8,182 research outputs found
Social work education, training and standards in the Asia-Pacific region
This article discusses the joint project between the International Association of Schools of Social Work (IASSW) and the International Federation of Social Workers (IFSW) to establish guidelines for the training and standard setting that elucidates what social work represents on a global level. While it is impossible to address all the issues that might be significant in such a large scope, attention is given to the challenges establishing global standards might encounter in a region as diverse as the Asia-Pacific
Universality and properties of neutron star type I critical collapses
We study the neutron star axisymmetric critical solution previously found in
the numerical studies of neutron star mergers. Using neutron star-like initial
data and performing similar merger simulations, we demonstrate that the
solution is indeed a semi-attractor on the threshold plane separating the basin
of a neutron star and the basin of a black hole in the solution space of the
Einstein equations. In order to explore the extent of the attraction basin of
the neutron star semiattractor, we construct initial data phase spaces for
these neutron star-like initial data. From these phase spaces, we also observe
several interesting dynamical scenarios where the merged object is supported
from prompt collapse. The properties of the critical index of the solution, in
particular, its dependence on conserved quantities, are then studied. From the
study, it is found that a family of neutron star semi-attractors exist that can
be classified by both their rest masses and ADM masses.Comment: 13 pages, 12 figures, 1 new reference adde
Adaptation without natural selection
Document is itself an extended abstract
Note: estimating the charge size in explosive forming of sheet metal
Note: Estimating the charge size in explosive forming of sheet metal
In the explosive forming of sheet metal some relatively easy method
of estimating the size of the charge is needed. This short note describes
a method in which the size of the charge is found by equating the work done
in forming the component to that part of the explosive energy available
for doing work on the component ⌠[cont]
If you can't be with the one you love, love the one you're with: How individual habituation of agent interactions improves global utility
Simple distributed strategies that modify the behaviour of selfish individuals in a manner that enhances cooperation or global efficiency have proved difficult to identify. We consider a network of selfish agents who each optimise their individual utilities by coordinating (or anti-coordinating) with their neighbours, to maximise the pay-offs from randomly weighted pair-wise games. In general, agents will opt for the behaviour that is the best compromise (for them) of the many conflicting constraints created by their neighbours, but the attractors of the system as a whole will not maximise total utility. We then consider agents that act as 'creatures of habit' by increasing their preference to coordinate (anti-coordinate) with whichever neighbours they are coordinated (anti-coordinated) with at the present moment. These preferences change slowly while the system is repeatedly perturbed such that it settles to many different local attractors. We find that under these conditions, with each perturbation there is a progressively higher chance of the system settling to a configuration with high total utility. Eventually, only one attractor remains, and that attractor is very likely to maximise (or almost maximise) global utility. This counterintutitve result can be understood using theory from computational neuroscience; we show that this simple form of habituation is equivalent to Hebbian learning, and the improved optimisation of global utility that is observed results from wellknown generalisation capabilities of associative memory acting at the network scale. This causes the system of selfish agents, each acting individually but habitually, to collectively identify configurations that maximise total utility
Dysregulation of Human β-Defensin-2 Protein in Inflammatory Bowel Disease
BACKGROUND:Human beta-defensin-2 (HBD2) is an antimicrobial peptide implicated in the pathogenesis of inflammatory bowel disease (IBD). Low copy number and concomitant low mRNA expression of the HBD2 gene have been implicated in susceptibility to colonic Crohn's Disease (CD). We investigated the colonic distribution of HBD2 mRNA expression, and the contributions of genetic and environmental factors on HBD2 protein production. METHODOLOGY/PRINCIPAL FINDINGS:We examined HBD2 mRNA expression at three colonic locations by microarray analysis of biopsies from 151 patients (53 CD, 67 ulcerative colitis [UC], 31 controls). We investigated environmental and genetic influences on HBD2 protein production using ex vivo cultured sigmoid colon biopsies from 69 patients (22 CD, 26 UC, 21 controls) stimulated with lipopolysaccharide (LPS) and/or nicotine for 24 hours. HBD2 and cytokines were measured in culture supernatants. Using DNA samples from these patients, regions in the HBD2 gene promoter were sequenced for NF-kappaB binding-sites and HBD2 gene copy number was determined. HBD2 mRNA expression was highest in inflamed (vs. uninflamed p = 0.0122) ascending colon in CD and in inflamed (vs. uninflamed p<0.0001) sigmoid colon in UC. HBD2 protein production was increased in inflamed UC biopsies (p = 0.0078). There was no difference in HBD2 protein production from unstimulated biopsies of CD, UC and controls. LPS-induced HBD2 production was significantly increased in CD (p = 0.0375) but not UC (p = 0.2017); this LPS-induced response was augmented by nicotine in UC (p = 0.0308) but not CD (p = 0.6872). Nicotine alone did not affect HBD2 production. HBD2 production correlated with IL8 production in UC (p<0.001) and with IL10 in CD (p<0.05). Variations in the HBD2 promoter and HBD2 gene copy number did not affect HBD2 production. SIGNIFICANCE/CONCLUSIONS:Colonic HBD2 was dysregulated at mRNA and protein level in IBD. Inflammatory status and stimulus but not germline variations influenced these changes
Imaging of Skeletal Metastases in Myxoid Liposarcoma
Unlike other soft tissue sarcomas, myxoid/round cell liposarcoma (MRCL) has a tendency to spread to extrapulmonary sites but bone metastases are thought to be uncommon. In case reports, negative bone scintigraphy has been noted in patients with myxoid/round cell liposarcoma and bone metastases but the prevalence and optimal method of diagnosis of bone metastases in this common subtype of liposarcoma are unclear. In an attempt to answer these questions, data were obtained from a prospective database of patients with sarcoma, including MRCL, and the diagnostic imaging used was examined. A variety of imaging tools were used including plain X-rays, bone scintigraphy, computed tomography (CT), and magnetic resonance imaging (MRI). Eight patients (4.3%) developed skeletal metastases all of which were positive on MRI. Bone scintigraphy was negative in two out of four cases, CT was negative in six out of seven, and X-rays were negative in four. Radiography and CT measure mainly cortical bone involvement, whereas MRI examines bone marrow. When investigating patients with MRCL for bone pain, negative X-rays and bone scans do not rule out bone metastases. In our experience, MRI provides the most sensitive technique for the diagnosis of bone metastases in MRCL
Hydrogen Utilization in the Electricity Sector: Opportunities, Issues, and Challenges
This is a modified version of an opinion piece that was featured in Power Engineering.When the sun is shining and the wind is blowing, solar and wind energy are the lowest cost sources
of electric power in the country. This energy can be used to directly power electrical devices, such as lighting for buildings or charging electric vehicles. It can also be stored in batteries for short term storage or can be used to make hydrogen, which can be stored or put in a pipeline for later use, including users that are a long distance away. On the other hand, natural gas fi red gas turbines are both the lowest cost non-intermittent power source, and the largest source of electric power in the US, at around 40%. Can they continue to evolve and be repurposed to utilize stored hydrogen for electric power
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