Risk factors in gastric cancer

STATE OF THE ART: Gastric cancer (GC) is still a major health problem worldwide due to its frequency, poor prognosis and limited treatment options. At present prevention is likely to be the most effective means of reducing the incidence and mortality from this disease. The most important etiological factors implicated in gastric carcinogenesis are diet and Helicobacter pylori (H. pylori) infection. High intake of salted, pickled or smoked foods, as well as dried fish and meat and refined carbohydrates significantly increased the risk of developing GC while fibers, fresh vegetables and fruit were found to be inversely associated with GC risk. Epidemiological investigations (retrospective, case-control and prospective) and several meta-analyses have demonstrated that concurrent or previous H. pylori infection is associated with an increased risk of GC in respect to uninfected people. H. pylori colonizes gastric mucosa where it induces a complex inflammatory and immune reaction that on time leads to a severe mucosal damage i.e., atrophy, intestinal metaplasia (IM) and dysplasia. The risk of GC is closely related to the grade and extension of gastric atrophy, IM and dysplasia. PERSPECTIVES AND CONCLUSIONS: Today a plausible program for GC prevention means: (1) a correct dietary habit since childhood increasing vegetables and fruit intake, (2) a decrease of H. pylori spread improving family and community sanitation and hygiene, (3) a search and treat H. pylori strategy in offspring of GC, (4) a search and treat H. pylori strategy in patients with chronic atrophic gastritis and intestinal metaplasia (IM), (5) a careful endoscopic and histologic follow-up if precancerous lesions persist irrespective of H. pylori eradication

Non-Steroidal Anti-Inflammatory Drugs in the Carcinogenesisof the Gastrointestinal Tract

It is estimated that underlying infections and inflammatory responses are linked to 15–20% of all deaths from cancer worldwide. Inflammation is a physiologic process in response to tissue damage resulting from microbial pathogen infection, chemical irritation, and/or wounding. Tissues injured throughout the recruitment of inflammatory cells such as macrophages and neutrophils, generate a great amount of growth factors, cytokines, and reactive oxygen and nitrogen species that may cause DNA damage that in turn predisposes to the transformation from chronic inflammation to neoplasia. Cyclooxygenase (COX), playing a key role in cell homeostasis, angiogenesis and tumourigenesis, may represent the link between inflammation and cancer. Currently COX is becoming a pharmacological target for cancer prevention and treatment

Analysis of Italian Market of Syrah Wine

In order to fully understand Syrah wine market in Italy both supply and demand need to be studied. While supply is analyzed with the simple (benchmarking) comparison of the descriptive statistics between Syrah Italian wines and other high quality red Italian wines, the demand is studied econometrically. A double logarithmic approach has been chosen for its simplicity as well as its mathematical tractability, allowing for direct applicability and replicability at industry level. The information retrieved in these analysis results fundamental for the application of appropriate marketing strategies, in order to set the market efficiency at the margin. Findings show exact relationships allowing for price and marketing targets adjustments. Strengths, Weaknesses, Opportunities and Threats (SWOT) analysis, describing the competitive context and the Syrah wine sub-sector, would have been also important for the focus of this study for completeness purposes. Nonetheless, the aim of this analysis is to furnish valuable information about supply and demand in order to improve marketing efficiency for the Syrah wine. The contribution of this study to the existing knowledge about Syrah wine market is twofold: methodological because it identifies ad hoc methodologies that are easily applicable by the industry to understand such a “thin” market, and informational because results are directly applicable for marketing strategies.Syrah, Demand, Supply, Benchmark

The human gastric microbiota: Is it time to rethink the pathogenesis of stomach diseases?

