkaline condition in the presence of ninhydrin to form blue colored hydrindantin substance which is analyzed by spectrophotometry at wavelength of 590 nm. In this research the method was optimized towards oxidizing time from 10-40 minutes, pH of solution from 9-14, and hypochlorite concentration from 0.02-0.2 M. The results showed that the optimum time for thiocyanate oxidation was 10 minutes and was stable up to 20 minutes, optimum solution pH of 12.5, and optimum concentration of hypochlorite of 0.15 M.   Keywords: IDD, goitrogenic, hydrindantin, ninhydrin, thiocyanat

Formulasi Transetosome Ekstrak Teh Hijau (Camellia sinensis L. Kuntze) Menggunakan Variasi Konsentrasi Soya Lesitin dan Etanol

Green tea is a herbal plant that can be used to maintain health because of its high antioxidant compounds. Along with the development of pharmaceutical technology, drug delivery systems are also increasingly developing, one of which is transetosomes. The purposes of this study are to determine the effect of variations in the concentration of soy lecithin and ethanol on the characterization of transetosomes. Transetosomes are made using the heat method and formulated in 3 formulations with variations in the concentration of lecithin and ethanol, respectively (F1 0.5: 20, F2 0.6: 25, F3 0.7: 30). Based on the results of the study, obtained the best green tea extract transetosomes is in F3 where the resulting form is Unilamellar Vesicle with a size of 105.96 ± 18.94 nm and polydispersity index 0.36 ± 0.01

Abstracts of the International Halal Science Conference 2023

This book presents the extended abstracts of the selected contributions to the International Halal Science Conference, held on 22-23 August 2023 by the International Institute for Halal Research and Training (INHART), IIUM, Malaysia in collaboration with Halalan Thayyiban Research Centre, University Islam Sultan Sharif (UNISSA), Brunei Darussalam. With the increasing global interest in halal products and services, this conference is timely. Conference Title:  International Halal Science ConferenceConference Acronym: IHASC23Conference Theme: Halal Industry Sustainability Through ScienceConference Date: 22-23 August 2023Conference Venue: International Islamic University (IIUM), MalaysiaConference Organizer: International Institute for Halal Research and Training (INHART), International Islamic University (IIUM), Malaysi