Nuclear factor kappa B as a potential target for pharmacological correction endothelium-associated pathology

The nuclear factor kappa B (NF-κB) is one of transcription factors. A high interest in studying the biological role of the signal system and its contribution to the development of cardiovascular, oncological and autoimmune diseases is obvious. A number of stimuli (proinflammatory cytokines: tumor necrosis factor α, interleukin 1β, ligand CD40 and others) trigger the canonical and non-canonical pathways of NF-κB signaling, which increase the expression of genes regulating synthesis of cytokines and chemokines, cell proliferation and differentiation, angiogenesis, immune reactions and apoptosis. However, pathological activation of NF-κB violates the balance of substances participating in the normal activity of the cardiovascular system. This leads to the development and progression of endothelium-associated pathology and comorbidit

Influence of recombinant erythropoietin on mesenchymal stem cells proliferation and differentiation during cultivation on allogenic bone matrix

Effectiveness of mesenchymal stem cells (MSCs) proliferation and differentiation was studied after addition of medicinal product containing human recombinant erythropoietin (rhEPO) into enriched culture medium with components for osteo- and angiogenesis. Cultivation of mesenchymal stem cells under static conditions using “cocktail” of growth factors and rhEPO allowed to populate allogenic discs-scaffolds with connective tissue formations with the participation of osteoblasts and elongated multicellular structures, which formed after endothelium-like cells fusio

Pleiotropic effects of erythropoietin. Influence of erythropoietin on processes of mesenchymal stem cells differentiation

The article notes that рuman recombinant erythropoietin is characterised as a factor which stimulates differentiation and proliferation of erythroid precursor cells, and as a tissue protective factor. Erythropoietin is one of the most perspective humoral agents which are involved in the preconditioning phenomeno

The influence of the concentration of montmorillonite containing sorbent and pH of the culture medium on the antibiotic sensitivity of Escherichia coli, as well as the effect of ground on growth of Escherichia

The aim of this work was the comparative sensitivity test of E. coli to enrofloxacin and doxycycline and bactericidal action of montmorillonite containing sorbent and its combination with enrofloxacin, as well as the influence of the concentration of the enriched montmorillonite containing sorbent and pH of the culture medium on the antibiotic sensitivity of Escherichia coli. The sensitivity test of Escherichia coli to enrofloxacin, and the combination of enrofloxacin with sorbent was performd by the method of double serial dilutions of drugs in a liquid culture mediu

Test-system for estimation of activity of GSK-3 inhibitors as antihypoxants and differentiation of endothelial progenitors in vitro

A model test-system was developed for validation in vitro of antihypoxic and endothelio-differentiating activity of newly created glycogen synthase kinase-3 inhibitors in comparison with the reference drug β4-thymosi

Particle Motion in Rapidly Oscillating Potentials: The Role of the Potential's Initial Phase

Rapidly oscillating potentials with a vanishing time average have been used for a long time to trap charged particles in source-free regions. It has been argued that the motion of a particle in such a potential can be approximately described by a time independent effective potential, which does not depend upon the initial phase of the oscillating potential. However, here we show that the motion of a particle and its trapping condition significantly depend upon this initial phase for arbitrarily high frequencies of the potential's oscillation. We explain this novel phenomenon by showing that the motion of a particle is determined by the effective potential stated in the literature only if its initial conditions are transformed according to a transformation which we show to significantly depend on the potential's initial phase for arbitrarily high frequencies. We confirm our theoretical findings by numerical simulations. Further, we demonstrate that the found phenomenon offers new ways to manipulate the dynamics of particles which are trapped by rapidly oscillating potentials. Finally, we propose a simple experiment to verify the theoretical findings of this work.Comment: 9 pages, 8 figures, published in PR