Bedside index (BISAP) v/s ranson scores in predicting mortality and severity in patients with acute pancreatitis

Objective: To determine the diagnostic accuracy of the bedside index for severity in acute pancreatitis in comparison with Ranson scores in predicting mortalities and severities in patients with acute pancreatitis.Methods: The cross-sectional study was conducted at the Department of Emergency Medicine, Aga Khan University Hospital, Karachi, from July 1, 2017, to January 1, 2018, and comprised patients who presented with acute pancreatitis. The bedside index for severity in acute pancreatitis score was applied in the emergency department and the patients were followed up in ward/intensive care unit where Ranson scores were calculated within the following 48 hours. Both the scores were calculated and compared for the prediction of severity and mortality for each patient. Data was analysed using SPSS 20.Results: Of the 136 patients, 88(64.7%) were males and 48(35.3%) were females. The overall mean age was 42.04±16.42 years (16-75 years), On the basis of two scores, mild and moderate acute pancreatitis was diagnosed in 123(90.4%) and 119(87.5%) patients respectively, while severe condition was diagnosed in 13(9.6%) and 17(12.5%) patients respectively. The bedside index had specificity 94.62% compared to 91.54% for Ranson score; sensitivity 100% vs 100%; negative predictive value 100% vs 100%; positive predictive value 46.15% vs 35.29%; and diagnostic accuracy 94.85% vs 91.91%.Conclusions: The bedside index for severity in acute pancreatitis and Ranson score were both found to be reliable tools in predicting mortalities and severities in patients with acute pancreatitis

ANALGESIC EFFICACY OF COMBINATION OF BILATERAL SUPERFICIAL CERVICAL PLEXUS BLOCK AND STANDARD ANALGESIA WITH STANDARD ANALGESIA ALONE IN PATIENTS UNDERGOING THYROID CANCER SURGERY. A RANDOMISED-CONTROLLED TRIAL

Purpose: This study aimed to determine analgesic efficacy of a combination of bilateral superficial cervical plexus block (BLSCPB) and standard analgesia with standard analgesia alone in patients undergoing thyroid cancer surgery under general anaesthesia.Materials and Methods: It was a randomised-controlled trial conducted at the Anaesthesia Department of the Shaukat Khanum Memorial Cancer Hospital, Lahore. A sample size of 60 patients (30 patients in each group) was calculated with 95% confidence interval and power of 80%.Results: The mean pain-free duration for the Group A (BLSCPB group) was 72 min (SD 30.1) compared to 53 min (standard deviation 30.3) for the Group B. This shows a significant reduction in pain-free duration in Group A. Average NRS pain score in the Group A at q 0, 30, 60, 90 and 120 min was (0.83, 1.83, 0.23, 1.76 and 1.49), whereas the average pain score on NRS in the Group B at the same time interval mentioned above for Group A was (2.1, 2.73, 4.53, 2.44 and 1.85)Conclusion: Administration of BLSCPB resulted in superior analgesia after thyroid cancer surgery.Key words: Analgesia, cervical plexus block, post-operative pain, regional anaesthesia, thyroidectom

Efficacy of Enamel Matrix Derivative in Vital Pulp Therapy: A Review of Literature

Introduction: Vital pulp therapy (VPT) aims to preserve the health and maintain life of the tooth pulp which has been compromised by caries, trauma or restorative procedures. Recently, enamel matrix derivative (EMD) has been introduced as a material for vital pulp therapy. The aim of this review is to critically analyze and summarize the available literature on EMD for VPT. Methods and Materials: Online databases (PubMED/MEDLINE, Google Scholar, ISI Web of Science, and Wiley-Online) were searched by using the following keywords in various combinations: Enamel Matrix Derivative, Emdogain, ‘Vital Pulp Therapy, ‘Apexogenisis’, Apexification, Pulp Capping, Endodontics, Dentine and Pulpotomy for studies indexed from January 1949 to April 2016. We used an English-limited search in Google.co.uk for the missing grey literature. All studies fulfilling the selection criteria were carefully reviewed for the focused question: “Does using EMD in VPT, compared with other materials, result in better clinical, radiographic and histological outcomes?”. Results: The primary search resulted in 18 articles of which, 14 articles (including 6 animal studies and 6 clinical trials and 2 case reports) met the inclusion criteria for this review and hence were included. The number of teeth tested in the animal studies ranged from 8 to 144 including pigs, rats and dogs teeth. A number of studies used EMD in the experimental group in comparison with calcium hydroxide, propylene glycol alginate (PGA) and MTA as a control. The observation period ranged from 1 to 2 months and 4 out of 6 animal trials reported more favorable outcomes with EMD while two studies reported comparable outcomes. Conclusion: Although EMD has potential for various applications in endodontics, studies conducted to date have failed to demonstrate any significant advantage of EMD over conventional VPT materials. Additionally, the 5-year and 10-year survival rate of EMD-treated teeth is not yet known. Hence, studies with a longer follow-up periods are required to deduce the long-term viability of teeth treated with EMD.Keywords: Enamel Matrix Derivative; Pulp Capping; Pulpotomy; Root Canal; Vital Pulp Therap

