6,335 research outputs found
Gestational diabetes mellitus- right person, right treatment, right time?
Background: Personalised treatment that is uniquely tailored to an individual’s phenotype has become a key goal of clinical and pharmaceutical development across many, particularly chronic, diseases. For type 2 diabetes, the importance of the underlying clinical heterogeneity of the condition is emphasised and a range of treatments are now available, with personalised approaches being developed. While a close connection between risk factors for type 2 diabetes and gestational diabetes has long been acknowledged, stratification of screening, treatment and obstetric intervention remains in its infancy.
Conclusions: Although there have been major advances in our understanding of glucose tolerance in pregnancy and of the benefits of treatment of gestational diabetes, we argue that far more vigorous approaches are needed to enable development of companion diagnostics, and to ensure the efficacious and safe use of novel therapeutic agents and strategies to improve outcomes in this common condition
The Theory of the Waiver Scale: An Argument Why Parents Should Be Able to Waive Their Children\u27s Tort Liability Claims
Correlated noise in networks of gravitational-wave detectors: subtraction and mitigation
One of the key science goals of advanced gravitational-wave detectors is to
observe a stochastic gravitational-wave background. However, recent work
demonstrates that correlated magnetic fields from Schumann resonances can
produce correlated strain noise over global distances, potentially limiting the
sensitivity of stochastic background searches with advanced detectors. In this
paper, we estimate the correlated noise budget for the worldwide Advanced LIGO
network and conclude that correlated noise may affect upcoming measurements. We
investigate the possibility of a Wiener filtering scheme to subtract correlated
noise from Advanced LIGO searches, and estimate the required specifications. We
also consider the possibility that residual correlated noise remains following
subtraction, and we devise an optimal strategy for measuring astronomical
parameters in the presence of correlated noise. Using this new formalism, we
estimate the loss of sensitivity for a broadband, isotropic stochastic
background search using 1 yr of LIGO data at design sensitivity. Given our
current noise budget, the uncertainty with which LIGO can estimate energy
density will likely increase by a factor of ~4--if it is impossible to achieve
significant subtraction. Additionally, narrowband cross-correlation searches
may be severely affected at low frequencies f < 45 Hz without effective
subtraction.Comment: 16 pages, 8 figure
Hearing Conservation Program For Marching Band Members: A Risk For Noise-Induced Hearing Loss?
Purpose: To examine the risk for noise-induced hearing loss (NIHL) in university marching band members and to provide an overview of a hearing conservation program for a marching band. Method: Sound levels during band rehearsals were recorded and audiometric hearing thresholds and transient otoacoustic emission were measured over a 3-year period. Musician's earplugs and information about hearing loss were provided to the students. The hearing thresholds of other college students were tested as a partial control. Results: There were no significant differences in hearing thresholds between the two groups. During initial testing, more marching band members showed apparent high-frequency notches than control students. Follow-up hearing tests in a subsequent year for the marching band members showed that almost all notches disappeared. Persistent standard threshold shift (STS) across tests was not observed in the band members. Conclusion: Band members showed no evidence of STS or persistent notched audiograms. Because accepted procedures for measuring hearing showed a lack of precision in reliably detecting early NIHL in marching band members, it is recommended that signs of NIHL be sought in repeated measurements compared to baseline audiograms rather than in a single measure (a single notch). A hearing conservation program for this population is still recommended because of lengthy rehearsal times with high sound-level exposure during rehearsals.Communication Sciences and Disorder
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Sphaerodactylus fantasticus
Number of Pages: 8Integrative BiologyGeological Science
NATURAL HISTORY OF LEIOCEPHALUS SEMILINEATUS IN ASSOCIATION WITH SYMPATRIC LEIOCEPHALUS SCHREIBERSII AND AMEIVA LINEOLATA
We examined diet, habitat use, and behavior (focal animal observations of intraspecific interactions, escape behavior, and activity period) of Leiocephalus semilineatus from near Puerto Alejandro, Provincia de Barahona, RepĂşblica Dominicana, and compared some parameters to similar data collected at a site near BanĂ, Provincia de Peravia. Leiocephalus semilineatus is found in sympatry in dry scrub forests at both sites with Ameiva lineolata, an active-foraging teiid of approximately the same size, and at the Puerto Alejandro site with a larger congener, L. schreibersii. Leiocephalus semilineatus and L. schreibersii from Puerto Alejandro exhibited sexual size dimorphism, whereas L. semilineatus from the BanĂ site and A. lineolata did not. Leiocephalus semilineatus spent most of the time motionless; other observed activities were interactions with conspecifics, movement, and feeding. Lizards were active from shortly after sunrise to sundown, although activity peaked in late morning. Mean cloacal temperatures of L. semilineatus did not differ significantly from those of the other two species, but were significantly above ambient temperatures. Reproductive condition of collected specimens was examined and no correlation was found between snout-vent length and egg, follicle, or testis size. Clutch size was 1–2. Diets consisted primarily of invertebrates and did not differ significantly between the three species
The Effect of the Tax Reform Act of 1976 Upon Federal Tax Consequences of Ordinary Transactions in Real Estate
The Effect of the Tax Reform Act of 1976 Upon Federal Tax Consequences of Ordinary Transactions in Real Estate
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