American Tools to Control the Illegal Movement of Foreign Origin Archaeological Materials: Criminal and Civil Approaches

This article will focus on the merits of criminal sanctions, under the National Stolen Property Act (NSPA), as applied toward the control of the movement of foreign origin archaeological materials in the United States

Molecular Model of Dynamic Social Network Based on E-mail communication

In this work we consider an application of physically inspired sociodynamical model to the modelling of the evolution of email-based social network. Contrary to the standard approach of sociodynamics, which assumes expressing of system dynamics with heuristically defined simple rules, we postulate the inference of these rules from the real data and their application within a dynamic molecular model. We present how to embed the n-dimensional social space in Euclidean one. Then, inspired by the Lennard-Jones potential, we define a data-driven social potential function and apply the resultant force to a real e-mail communication network in a course of a molecular simulation, with network nodes taking on the role of interacting particles. We discuss all steps of the modelling process, from data preparation, through embedding and the molecular simulation itself, to transformation from the embedding space back to a graph structure. The conclusions, drawn from examining the resultant networks in stable, minimum-energy states, emphasize the role of the embedding process projecting the non–metric social graph into the Euclidean space, the significance of the unavoidable loss of information connected with this procedure and the resultant preservation of global rather than local properties of the initial network. We also argue applicability of our method to some classes of problems, while also signalling the areas which require further research in order to expand this applicability domain

Hf isotopes in zircon from the western Superior province, Canada: Implications for Archean crustal development and evolution of the depleted mantle reservoir

U-Pb and Hf isotopic measurements on zircons from the western Superior province confirm that the area contains at least three distinct terrane types. Juvenile terranes that formed mostly within the time span 2.75-2.68 Ga occupy much of the western Wabigoon subprovince as well as granite-greenstone belts to the south. Juvenile 3.0 Ga terranes that were reworked over the time span 2.7-3.0 Ga occupy the south-central part of the Wabigoon subprovince and the North Caribou block in the Sachigo subprovince. Rocks with mantle extraction ages as old as 3.5 Ga and zircon U-Pb ages extending to 3.3 Ga characterize a third type of terrane represented by the Winnipeg River subprovince. This terrane was strongly reworked during the late Archean. Arc-related magmatism was ongoing at 2.71-2.75 Ga in the different terranes, which probably accreted over the time span 2.71-2.68 Ga. Enriched Hf and high O isotopic signatures in late sanukitoid-suite plutons appear to be correlated, which suggests that assimilation of Mesoarchean crust was an important factor in their magmatic evolution. Enriched Hf isotopic signatures in detrital and igneous zircon from parts of the north-central Wabigoon subprovince support previous suggestions that the Winnipeg River terrane extends eastward beyond the Winnipeg River subprovince. The Winnipeg River subprovince was probably being uplifted and eroded into the Quetico sedimentary basin shortly after 2700 Ma, as shown by detrital zircons with enriched Hf isotopic signatures and Meso- to Paleoarchean ages. The pattern of ages and isotopic signatures from the North Caribou block and the south-central Wabigoon subprovince are similar, suggesting that these terranes are correlative. If so, the south-central Wabigoon terrane may have been tectonically transported from the north. Hf isotopic compositions of zircon from juvenile Archean sources are remarkably consistent and define an average εHf value of +3.5 ± 0.2 for samples with an average age of 2724 Ma and a best estimate of +2.7 ± 0.4 at 3000 Ma. Thus, the Neaoarchean depleted mantle reservoir beneath the Superior province appears to have been isotopically well mixed. εHf values were calculated using a value of 1.865 × 10-5 Ma-1 [Scherer, E., Munker, C., Mezger, K., 2001. Calibration of the Lutetium-Hafnium clock. Science 293, 683-687] for the 176Lu decay constant, which is thus far the best reproduced estimate and the one most consistent with depleted mantle evolution results based on Nd isotopes and Nb/Th ratios. A linear Hf mantle growth curve defined by these values and recent MORB intersects the chondritic Hf growth curve during the early Archean (3.4-4.0 Ga). This could indicate that the earliest formation of significant amounts of enriched crust coincides with ages of the oldest preserved rocks, but such a conclusion is contradicted by evidence from 142Nd and 143Nd in early Archean rocks for significant mantle depletion during the Hadean eon (>4.0 Ga). Both lines of evidence might be reconciled if Hadean enriched crust were largely remixed with its depleted mantle source near the beginning of the Archean, leaving only fragmentary evidence of its existence in the oldest rocks