Nanomodified Peek Dental Implants: Bioactive Composites and Surface Modification—A Review

published_or_final_versio

Image Quality Assessment using Image Details in Frequency Domain

This research proposes a RR (Reduced Reference) DIQAM (Detailed Image Quality Assessment Meter) for DCT (Discrete Cosine Transform) based compressed images. DCT technique divides image in sub blocks to achieve image compression.Therefore, it degrades the IQ (Image Quality) by introducing the distortions called blockiness and blurriness in the compressed image.In the telecommunication systems scenario, the systems available bandwidth is limited. The proposed IQ assessment technique requires fewer image details parameters called RR parameters at the receiver, rather than the complete reference image. This paper suggests a method for receiving end to estimate the objective quality of the received image in frequency domain.The proposed IQ meter starts by taking the image through edge detection method, then converting it into frequency domain by Fourier transform and estimating the image details. The image details calculations include the vertical and horizontal ac harmonics as well as all other ac coefficients present in the image. It has been shown in the presented work that using dc coefficients with the other ac coefficients further improves the quality assessment.The calculated strength of coded image details at receiver is compared with the received RR parameter for the estimation of distortions, blockiness and blurriness. The accuracy of the designed RR DIQAM algorithm is proved by correlating the estimated objective values of the distortions with the LIVE image database2 subjective DMOS values of blockiness and blurriness. The results obtained by the proposed technique are well matched with the LIVE database values and provide 94-96% correlation

Evolution of Minimally Invasive Adrenal Surgery at a Tertiary Care Centre in Oman

Objective: We reviewed the case records of adrenalectomy cases at our institution between January 2010 and December 2020 and report the outcomes of both open and laparoscopic adrenalectomy (LA). Methods: This retrospective study included patients who underwent adrenal surgery from January 2010 to December 2020. We recorded demographic details, indications, surgical approach, intra operative data and complications. The final pathology and outcome at the last follow up was also documented. Data was analyzed through the SPSS program. Results: Fifty two patients underwent 61 adrenalectomy procedures. Six patients had bilateral procedure and 3 patients underwent redo surgery accounting for 55 subjects. Open adrenalectomy (OA) was performed on 11 patients and 44 patients underwent LA. Majority of the patients (27) were obese having BMI > 30. Functional adenoma was excised in 36 patients with final diagnosis of Conn’s syndrome in 15, Pheochromocytoma in 13 and Cushing syndrome in 9 patients. Five patients had surgery for oncological indications. Nonfunctional adenoma was excised in 13 patients, with a mean size of 8.9 cm (range 4-15 cm). The mean duration of surgery was less in laparoscopic procedure (199 min) compared to open (246 min). The mean estimated blood loss in LA was significantly less (108ml vs 450 ml, p-value < 0.05). Out of 55 subjects only 1 patients developed Clavien-dindo grade 2 complication. Conclusion: At our institution both laparoscopic and open adrenalectomy were safely performed. There is a trend to perform LA and with experience the duration of surgery and EBL are demonstrating positive trend. Keywords: Adrenal Gland Surgery; Laparoscopic Adrenalectomy; Open Adrenalectomy; Pheochromocytoma; Adrenal Metastasis; Nonfunctional Adrenal Tumors; Oman

Genome-wide analysis of the maternal-to-zygotic transition in Drosophila primordial germ cells

