PHYTOCHEMICAL ANALYSIS AND ANTIBACTERIAL ACTIVITY OF SWIETENIA MAHAGONI – A HIGHLY MEDICINAL PLANT IN INDIA

The present study was designed to evaluate the phytochemical analysis and antibacterial activity of Swietenia mahagoni leaf extract. The leaf extract was subjected to a variety of phytochemical analysis. The qualitative phytochemical tests exhibited the presence of common phytocompounds like alkaloids, tannins, saponins, phlobatannins, flavanoids, terpenoids and volatile oils as major active constituents. The plant (Swietenia mahagoni) leaf has valuable medicinal uses, hence petroleum ether (18.2g) was found to be a good solvent for the phytochemical and antibacterial study. Similarly, the Methanolic leaf extract of Swietenia mahagoni has highest zone of inhibition on Bacillus subtilis

Perspective on Quark Mass and Mixing Relations

Recent data indicate that $V_{ub}\cong \lambda^4 \cong (0.22)^4$, while $m_t$ seems to be $174$ GeV. The relations $m_d/m_s\sim m_s/m_b \sim \delta \sim \lambda^2 \simeq \vert V_{cb}\vert$ and $m_u/m_c\sim m_c/m_t \sim \delta^2 \sim \lambda^4 \sim \vert V_{ub}\vert$ suggest that %a plausible clean separation of the %origin of the quark mixing matrix: the down type sector is responsible for $\vert V_{us}\vert$ and $\vert V_{cb}\vert$, while $V_{ub}$ comes from the up type sector. Five to six parameters might suffice to account for the ten quark mass and mixing parameters, resulting in specific power series representations for the mass matrices. In this picture, $\delta$ seems to be the more sensible expansion parameter, while $\lambda \cong \sqrt{m_d/m_s} \sim \sqrt{\delta}$ is tied empirically to $(M_d)_{11} = 0$.Comment: 10 pages, ReVtex, no figure

Proton Decay in a Minimal SUSY SO(10) Model for Neutrino Mixings

A minimal renormalizable SUSY SO(10) model with B-L symmetry broken by {\bf 126} Higgs field has recently been shown to predict all neutrino mixings and the ratio $\Delta m^2_{\odot}/\Delta m^2_A$ in agreement with observations. Unlike models where B-L is broken by {\bf 16} Higgs, this model guarantees automatic R-parity conservation and hence a stable dark matter as well as the absence of dim=4 baryon violating operator without any additional symmetry assumptions. In this paper, we discuss the predictions of the model for proton decay induced at the GUT scale. We scan over the parameter space of the model allowed by neutrino data and find upper bounds on the partial lifetime for the modes $\tau(n\to \pi^0\bar{\nu})=~2\tau(p\to \pi^+\bar{\nu})\leq (5.7-13)\times 10^{32}$ yrs and $\tau(n\to K^0\bar{\nu})\leq 2.97\times 10^{33}$ yrs for the average squark mass of a TeV and wino mass of 200 GeV, when the parameters satisfy the present lower limits on $\tau(p\to K^+\bar{\nu})$ mode. These results can be used to test the model.Comment: 17 pages, 6 figures; Minor corrections with improved predictions; references update

The design and in vivo testing of a locally stiffness-matched porous scaffold

An increasing volume of work supports utilising the mechanobiology of bone for bone ingrowth into a porous scaffold. However, typically during in vivo testing of implants, the mechanical properties of the bone being replaced are not quantified. Consequently there remains inconsistencies in the literature regarding ‘optimum’ pore size and porosity for bone ingrowth. It is also difficult to compare ingrowth results between studies and to translate in vivo animal testing to human subjects without understanding the mechanical environment. This study presents a clinically applicable approach to determining local bone mechanical properties and design of a scaffold with similar properties. The performance of the scaffold was investigated in vivo in an ovine model. The density, modulus and strength of trabecular bone from the medial femoral condyle from ovine bones was characterised and power-law relationships were established. A porous titanium scaffold, intended to maintain bone mechanical homeostasis, was additively manufactured and implanted into the medial femoral condyle of 6 ewes. The stiffness of the scaffold varied throughout the heterogeneous structure and matched the stiffness variation of bone at the surgical site. Bone ingrowth into the scaffold was 10.73 ± 2.97% after 6 weeks. Fine woven bone, in the interior of the scaffold, and intense formations of more developed woven bone overlaid with lamellar bone at the implant periphery were observed. The workflow presented will allow future in vivo testing to test specific bone strains on bone ingrowth in response to a scaffold and allow for better translation from in vivo testing to commercial implants