The impact of fretting wear on structural dynamics: Experiment and simulation

This paper investigates the effects of fretting wear on frictional contacts. A high frequency friction rig is used to measure the evolution of hysteresis loops, friction coefficient and tangential contact stiffness over time. This evolution of the contact parameters is linked to significant changes in natural frequencies and damping of the rig. Hysteresis loops are replicated by using a Bouc-Wen modified formulation, which includes wear to simulate the evolution of contact parameters and to model the evolving dynamic behaviour of the rig. A comparison of the measured and predicted dynamic behaviour demonstrates the feasibility of the proposed approach and highlights the need to consider wear to accurately capture the dynamic response of a system with frictional joints over its lifetime

The impact of fretting wear on structural dynamics: Experiment and simulation

This paper investigates the effects of fretting wear on frictional contacts. A high frequency friction rig is used to measure the evolution of hysteresis loops, friction coefficient and tangential contact stiffness over time. This evolution of the contact parameters is linked to significant changes in natural frequencies and damping of the rig. Hysteresis loops are replicated by using a Bouc-Wen modified formulation, which includes wear to simulate the evolution of contact parameters and to model the evolving dynamic behaviour of the rig. A comparison of the measured and predicted dynamic behaviour demonstrates the feasibility of the proposed approach and highlights the need to consider wear to accurately capture the dynamic response of a system with frictional joints over its lifetime

Association between manganese superoxide dismutase promoter gene polymorphism and breast cancer survival

BACKGROUND: Manganese superoxide dismutase (MnSOD) plays a critical role in the detoxification of mitochondrial reactive oxygen species, constituting a major cellular defense mechanism against agents that induce oxidative stress. A genetic polymorphism in the mitochondrial targeting sequence of this gene has been associated with increased cancer risk and survival in breast cancer. This base pair transition (-9 T > C) leads to a valine to alanine amino acid change in the mitochondrial targeting sequence. A polymorphism has also been identified in the proximal region of the promoter (-102 C>T) that alters the recognition sequence of the AP-2 transcription factor, leading to a reduction in transcriptional activity. The aim of our study was to investigate possible associations of the -102 C>T polymorphism with overall and relapse-free breast cancer survival in a hospital-based case-only study. MATERIALS AND METHODS: The relationship between the MnSOD -102 C>T polymorphism and survival was examined in a cohort of 291 women who received chemotherapy and/or radiotherapy for incident breast cancer. The MnSOD -102 C>T genotype was determined using a TaqMan allele discrimination assay. Patient survival was evaluated according to the MnSOD genotype using Kaplan–Meier survival functions. Hazard ratios were calculated from adjusted Cox proportional hazards modeling. All statistical tests were two-sided. RESULTS: In an evaluation of all women, there was a borderline significant reduction in recurrence-free survival with either one or both variant alleles (CT + TT) when compared with patients with wild-type alleles (CC) (odds ratio, 0.65; 95% confidence interval, 0.42–1.01). When the analysis was restricted to patients receiving radiation therapy, there was a significant reduction in relapse-free survival in women who were heterozygous for the MnSOD -102 genotype (relative risk, 0.40; 95% confidence interval, 0.18–0.86). Similarly, when the homozygous and heterozygous variant genotypes were combined, there remained a significant reduction in relapse-free survival in this group (hazard ratio, 0.42; 95% confidence interval, 0.20–0.87). CONCLUSION: The MnSOD -102 variant allele appears to be associated with an improved recurrence-free survival in all patients, and more dramatically in subjects who received adjuvant radiation therapy