198 research outputs found
Diallyl Disulfide Mitigates DNA Damage and Spleen Tissue Effects After Irradiation
BACKGROUND Several factors found in foods are beneficial to human health and they may contribute to radiation protection. Taking food factors could be an easy way to reduce the effects of radiation after nuclear accidents, as well as secondary radiation risks after cancer radiotherapy or space missions. Here, diallyl disulfide (DADS), a component of garlic oil, was studied for its ability to mitigate radiation damage. MATERIAL AND METHODS We investigated the effects of DADS on micronucleus (MN) formation and apoptosis in HepG2 cells by use of 4-Gy X-ray irradiation. We also assessed the effects of DADS on radiation damage in vivo by evaluating MN formation in bone marrow cells in mice (BALB/c, 8-week-old females) after oral intake of DADS prior to irradiation with 4 Gy. Several tissue effects were also investigated. RESULTS The presence of DADS inhibited MN formation, whereas DADS had no influence on the radiation-induced inhibition of cell cycle progression in HepG2 cells. An increase in apoptosis in HepG2 cells was induced after irradiation, and this effect was stronger in the presence of DADS than in its absence. In mice, when DADS was administered daily for 3 days prior to irradiation, MN formation in irradiated mice was decreased. The decrease in MN formation in mice was greater with 0.5% DADS compared to 1% DADS. Moreover, an increase in spleen weight observed 3 weeks after irradiation was suppressed in mice administered DADS. CONCLUSIONS DADS is a potential radiation-protective agent that effectively mitigates DNA damage, and its effects in the spleen observed after irradiation may be related to inflammation and carcinogenesis
Stress and radiation hematopoietic toxicity
Both radiation and stresses cause detrimental effects on humans. Besides possible health effects resulting directly from radiation exposure, the nuclear plant accident is a cause of social psychological stresses. A recent study showed that chronic restraint-induced stresses (CRIS) attenuated Trp53 functions and increased carcinogenesis susceptibility of Trp53 -heterozygous mice to total-body X-irradiation (TBXI), having a big impact on the academic world and a sensational effect on the public, especially the residents living in radioactively contaminated areas. It is important to investigate the possible modification effects from CRIS on radiation-induced health consequences in Trp53 wild-type (Trp53 wt) animals. Prior to a carcinogenesis study, effects of TBXI on the hematopoietic system under CRIS were investigated in terms of hematological abnormality in the peripheral blood and residual damage in the bone marrow erythrocytes using a mouse restraint model. Five-week-old male Trp53 wt C57BL/6J mice were restrained 6 h per day for 28 consecutive days, and TBXI (4 Gy) was given on the 8th day. Results showed that CRIS alone induced a marked decrease in the red blood cell (RBC) and the white blood cell (WBC) count, while TBXI caused significantly lower counts of RBCs, WBCs and blood platelets, and a lower concentration of hemoglobin regardless of CRIS. CRIS alone did not show any significant effect on erythrocyte proliferation and on induction of micronucleated erythrocytes, whereas TBXI markedly inhibited erythrocyte proliferation and induced a significant increase in the incidences of micronucleated erythrocytes, regardless of CRIS. These findings suggest that CRIS does not have a significant impact on radiation-induced detrimental effects on the hematopoietic system in Trp53 wt mice
Obliquity of an Earth-like planet from frequency modulation of its direct imaged lightcurve: mock analysis from general circulation model simulation
Direct-imaging techniques of exoplanets have made significant progress
recently, and will eventually enable to monitor photometric and spectroscopic
signals of earth-like habitable planets in the future. The presence of clouds,
however, would remain as one of the most uncertain components in deciphering
such direct-imaged signals of planets. We attempt to examine how the planetary
obliquity produce different cloud patterns by performing a series of GCM
(General Circulation Model) simulation runs using a set of parameters relevant
for our Earth. Then we use the simulated photometric lightcurves to compute
their frequency modulation due to the planetary spin-orbit coupling over an
entire orbital period, and attempt to see to what extent one can estimate the
obliquity of an Earth-twin. We find that it is possible to estimate the
obliquity of an Earth-twin within the uncertainty of several degrees with a
dedicated 4 m space telescope at 10 pc away from the system if the stellar flux
is completely blocked. While our conclusion is based on several idealized
assumptions, a frequency modulation of a directly-imaged earth-like planet
offers a unique methodology to determine its obliquity.Comment: 29 pages, 18 figures, accepted for publication in Ap
Observation of daytime changes in boundary layer on a clear and weak-wind summer day in western suburban of Tokyo
