Endocrinologic, neurologic, and visual morbidity after treatment for craniopharyngioma

Craniopharyngiomas are locally aggressive tumors which typically are focused in the sellar and suprasellar region near a number of critical neural and vascular structures mediating endocrinologic, behavioral, and visual functions. The present study aims to summarize and compare the published literature regarding morbidity resulting from treatment of craniopharyngioma. We performed a comprehensive search of the published English language literature to identify studies publishing outcome data of patients undergoing surgery for craniopharyngioma. Comparisons of the rates of endocrine, vascular, neurological, and visual complications were performed using Pearson’s chi-squared test, and covariates of interest were fitted into a multivariate logistic regression model. In our data set, 540 patients underwent surgical resection of their tumor. 138 patients received biopsy alone followed by some form of radiotherapy. Mean overall follow-up for all patients in these studies was 54 ± 1.8 months. The overall rate of new endocrinopathy for all patients undergoing surgical resection of their mass was 37% (95% CI = 33–41). Patients receiving GTR had over 2.5 times the rate of developing at least one endocrinopathy compared to patients receiving STR alone or STR + XRT (52 vs. 19 vs. 20%, χ2P < 0.00001). On multivariate analysis, GTR conferred a significant increase in the risk of endocrinopathy compared to STR + XRT (OR = 3.45, 95% CI = 2.05–5.81, P < 0.00001), after controlling for study size and the presence of significant hypothalamic involvement. There was a statistical trend towards worse visual outcomes in patients receiving XRT after STR compared to GTR or STR alone (GTR = 3.5% vs. STR 2.1% vs. STR + XRT 6.4%, P = 0.11). Given the difficulty in obtaining class 1 data regarding the treatment of this tumor, this study can serve as an estimate of expected outcomes for these patients, and guide decision making until these data are available

Controlling wettability of the each side of the PLA fabric through orientation of the working gases (O2 and CH4) during cold plasma treatment

This study aimed to obtain a bifunctional fabric from the point of view of hydrophilicity/hydrophobicity for biomedical applications. To achieve this, both sides of a fabric of polylactic acid (PLA) were subjected to a plasma treatment. While in a side the oxygen was introduced to the other side, simultaneously, was added methane. The plasma treatment was performed at 100 W, 1.8 mbar, during 30 minutes. By Scanning Electron Microscopy (SEM) morphological analysis, it became evident that the fabric side facing the oxygen inlet showed micropittings, while the reverse side had smooth surfaces. Analysis by X-Ray photoelectron spectroscopy (XPS) revealed an increase in the amount of oxygen in the surface of the PLA on both sides of the fabric. The surface function was characterized by measurements of water absorption rate, where it was determined that one fabric side was more hydrophilic than the other side. The results indicated achievement of a bifunctional fabric through orientation of working gases during a plasma treatment.The authors are acknowledging to financial support supplied by CAPES - Brasília/Brazil through of the CAPES/IGC program - CGCI n° 055/2010