tRNA epitranscriptomics and biased codon are linked to proteome expression in

Among components of the translational machinery, ribonucleoside modifications on tRNAs are emerging as critical regulators of cell physiology and stress response. Here, we demonstrate highly coordinated behavior of the repertoire of tRNA modifications of Plasmodium falciparum throughout the intra-erythrocytic developmental cycle (IDC). We observed both a synchronized increase in 22 of 28 modifications from ring to trophozoite stage, consistent with tRNA maturation during translational up-regulation, and asynchronous changes in six modifications. Quantitative analysis of ~2,100 proteins across the IDC revealed that up- and down-regulated proteins in late but not early stages have a marked codon bias that directly correlates with parallel changes in tRNA modifications and enhanced translational efficiency. We thus propose a model in which tRNA modifications modulate the abundance of stage-specific proteins by enhancing translation efficiency of codon-biased transcripts for critical genes. These findings reveal novel epitranscriptomic and translational control mechanisms in the development and pathogenesis of Plasmodium parasites.Singapore. National Research FoundationSingapore-MIT Alliance (Graduate Fellowship

Leptophobic Character of the Z' in an SU(3)_C x SU(3)_L x U(1)_X model

We show that the extra Z boson predicted within the so-called "3-3-1" model has a leptophobic character, and analyse its effects on Z decay widths and on the t\bar t production cross section in p\bar p collisions at the Fermilab Tevatron. Recent model-independent analysis are applied in order to estimate the contribution of this Z' to the observables that will be measured at LEP2.Comment: 11 pages, REVTeX. To be published in Phys. Lett.

Flavon exchange effects in models with abelian flavor symmetry

In models with abelian flavor symmetry the small mixing angles and mass ratios of quarks and leptons are typically given by powers of small parameters characterizing the spontaneous breaking of flavor symmetry by "flavon" fields. If the scale of the breaking of flavor symmetry is near the weak scale, flavon exchange can lead to interesting flavor-violating and CP violating effects. These are studied. It is found that d_e, mu -> e + gamma, and mu-e conversion on nuclei can be near present limits. For significant range of parameters mu-e conversion can be the most sensitive way to look for such effects.Comment: 19 pages, 5 Postscript figures, LATE

Phenomenological Consequences of Singlet Neutrinos

In this paper, we study the phenomenology of right-handed neutrino isosinglets. We consider the general situation where the neutrino masses are not necessarily given by $m_D^2/M$, where $m_D$ and $M$ are the Dirac and Majorana mass terms respectively. The consequent mixing between the light and heavy neutrinos is then not suppressed, and we treat it as an independent parameter in the analysis. It turns out that $\mu-e$ conversion is an important experiment in placing limits on the heavy mass scale ($M$) and the mixing. Mixings among light neutrinos are constrained by neutrinoless double beta decay, as well as by solar and atmospheric neutrino experiments. Detailed one-loop calculations for lepton number violating vertices are provided.Comment: Revtex file,TRI-PP-94-1,VPI-IHEP-94-1, 23 pages, a compressed for 8 figures is appende

New Higgs signals induced by mirror fermion mixing effects

We study the conditions under which flavor violation arises in scalar-fermion interactions, as a result of the mixing phenomena between the standard model and exotic fermions. Phenomenological consequences are discussed within the specific context of a left-right model where these additional fermions have mirror properties under the new SU(2)_R gauge group. Bounds on the parameters of the model are obtained from LFV processes; these results are then used to study the LFV Higgs decays (H --> tau l_j, l_j = e, mu), which reach branching ratios that could be detected at future colliders.Comment: 12 pages, 2 figures, ReVTex4, graphicx, to be published in Phys. Rev.