Author Correction: Amplitude of travelling front as inferred from 14C predicts levels of genetic admixture among European early farmers.

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A composite window into human history

Over the past decade, the ability to recover whole genomes from ancient remains has emerged as a powerful tool for understanding the human past. From a strictly biological perspective, the sequencing of ancient genomes has resolved the dispute over our evolutionary relationship with Neandertals, revealed the extent of gene flow within and between modern and archaic humans, shed light on genetic and health consequences of this admixture, and uncovered genomic changes in recent human evolution (1). More generally, the results have made clear that over the course of human history, moving and mating have been more the rule than the exception. The possible benefits of ancient DNA (aDNA) research for archaeology are enormous. Why, then, have aDNA approaches to archaeological questions occasionally raised eyebrows among archaeologists (2, 3)

A composite window into human history

Over the past decade, the ability to recover whole genomes from ancient remains has emerged as a powerful tool for understanding the human past. From a strictly biological perspective, the sequencing of ancient genomes has resolved the dispute over our evolutionary relationship with Neandertals, revealed the extent of gene flow within and between modern and archaic humans, shed light on genetic and health consequences of this admixture, and uncovered genomic changes in recent human evolution (1). More generally, the results have made clear that over the course of human history, moving and mating have been more the rule than the exception. The possible benefits of ancient DNA (aDNA) research for archaeology are enormous. Why, then, have aDNA approaches to archaeological questions occasionally raised eyebrows among archaeologists (2, 3)

Serrated polyps of the large intestine: current understanding of diagnosis, pathogenesis, and clinical management

Approximately 30 % of colorectal carcinomas develop via the serrated neoplasia pathway characterized by widespread DNA methylation and frequent BRAF mutation. Serrated polyps represent a heterogeneous group of polyps which are the precursor lesions to serrated pathway colorectal carcinomas. The histological classification of serrated polyps has evolved over the last two decades to distinguish three separate entities: hyperplastic polyp, sessile serrated adenoma (SSA), and traditional serrated adenoma (TSA). The malignant potential of SSAs and TSAs has been clearly demonstrated. SSAs are more challenging to detect by colonoscopy and are likely to account for some interval carcinomas of the proximal colon. Serrated polyposis syndrome is now widely recognized as conferring a high risk of colorectal carcinoma although its cause remains elusive. The current understanding of the actual malignant potential of each serrated polyp subtype is still limited due to the lack of large-scale prospective studies. Patient management guidelines have been recently updated although high-level evidence to support them is still required