Open femoral hernia repair: one skin incision for all

<p>Abstract</p> <p>Background</p> <p>Femoral hernias are relatively uncommon, however they are the most common incarcerated abdominal hernia, with strangulation of a viscus carrying significant mortality. Classically three approaches are described to open femoral hernia repair: Lockwood's infra-inguinal, Lotheissen's trans-inguinal and McEvedy's high approach. Each approach describes a separate skin incision and dissection to access the femoral sac. The decision as to which approach to adopt, predominantly dependent on the suspicion of finding strangulated bowel, is often a difficult one and in our opinion an unnecessary one.</p> <p>Methods</p> <p>We propose a technique for open femoral hernia repair that involves a single skin incision 1 cm above the medial half of the inguinal ligament that allows all of the above approaches to the hernia sac depending on the operative findings. Thus the repair of simple femoral hernias can be performed from below the inguinal ligament. If found, inguinal hernias can be repaired. More importantly, resection of compromised bowel can be achieved by accessing the peritoneal cavity with division of the linea semilunaris 4 cm above the inguinal ligament. This avoids compromise of the inguinal canal, and with medial retraction of the rectus abdominis muscle enables access to the peritoneal cavity and compromised bowel.</p> <p>Discussion</p> <p>This simple technique minimises the preoperative debate as to which incision will allow the best approach to the femoral hernia sac, allow for alteration to a simple inguinal hernia repair if necessary, and more importantly obviate the need for further skin incisions if compromised bowel is encountered that requires resection.</p

Effectiveness of a national quality improvement programme to improve survival after emergency abdominal surgery (EPOCH): a stepped-wedge cluster-randomised trial

Background: Emergency abdominal surgery is associated with poor patient outcomes. We studied the effectiveness of a national quality improvement (QI) programme to implement a care pathway to improve survival for these patients. Methods: We did a stepped-wedge cluster-randomised trial of patients aged 40 years or older undergoing emergency open major abdominal surgery. Eligible UK National Health Service (NHS) hospitals (those that had an emergency general surgical service, a substantial volume of emergency abdominal surgery cases, and contributed data to the National Emergency Laparotomy Audit) were organised into 15 geographical clusters and commenced the QI programme in a random order, based on a computer-generated random sequence, over an 85-week period with one geographical cluster commencing the intervention every 5 weeks from the second to the 16th time period. Patients were masked to the study group, but it was not possible to mask hospital staff or investigators. The primary outcome measure was mortality within 90 days of surgery. Analyses were done on an intention-to-treat basis. This study is registered with the ISRCTN registry, number ISRCTN80682973. Findings: Treatment took place between March 3, 2014, and Oct 19, 2015. 22 754 patients were assessed for elegibility. Of 15 873 eligible patients from 93 NHS hospitals, primary outcome data were analysed for 8482 patients in the usual care group and 7374 in the QI group. Eight patients in the usual care group and nine patients in the QI group were not included in the analysis because of missing primary outcome data. The primary outcome of 90-day mortality occurred in 1210 (16%) patients in the QI group compared with 1393 (16%) patients in the usual care group (HR 1·11, 0·96–1·28). Interpretation: No survival benefit was observed from this QI programme to implement a care pathway for patients undergoing emergency abdominal surgery. Future QI programmes should ensure that teams have both the time and resources needed to improve patient care. Funding: National Institute for Health Research Health Services and Delivery Research Programme

Effectiveness of a national quality improvement programme to improve survival after emergency abdominal surgery (EPOCH): a stepped-wedge cluster-randomised trial

BACKGROUND: Emergency abdominal surgery is associated with poor patient outcomes. We studied the effectiveness of a national quality improvement (QI) programme to implement a care pathway to improve survival for these patients. METHODS: We did a stepped-wedge cluster-randomised trial of patients aged 40 years or older undergoing emergency open major abdominal surgery. Eligible UK National Health Service (NHS) hospitals (those that had an emergency general surgical service, a substantial volume of emergency abdominal surgery cases, and contributed data to the National Emergency Laparotomy Audit) were organised into 15 geographical clusters and commenced the QI programme in a random order, based on a computer-generated random sequence, over an 85-week period with one geographical cluster commencing the intervention every 5 weeks from the second to the 16th time period. Patients were masked to the study group, but it was not possible to mask hospital staff or investigators. The primary outcome measure was mortality within 90 days of surgery. Analyses were done on an intention-to-treat basis. This study is registered with the ISRCTN registry, number ISRCTN80682973. FINDINGS: Treatment took place between March 3, 2014, and Oct 19, 2015. 22 754 patients were assessed for elegibility. Of 15 873 eligible patients from 93 NHS hospitals, primary outcome data were analysed for 8482 patients in the usual care group and 7374 in the QI group. Eight patients in the usual care group and nine patients in the QI group were not included in the analysis because of missing primary outcome data. The primary outcome of 90-day mortality occurred in 1210 (16%) patients in the QI group compared with 1393 (16%) patients in the usual care group (HR 1·11, 0·96-1·28). INTERPRETATION: No survival benefit was observed from this QI programme to implement a care pathway for patients undergoing emergency abdominal surgery. Future QI programmes should ensure that teams have both the time and resources needed to improve patient care. FUNDING: National Institute for Health Research Health Services and Delivery Research Programme

