全身麻酔時に発生した小児気管支異物の1例

京都府立医科大学附属北部医療センター　耳鼻咽喉科Department of Otolaryngology, North Medical Center, Kyoto Prefectural University of Medicine6歳、男児。扁桃肥大、睡眠時無呼吸症候群に対して、全身麻酔下にて両側口蓋扁桃摘出術施行予定であったが、麻酔導入のマスク換気時に上顎の乳歯が消失した。挿管前後、術中も発見に至らず、気管支ファイバーにて右上葉気管支B2 に陥頓する乳歯を確認。様々な器具を用いたが、最終的にバスケット鉗子にて摘出できた。その後特に合併症なく4 日後に退院した

N,N-Diethyl-3-toluamide Formulation Based on Ethanol Containing 0.1% 2-Hydroxypropyl-β-cyclodextrin Attenuates the Drug’s Skin Penetration and Prolongs the Repellent Effect without Stickiness

N,N-diethyl-3-toluamide (DEET) is one of the most widely used insect repellents in the world. It was reported that a solution containing 6–30% cyclodextrin (CD) as a solvent instead of ethanol (EtOH) provided an enhancement of the repellent action time duration of the DEET formulation, although the high-dose CD caused stickiness. In order to overcome this shortcoming, we attempted to prepare a 10% DEET formulation using EtOH containing low-dose CDs (β-CD, 2-hydroxypropyl-β-CD (HPβCD), methyl-β-CD, and sulfobutylether-β-CD) as solvents (DEET/EtOH/CD formulations). We determined the CD concentration to be 0.1% in the DEET/EtOH/CD formulations, since the stickiness of 0.1% CDs was not felt (approximately 8 × 10−3 N). The DEET residue on the skin superficial layers was prolonged, and the drug penetration into the skin tissue was decreased by the addition of 0.1% CD. In particular, the retention time and attenuated penetration of DEET on the rat skin treated with the DEET/EtOH/HPβCD formulation was significantly higher in comparison with that of the DEET/EtOH formulation without CD. Moreover, the repellent effect of DEET was more sustained by the addition of 0.1% HPβCD in the study using Aedes albopictus. In conclusion, we found that the DEET/EtOH/HPβCD formulations reduced the skin penetration of DEET and prolonged the repellent action without stickiness

DS_10.1177_0363546518781808 – Supplemental material for Kinematics of Rugby Tackling: A Pilot Study With 3-dimensional Motion Analysis

<p>Supplemental material, DS_10.1177_0363546518781808 for Kinematics of Rugby Tackling: A Pilot Study With 3-dimensional Motion Analysis by Takayuki Kawasaki, Tanabe Yasumasa, Hiroshi Tanaka, Kenji Murakami, Nobukazu Maki, Hiroki Ozaki, Daisaku Hirayama, Masahiro Kunda, Katsuya Nobuhara, Toru Okuwaki and Kazuo Kaneko in The American Journal of Sports Medicine</p