122 research outputs found
Effect of volume expansion with hypertonic- and isotonic saline and isotonic glucose on sodium and water transport in the principal cells in the kidney
Riociguat treatment in patients with chronic thromboembolic pulmonary hypertension: Final safety data from the EXPERT registry
Objective: The soluble guanylate cyclase stimulator riociguat is approved for the treatment of adult patients with pulmonary arterial hypertension (PAH) and inoperable or persistent/recurrent chronic thromboembolic pulmonary hypertension (CTEPH) following Phase
MBS analysis of kinetic structures using ADAMS
p. 2318-2327The present paper considers multibody system (MBS) analysis of kinetic structures using
the software package ADAMS. Deployable, foldable, expandable and reconfigurable
kinetic structures can provide a change in the geometric morphology of the envelope by
contributing to making it adaptable to e.g. changing external climate factors, in order to
improve the indoor climate performance of the building. The derivation of equations of
motion for such spatial mechanical systems is a challenging issue in scientific community.
However, with new symbolic tools one can automatically derive equations in so-called
multibody system (MBS) formalism. The present paper considers MBS modeling of kinetic
architectural structures using the software packages ADAMS. As a result, it is found that
symbolic MBS simulation tools facilitate a useful evaluation environment for MBS users
during a design phase of responsive kinetic structures.Kirkegaard, PH.; Nielsen, SRK. (2010). MBS analysis of kinetic structures using ADAMS. Editorial Universitat Politècnica de València. http://hdl.handle.net/10251/727
Resistance to an herbivore through engineered cyanogenic glucoside synthesis
Tattersall, David B. ; Bak, Soren ; Jones, Patrik R. ; Olsen, Carl Erik ; Nielsen, Jens K. ; Hansen, Mads L. ; Hoj, Peter B. ; Moller, Birger Lindber
Attenuation of cGAS-STING signaling is mediated by a p62/SQSTM1-dependent autophagy pathway activated by TBK1
Negative regulation of immune pathways is essential to achieve resolution of immune responses and to avoid excess inflammation. DNA stimulates type I IFN expression through the DNA sensor cGAS, the second messenger cGAMP, and the adaptor molecule STING. Here, we report that STING degradation following activation of the pathway occurs through autophagy and is mediated by p62/SQSTM1, which is phosphorylated by TBK1 to direct ubiquitinated STING to autophagosomes. Degradation of STING was impaired in p62-deficient cells, which responded with elevated IFN production to foreign DNA and DNA pathogens. In the absence of p62, STING failed to traffic to autophagy-associated vesicles. Thus, DNA sensing induces the cGAS-STING pathway to activate TBK1, which phosphorylates IRF3 to induce IFN expression, but also phosphorylates p62 to stimulate STING degradation and attenuation of the response
Testing Hypotheses in an I(2) Model with Applications to the Persistent Long Swings in the Dmk/$ Rate
Structural Characterization of PNA-DNA Duplexes by NMR. Evidence for DNA in a B-like Conformation
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