Organization of multiprotein complexes at cell–cell junctions

The formation of stable cell–cell contacts is required for the generation of barrier-forming sheets of epithelial and endothelial cells. During various physiological processes like tissue development, wound healing or tumorigenesis, cellular junctions are reorganized to allow the release or the incorporation of individual cells. Cell–cell contact formation is regulated by multiprotein complexes which are localized at specific structures along the lateral cell junctions like the tight junctions and adherens junctions and which are targeted to these site through their association with cell adhesion molecules. Recent evidence indicates that several major protein complexes exist which have distinct functions during junction formation. However, this evidence also indicates that their composition is dynamic and subject to changes depending on the state of junction maturation. Thus, cell–cell contact formation and integrity is regulated by a complex network of protein complexes. Imbalancing this network by oncogenic proteins or pathogens results in barrier breakdown and eventually in cancer. Here, I will review the molecular organization of the major multiprotein complexes at junctions of epithelial cells and discuss their function in cell–cell contact formation and maintenance

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Contents: Part I: Theory. Some History Leading to Design Criteria for Bayesian Prediction; A.C. Atkinson, V.V. Fedorov. Optimal Designs for the Evaluation of an Extremum Point; R.C.H. Cheng, et al. On Regression Experiment Design in the Presence of Systematic Error; S.M. Ermakov. Gröbner Basis Methods in Mixture Experiments and Generalisations; B. Giglio, et al. Efficient Designs for Paired Comparisons with a Polynomial Factor; H. Großmann, et al. On Generating and Classifying All qn-m Regular Designs for Square-Free q; P.J. Laycock, P.J. Rowley. Second-Order Optimal Sequential Tests; M.B. Malyutov, I.I. Tsitovich. Variational Calculus in the Space of Measures and Optimal Design; I. Molchanov, S. Zuyev. On the Efficiency of Generally Balanced Designs Analysed by Restricted Maximum Likelihood; H. Monod. Concentration Sets, Elfving Sets and Norms in Optimum Design; A. Pázman. Sequential Construction of an Experimental Design from an I.I.D. Sequence of Experiments without Replacement; L. Pronzato. Optimal Characteristic Designs for Polynomial Models; J.M. Rodríguez-Díaz, J. López-Fidalgo. A Note on Optimal Bounded Designs; M. Sahm, R. Schwabe. Construction of Constrained Optimal Designs; B. Torsney, S. Mandal. Part II: Applications. Pharmaceutical Applications of a Multi-Stage Group Testing Method; B. Bond, et al. Block Designs for Comparison of Two Test Treatments with a Control; S.M. Bortnick, et al. Optimal Sampling Design with Random Size Clusters for a Mixed Model with Measurement Errors; A. Giovagnoli, L. Martino. Optimizing a Unimodal Response Function for Binary Variables; J. Hardwick, Q.F. Stout. An Optimizing Up-And-Down Design; E.E. Kpamegan, N. Flournoy. Further Results on Optimal and Efficient Designs for Constrained Mixture Experiments; R.J. Martin, et al. Coffee-House Designs; W.G. Müller. (D,t, C)-Optimal Run Orders; L. Tack, M. Vandebroek. Optimal Design in Flexible Models, including Feed-Forward Networks and Nonparametric Regression; D.M. Titterington. On Optimal Designs for High Dimensional Binary Regression Models; B. Torsney, N. Gunduz. Planning Herbicide Dose-Response Bioassays Using the Bootstrap; S.S. Zocchi, C.G. Borges Demétrio. Photo Gallery. Optimum Design 2000: List of Participants