T-tube Jejunostomy Feeding After Pancreatic Surgery: A Safe Adjunct

Patients with pancreatic disease are often malnourished because of biliary and gastric outlet obstruction or the catabolic response to sepsis or cancer. In this study, we reviewed our experience of providing enteral nutrition through a T-tube jejunostomy in these patients. Methods: The records of a consecutive series of 36 patients who had undergone pancreatic operations during the last 4 years were reviewed. Data were collected on preoperative nutritional status and postoperative feeding. Results: All patients had partially hydrolysed feeds administered through a T-tube jejunostomy, placed during pylorus-preserving proximal pancreatoduodenectomy (21 patients), Whipple's procedure (4), debridement of pancreatic necrosis (3), palliative bypass (2), distal pancreatectomy (2), cyst-jejunostomy (3) or accessory sphincteroplasty (1). Tube feeding was employed for a mean of 18 days. There were no related deaths. Eight patients had complications directly attributable to the tube, including blockage (4), dislodgement (2), pericatheter leakage (2) and peritonitis (1). Twenty patients had complications related to feeds that included transient diarrhoea (13), abdominal distension (8), nausea or vomiting (6) and pain (6). Consequently, nitrogen and energy needs were completely fulfilled in only 19 patients. Conclusion: Despite many minor shortcomings, jejunostomy tube feeding appears to be a safe adjunct to pancreatic surgery

Magnetic

The Rahat volcanic field represents one of the widely distributed Cenozoic volcanic fields across the western regions of the Arabian Peninsula. Its human significance stems from the fact that its northern fringes, where the historical eruption of 1256 A.D. took place, are very close to the holy city of Al-Madinah Al-Monawarah. In the present work, we analyzed aeromagnetic data from the northern part of Rahat volcanic field as well as carried out a ground gravity survey. A joint interpretation and inversion of gravity and magnetic data were used to estimate the thickness of the lava flows, delineate the subsurface structures of the study area, and estimate the depth to basement using various geophysical methods, such as Tilt Derivative, Euler Deconvolution and 2D modeling inversion. Results indicated that the thickness of the lava flows in the study area ranges between 100 m (above Sea Level) at the eastern and western boundaries of Rahat Volcanic field and getting deeper at the middle as 300–500 m. It also showed that, major structural trend is in the NW direction (Red Sea trend) with some minor trends in EW direction

Expression Profiling of Proliferation and Apoptotic Markers along the Adenoma-Carcinoma Sequence in Familial Adenomatous Polyposis Patients

Introduction. Familial adenomatous polyposis (FAP) patients have a germline mutation in the adenomatous polyposis coli (APC) gene. The APC protein interacts with beta-catenin, resulting in the activation of the Wnt signalling pathway. This results in alterations in cell proliferation and apoptosis. We investigated the expression of beta-catenin and related proliferation and apoptotic factors in FAP patients, exploring the expression along the adenoma-carcinoma sequence. Methods. The expression of beta-catenin, p53, bcl-2, cyclin-D1, caspase-3, CD10, and Ki-67 proteins was studied by immunohistochemistry in samples of colonic nonneoplastic mucosa (n=71), adenomas (n=152), and adenocarcinomas (n=19) from each of the16 FAP patients. Results. The expression of beta-catenin, caspase-3, cyclin-D1, and Ki-67 was increased in both adenomas and carcinomas in FAP patients, compared with normal mucosa. p53 and CD10 expression was only slightly increased in adenomas, but more frequently expressed in carcinomas. Bcl-2 expression was increased in adenomas, but decreased in carcinomas. Conclusion. This is the first study investigating collectively the expression of these molecules together in nonneoplastic mucosa, adenomas, and carcinomas from FAP patients. We find that beta-catenin and related proliferative and apoptotic factors (cyclin-D1, bcl-2, caspase-3, and Ki-67) are expressed early in the sequence, in adenomas. However, p53 and CD10 are often expressed later in the sequence, in carcinomas

Geothermal Exploration Using Remote Sensing, Surface Temperature, and Geophysical Data in Lunayyir Volcanic Field, Saudi Arabia

Energy consumption worldwide has undergone a recent shift, with hydrocarbons, coal, and new energy sources taking center stage. However, fossil fuels face criticism due to their negative impacts on the environment through air pollution. Geothermal energy is a clean, renewable, and eco-friendly alternative that can be harnessed for power generation. The Lunayyir volcanic field is located in the western part of Saudi Arabia and has been identified as a potential geothermal resource. In this study, a comprehensive analysis of the gravity, magnetic, and land surface temperature data collected over the study area is conducted to investigate the geothermal potential. The gravity data are processed using standard techniques to correct for instrument drift, diurnal variations, and topographic effects and to filter out high-frequency noise. The magnetic data are processed using standard procedures. Analysis of the gravity data shows that the Lunayyir volcanic field is characterized by a series of gravity anomalies, which can be interpreted as indicative of the presence of subsurface geologic structures that are similar in geothermal areas, such as faults, fractures, and intrusions. The magnetic data, on the other hand, show that the volcanic field has a relatively low magnetic susceptibility, which is consistent with the presence of volcanic rocks implying shallow heat sources. Landsat satellite data are utilized to calculate the land surface temperature through the use of GIS software. Additionally, the normalized difference vegetation index (NDVI) is calculated using the near-infrared and red bands of the Landsat satellite. The land surface temperature of the year 2007 shows the relatively high temperature at the surface as compared to 2000 and 2021, which is an indication of volcanic activities in the subsurface. It is suggested that these structures may provide conduits for hot fluids, which could potentially be exploited for geothermal energy production. The obtained results emphasize the importance of combining different geophysical datasets to obtain a better understanding of underground geology and geothermal systems. In general, this study improves the assessment of the Lunayyir volcanic field in the western part of Saudi Arabia for geothermal energy