57 research outputs found
Intravenous regional block is similar to sympathetic ganglion block for pain management in patients with complex regional pain syndrome type I
Zeb2 is essential for Schwann cell differentiation, myelination and nerve repair
Schwann cell development and peripheral nerve myelination require the serial expression of transcriptional activators, such as Sox10, Oct6 (also called Scip or Pou3f1) and Krox20 (also called Egr2). Here we show that transcriptional repression, mediated by the zinc-finger protein Zeb2 (also known as Sip1), is essential for differentiation and myelination. Mice lacking Zeb2 in Schwann cells develop a severe peripheral neuropathy, caused by failure of axonal sorting and virtual absence of myelin membranes. Zeb2-deficient Schwann cells continuously express repressors of lineage progression. Moreover, genes for negative regulators of maturation such as Sox2 and Ednrb emerge as Zeb2 target genes, supporting its function as an inhibitor of inhibitors in myelination control. When Zeb2 is deleted in adult mice, Schwann cells readily dedifferentiate following peripheral nerve injury and become repair cells. However, nerve regeneration and remyelination are both perturbed, demonstrating that Zeb2, although undetectable in adult Schwann cells, has a latent function throughout life
Comparative transcriptomics reveals similarities and differences between astrocytoma grades
Effects of aging and hypertension on endothelium-dependent vascular relaxation in rat carotid artery.
Isolation and characterization of cold-sensitive mutations at the benA, β-tubulin, locus of Aspergillus nidulans
Spatial variation in leaf traits and herbivore community within the beech canopy between two different latitudes
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