Powerful Bivariate Genome-Wide Association Analyses Suggest the SOX6 Gene Influencing Both Obesity and Osteoporosis Phenotypes in Males

Current genome-wide association studies (GWAS) are normally implemented in a univariate framework and analyze different phenotypes in isolation. This univariate approach ignores the potential genetic correlation between important disease traits. Hence this approach is difficult to detect pleiotropic genes, which may exist for obesity and osteoporosis, two common diseases of major public health importance that are closely correlated genetically. was previously found to be essential to both cartilage formation/chondrogenesis and obesity-related insulin resistance, suggesting the gene's dual role in both bone and fat. gene's importance in co-regulation of obesity and osteoporosis

Flexural performance of concrete beams reinforced with steel–FRP composite bars

YesFlexural performance of concrete beams reinforced with steel–FRP composite bar (SFCB) was investigated in this paper. Eight concrete beams reinforced with different bar types, namely one specimen reinforced with steel bars, one with fiber-reinforced polymer (FRP) bars and four with SFCBs, while the last two with hybrid FRP/steel bars, were tested to failure. Test results showed that SFCB/hybrid reinforced specimens exhibited improved stiffness, reduced crack width and larger bending capacity compared with FRP-reinforced specimen. According to compatibility of strains, materials’ constitutive relationships and equilibrium of forces, two balanced situations, three different failure modes and balanced reinforcement ratios as well as analytical technique for predicting the whole loading process are developed. Simplified formulas for effective moment of inertia and crack width are also proposed. The predicted results are closely correlated with the test results, confirming the validity of the proposed formulas for practical use.National Natural Science Foundation of China (51678514), China Postdoctoral Science Foundation (2018M642335), the Science and Technology Project of Jiangsu Construction System (2018ZD047), the Cooperative Education Project of Ministry of Education, China (201901273053), the Blue Project Youth Academic Leader of Colleges and Universities in Jiangsu Province (2020), the Six Talent Peaks Project of Jiangsu Province (JZ038, 2016) and the Yangzhou University Top Talents Support Projec