NTRODUCTION: Although long thought to be a sterile organ, due to its acid production, the human stomach holds a core microbiome. AIM: To provide an update of findings related to gastric microbiota and its link with gastric diseases. METHODS: We conducted a systematic review of the literature. RESULTS: The development of culture-independent methods facilitated the identification of many bacteria. Five major phyla have been detected in the stomach: Firmicutes, Bacteroidites, Actinobacteria, Fusobacteria and Proteobacteria. At the genera level, the healthy human stomach is dominated by Prevotella, Streptococcus, Veillonella, Rothia and Haemophilus; however, the composition of the gastric microbiota is dynamic and affected by such factors as diet, drugs and diseases. The interaction between the pre-existing gastric microbiota and Helicobacter pylori infection might influence an individual's risk of gastric disease, including gastric cancer. CONCLUSIONS: The maintenance of bacterial homeostasis could be essential for the stomach's health and highlights the chance for therapeutic interventions targeting the gastric microbiota, even if gastric pH, peristalsis and the mucus layer may prevent bacteria colonization; and the definition of gastric microbiota of the healthy stomach is still an ongoing challenging task

Italian wine demand and differentiation effect of geographical indications

Purpose – Geographical indications (GIs) provide a strong differentiation tool for firms. Whether this statement is confirmed at aggregate level in terms of market independence of different GIs is not tested yet. The purpose of this paper is to provide demand estimates and elasticities (own‐price and substitution) in order to test this hypothesis and verify the differentiation effect of GIs at aggregate level.Design/methodology/approach – The analysis consists of the application of a quadratic almost ideal demand on a four equation system. Estimates are obtained through an iterated version of a generalized method of moments, which corrects for endogeneity determined by expenditure and prices in case of promotional activities.Findings – Estimates prove the existence of a differentiation effect of GIs in terms of magnitude of elasticities and substitution effects. GIs corresponding to higher quality generate lower price sensitiveness and product substitution, contrarily to wine without GI. Controlled origin denomination (DOC) wine demand results are price sensitive and they substitute for wines of different GI. Controlled and guaranteed origin denomination (DOCG) is the most profitable GI. In fact, because of its inelastic demand, DOCG price could be potentially increased, to a certain extent, without having significant effects on volumes consumed.Research limitations/implications – Foreign wine should also be included in the demand system in order to understand the whole Italian wine market. Data concern retail level demand. The whole market, including hotels, restaurants and catering, should be included to offer a wider set of implications.Practical implications – Marketers and producers could use the information provided by the estimates in order to forecast Italian wine demand. Elasticities and substitution effect provide them with a precise measure of consumers' price sensitiveness, which would be beneficial for their pricing strategies.Originality/value – The paper provides, for the first time, estimates of a demand system relative to GI differentiated Italian wine

New Technologies and Sustainability in The Italian Wine Industry

Abstract The new shape of competition is pushing wine firms to invest into new technologies. Given the growing interests in this area, we provide evidence on the determinants of the adoption of the new technologies industry. On the basis of a survey on Italian companies, the main investments in innovations and their key drivers are investigated. We tested whether firm characteristics impact the adoption as well as absorptive capacity, networking and shared knowledge among firms and research institutions and demand factors. Drivers are explored throughout an econometric model. Results lead to policy implications that could be useful to develop supportive actions to innovation

Drivers of Eco-Innovation in the Italian Wine Industry

The importance of eco-innovations for industry has been rising exponentially in recent years. However, even if recent trends show that firms are increasingly committed to eco-innovations, there is little knowledge on why and how companies integrate environmental sustainability into new product development. In this paper we offer a comprehensive analysis of the drivers of eco-innovation in the Italian wine industry on the basis of a large survey on Italian wine producers. We analyse the impact of firms’ characteristics and their technological and organizational capabilities on the introduction of eco-innovations. The relevance of the drivers in influencing the probability of introducing eco-innovations is measured with a latent class econometric model. Our evidence shows that business characteristics and firms’ scientific search processes and their general innovative behaviour are key drivers of eco-innovation. Therefore, according to our results, firms’ commitment to eco-innovate does not differ substantially from other types of innovation activities

Perceived Technological Regimes: An Empirical Analysis of the Apulian Wine Industry

Technological regimes define the technological environment in which innovative and learning activities take place within each sector of the economy. However, in our view technological regimes must be interpreted and elaborated by each organisation operating in a specific sector in order to be rationally implemented, thus turning into perceived technological regimes. We test this argument on a sample of wine companies in the Apulia region (Italy). We find empirical evidence that the perceived technological regimes exist and that firms’ perceptions tend to vary uniformly across different wine technologies. In addition, we find evidence that different firms’ characteristics have a strong impact on firms’ perceptions both at the aggregate level and when distinct perception groups are identified