A STUDY ON BASIC KNOWLEDGE AND PRACTICES FOR ROAD TRAFFIC SAFETY MEASURES AMONG UNDERGRADUATE MEDICAL STUDENTS OF UTTAR PRADESH

Objectives: The objectives of this study were to assess the knowledge and practices of road traffic safety measures among undergraduate medical students and recommendation to prevent road traffic accident. Methods: It was an institutional-based cross-sectional study among undergraduate medical students who knew driving. Total 138 study subjects were purposively selected from three batches. A self-structured questionnaire based on knowledge and practices related to road traffic safety measures with Yes/No answer pattern. Data were collected, compiled, and analyzed using appropriate software. Results: Overall level of knowledge for road traffic safety measures was good/moderate among 37.7% of medical students each while poor among 24.6% students (more among 1st year/39.3% than 2nd year/19.0%, 3rd year/10.0%) (statistically significant X2 =13.304, p-value=0.01). Road traffic safety practices were followed by students (%), namely, wearing a seat belt while driving/seating in four-wheeler’ by 84.1% and neither keep specified speed limit on road/2.9% nor obey all traffic signals/lights/signs’/2.9%. Few students use mobile phone while driving, namely, 2nd year/19.0% and 3rd year/10.0%. Some students “Not Wear Helmet while driving a two-wheeler”/21.7%; “Wrong overtaking from left side”/17.4%; and “drive even when alcoholic”/4.3% of participants. Conclusions: Knowledge for road traffic rules/regulation was good/moderate among average number of students. Majority of medical students’ obey all traffic rules/light signal and signs while some students still did not follow it; use mobile phone while driving/not stop at zebra crossing and neither use indicators while turning nor keep valid DL. To improve the current scenario, road traffic safety rules/measures should be added in our medical curriculum and there is need of frequent awareness campaign related to road safety measures to change their behavior while driving and save their precious life

Integrated Network Pharmacology and In-Silico Molecular Docking Studies to Unveil Mechanism of Action of Polyphenolic Compounds of Psidium Guajava for The Management of Thrombocytopenia

Despite considerable studies, thrombocytopenia is still affecting millions of people with an increasing rate of morbidity and mortality around the globe. Therefore, we aimed to identify pharmacologically active polyphenolic compounds such as quercetin, apigenin and kaempferol in Psidium guajava for the management of thrombocytopenia using network pharmacology and in-silico molecular docking. The results of ADME/Tox screening revealed that all the polyphenolic compounds possess the drug-likeness activity and were found safe. Moreover, network pharmacology revealed that polyphenolic compounds of Psidium guajava may combat diabetes by acting on key targets, such as MAPK, TP53 and TNF-α which were strongly involved in oxidative stress, inflammatory responses and blood-related parameters involved in thrombocytopenia. Further, a mechanistic approach through molecular docking also supports the strong binding sites of quercetin, apigenin and kaempferol. Conclusively, in-silico ADME, molecular docking and network pharmacology study revealed that identified compounds are safe and pharmacologically effective. These identified compounds could be a great source for the development of new anti-thrombocytopenic drugs in the future

Two new phytosterols from the stem bark of Ficus bengalensis L.

Phytochemical investigation of the methanolic extract of the stem bark of Ficus bengalensis L. (Moraceae) resulted in the isolation of two new phytoconstituents characterized as lanost-5,24-dien-3β-yl-β-d-glucopyranosid-2′-O-yl-docos-11″-enoate (lanostadienylglucosyl cetoleate) (1) and 3β-acetoxy-stigmast-22-en-26-oic acid (bengalensisteroic acid ester) (2) together with the known compounds heneicosanyl cis-octadec-9-enoate (heneicosanyl oleate) (3), urs-12-en-3β-yl acetate (α-amyrin acetate) (4), and lup-20(29)-en-3β-ol (lupeol) (5). The structures of these phytoconstituents have been established on the basis of spectral data analysis, chemical reactions and comparison of literature

New isoquinoline alkaloids from the stem bark of <i style="mso-bidi-font-style:normal">Berberis aristata</i>

1237-1241Phytochemical investigation of the methanolic extract of the stem bark of Berberis aristata (Berberidaceae) yields three new isoquinoline alkaloids characterized as 14β-hydroxy-15β-(3′,4′-dimethoxyphenyl ether)-5,6-methylenedioxy-9(10),11(16)-tetradehydroberbinium 1, 14β-hydroxy-15β-(3′,4′-dimethoxybenzoate)-5,6-methylenedioxy-9(10),11(16)-tetradehydro- 17-one-berbinium 2, and 14β-hydroxy-15β-(3′,4′-dimethoxybenzoate)-5,6-methylenedioxy-9(10),11(16)-tetradehydro-1-one berbinium 3. The structures of these phytoconstituents have been elucidated on the basis of spectral data analysis and chemical reactions