Background: During the maternal-to-zygotic transition (MZT) vast changes in the embryonic transcriptome are produced by a combination of two processes: elimination of maternally provided mRNAs and synthesis of new transcripts from the zygotic genome. Previous genome-wide analyses of the MZT have been restricted to whole embryos. Here we report the first such analysis for primordial germ cells (PGCs), the progenitors of the germ-line stem cells. Results: We purified PGCs from Drosophila embryos, defined their proteome and transcriptome, and assessed the content, scale and dynamics of their MZT. Transcripts encoding proteins that implement particular types of biological functions group into nine distinct expression profiles, reflecting coordinate control at the transcriptional and posttranscriptional levels. mRNAs encoding germ-plasm components and cell-cell signaling molecules are rapidly degraded while new transcription produces mRNAs encoding the core transcriptional and protein synthetic machineries. The RNA-binding protein Smaug is essential for the PGC MZT, clearing transcripts encoding proteins that regulate stem cell behavior, transcriptional and posttranscriptional processes. Computational analyses suggest that Smaug and AU-rich element binding proteins function independently to control transcript elimination. Conclusions: The scale of the MZT is similar in the soma and PGCs. However, the timing and content of their MZTs differ, reflecting the distinct developmental imperatives of these cell types. The PGC MZT is delayed relative to that in the soma, likely because relief of PGC-specific transcriptional silencing is required for zygotic genome activation as well as for efficient maternal transcript clearance.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000305391700004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701Biotechnology & Applied MicrobiologyGenetics & HereditySCI(E)20ARTICLE2null1

Machine Learning at Microsoft with ML .NET

Machine Learning is transitioning from an art and science into a technology available to every developer. In the near future, every application on every platform will incorporate trained models to encode data-based decisions that would be impossible for developers to author. This presents a significant engineering challenge, since currently data science and modeling are largely decoupled from standard software development processes. This separation makes incorporating machine learning capabilities inside applications unnecessarily costly and difficult, and furthermore discourage developers from embracing ML in first place. In this paper we present ML .NET, a framework developed at Microsoft over the last decade in response to the challenge of making it easy to ship machine learning models in large software applications. We present its architecture, and illuminate the application demands that shaped it. Specifically, we introduce DataView, the core data abstraction of ML .NET which allows it to capture full predictive pipelines efficiently and consistently across training and inference lifecycles. We close the paper with a surprisingly favorable performance study of ML .NET compared to more recent entrants, and a discussion of some lessons learned

Abscisic acid-dependent and -independent expression of the carrot LEA class gene Dc3 in transgenic tobacco seedlings

Due to the character of the original source materials and the nature of batch digitization, quality control issues may be present in this document. Please report any quality issues you encounter to [email protected], referencing the URI of the item.Includes bibliographical references.Issued also on microfiche from Lange Micrographics.We studied the expression of three promoter deletion mutants (A218, A599, and A1312) of the Late Embryo Abundant (LEA) class gene Dc3 fused to the reporter gene, B-glucuronidase (GUS) in 14 d old transgenic tobacco seedlings. Seedlings were subjected to one of the following stresses: dehydration, hypoxia, salinity, exogenous ethylene, and exogenous methyl jasmonate (MeJa). GUS activity was quantified fluorometrically, and expression was observed by histochemical staining of the seedlings. An increase in GUS activity was observed in A599 and A1312 mutants in response to dehydration and salinity within 6 h of stress, and at 12 h in response to hypoxia. No increase in endogenous ABA was found in any of the three mutants even after 24 h of hypoxia. ABA-independent increase in GUS activity was observed when endogenous ABA biosynthesis was blocked by fluridone and plants were exposed to 5 [[ ]-' ethylene in air or 100 @M MeJa. No expression was observed in A218 mutant in response to dehydration, salinity, or MeJa. A mild response was observed in response to ethylene or hypoxia. This suggests that the region between-218 and-599 is absolutely necessary for ABA (dehydration and salinity) and MeJa-dependent expression whereas ethylene mediated expression does not require this region of the promoter. This study shows that Dc3, which is an ABA responsive gene, can also be induced by stress signals other than ABA

آزاد انصاری: مقلدِ حالی

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mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin-top:0in; mso-para-margin-right:0in; mso-para-margin-bottom:10.0pt; mso-para-margin-left:0in; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:Arial; mso-bidi-theme-font:minor-bidi;} In this essay the prose and  poetry of Hakeem Azad Ansari has been viewed in the prospect of Hali. What were the conditions and atmosphere prevailed in the life of Azad Ansari and how he firmly followed the instructions of the poet Hali firmly.  Who so ever are the followers of poet Hali in which  the status of Azad Ansari is prominent. In this Essay it has been visualized that how poetry and prose Azad Ansari totally and fully followed Hali in the Art of Criticism.</p