Temperature, relative humidity, and wind conditions were observed on a clear, hot, summer day on 6 August 2019, 07:30–15:30 local time (LT), near the surface and in the boundary layer at the Minami-Osawa Campus of Tokyo Metropolitan University in the western suburb of Tokyo, Japan. Vertical wind profiles were obtained by pilot-balloon observations (PBOs) and unmanned aerial vehicle (UAV) observations. PBOs and surface wind observations revealed a southerly wind in the lower boundary layer from 11:00 LT, which became stronger during 12:30– 15:30 LT. Temperature plateaued at 11:00–13:00 LT near the surface, whereas a sharp peak was observed by the UAV in the surface boundary layer at 11:00 LT. Water-vapor mixing ratios were higher in the afternoon than in the morning, with heavy cloud cover after 14:30 LT. Comparison with PBO data indicated that wind-speed estimations based on UAV flight-attitude information are problematic
Outburst of LS V+44 17 Observed by MAXI and RXTE, and Discovery of a Dip Structure in the Pulse Profile
We report on the first observation of an X-ray outburst of a Be/X-ray binary
pulsar LS V +44 17/RX J0440.9+4431, and the discovery of an absorption dip
structure in the pulse profile. An outburst of this source was discovered by
MAXI GSC in 2010 April. It was the first detection of the transient activity of
LS V +44 17 since the source was identified as a Be/X-ray binary in 1997. From
the data of the follow-up RXTE observation near the peak of the outburst, we
found a narrow dip structure in its pulse profile which was clearer in the
lower energy bands. The pulse-phase-averaged energy spectra in the 3100 keV
band can be fitted with a continuum model containing a power-law function with
an exponential cutoff and a blackbody component, which are modified at low
energy by an absorption component. A weak iron K emission line is also
detected in the spectra. From the pulse-phase-resolved spectroscopy we found
that the absorption column density at the dip phase was much higher than those
in the other phases. The dip was not seen in the subsequent RXTE observations
at lower flux levels. These results suggest that the dip in the pulse profile
originates from the eclipse of the radiation from the neutron star by the
accretion column.Comment: 18 pages, 7 figures, accepted for publication in PAS
Long-term Monitoring of the Black Hole Binary GX 339-4 in the High/Soft State during the 2010 Outburst with MAXI/GSC
We present the results of monitoring the Galactic black hole candidate GX
339-4 with the Monitor of All-sky X-ray Image (MAXI) / Gas Slit Camera (GSC) in
the high/soft state during the outburst in 2010. All the spectra throughout the
8-month period are well reproduced with a model consisting of multi-color disk
(MCD) emission and its Comptonization component, whose fraction is <= 25% in
the total flux. In spite of the flux variability over a factor of 3, the
innermost disk radius is constant at R_in = 61 +/- 2 km for the inclination
angle of i = 46 deg and the distance of d=8 kpc. This R_in value is consistent
with those of the past measurements with Tenma in the high/soft state. Assuming
that the disk extends to the innermost stable circular orbit of a non-spinning
black hole, we estimate the black hole mass to be M = 6.8 +/- 0.2 M_sun for i =
46 deg and d = 8 kpc, which is consistent with that estimated from the Suzaku
observation of the previous low/hard state. Further combined with the mass
function, we obtain the mass constraint of 4.3 M_sun < M < 13.3 M_sun for the
allowed range of d = 6-15 kpc and i < 60 deg. We also discuss the spin
parameter of the black hole in GX 339-4 by applying relativistic accretion disk
models to the Swift/XRT data.Comment: 9 pages, 8 figures, accepted for publication in PASJ (Suzaku+MAXI
special issue
A Spectral Study of the Black Hole Candidate XTE J1752-223 in the High/Soft State with MAXI, Suzaku and Swift
We report on the X-ray spectral analysis of the black hole candidate XTE\
J1752--223 in the 2009--2010 outburst, utilizing data obtained with the
MAXI/Gas Slit Camera (GSC), the Swift/XRT, and Suzaku, which work
complementarily. As already reported by Nakahira et al. (2010) MAXI monitored
the source continuously throughout the entire outburst for about eight months.
All the MAXI/GSC energy spectra in the high/soft state lasting for 2 months are
well represented by a multi-color disk plus power-law model. The innermost disk
temperature changed from 0.7 keV to 0.4 keV and the disk flux
decreased by an order of magnitude. Nevertheless, the innermost radius is
constant at 41 km, where is the
source distance in units of 3.5 kpc and the inclination. The multi-color
disk parameters obtained with the MAXI/GSC are consistent with those with the
Swift/XRT and Suzaku. The Suzaku data also suggests a possibility that the disk
emission is slightly Comptonized, which could account for broad iron-K features
reported previously. Assuming that the obtained innermost radius represents the
innermost stable circular orbit for a non-rotating black hole, we estimate the
mass of the black hole to be 5.510.28 , where the correction for the stress-free inner boundary condition
and color hardening factor of 1.7 are taken into account. If the inclination is
less than 49 as suggested from the radio monitoring of transient jets
and the soft-to-hard transition in 2010 April occurred at 1--4% of Eddignton
luminosity, the fitting of the Suzaku spectra with a relativistic
accretion-disk model derives constraints on the mass and the distance to be
3.1--55 and 2.3--22 {\rm kpc}, respectively. This confirms that the
compact object in XTE J1752--223 is a black hole.Comment: 12 pages including 7 figures and 4 tables, accepted for publication
in PAS
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