Drainage Morphology Approach For Water Resources Development of Sub Watershed in Krishna Basin

The morphometric analysis of study area has been carried out using Arc GIS software. The study area covers 3035 sq.km. The drainage network was delineated using SOI topographical map of no. 47 K – 5, 6, 7, 8, 10, 11, 12, 47 L - 9 on the scale 1:50,000. Morphological characterized of the drainage line as appear in shape ,size, number, order, length, Dd, Sf, Rb, Fs, T, Rc are derived to trace its usefulness for surface development . The present study involves Geographic Information System (GIS) analysis technique to evaluate and compare linear relief and aerial morphometry of Yerala watershed of Krishna River. Yerala watershed is basically 7th order drainage and is mainly dendritic to sub dendritic. Drainage density and texture of the drainage basin is 6.89 km/km2, 18.60 respectively. The drainage frequency of Yerala watersheds is 1.96 where as the bifurcation ratio ranges from 2 to 11. Hence from the study it can be conclude that GIS technique proves to be competent tool in morphometric analysis

Role of Higher Multipole Excitations in the Electromagnetic Dissociation of One Neutron Halo Nuclei

We investigate the role of higher multipole excitations in the electromagnetic dissociation of one-neutron halo nuclei within two different theoretical models -- a finite range distorted wave Born approximation and another in a more analytical method with a finite range potential. We also show, within a simple picture, how the presence of a weakly bound state affects the breakup cross section.Comment: 8 pages, 9 figure

Magnetic Properties of Ternary Gallides of type RNi4Ga (R = Rare earths)

The magnetic properties of RNi4Ga (R = La, Pr, Nd, Sm, Gd, Tb, Dy, Ho, Er, Tm and Lu) compounds have been investigated. These compounds form in a hexagonal CaCu5 type structure with a space group P6/mmm. Compounds with the magnetic rare earths, R = Nd, Sm, Gd, Tb, Dy, Ho, Er and Tm, undergo a ferromagnetic transition at 5 K, 17 K, 20 K, 19 K, 12 K, 3.5 K, 8 K and 6.5 K, respectively. The transition temperatures are smaller compared to their respective parent compounds RNi5. PrNi4Ga is paramagnetic down to 2 K. LaNi4Ga and LuNi4Ga are Pauli paramagnets. All the compounds show thermomagnetic irreversibility in the magnetically ordered state except GdNi4Ga.Comment: 14 Pages 6 Figures 1 Tabl

Antigenic competition among different ‘O’ antigens of <i style="">Salmonella enterica</i> subspecies <i style="">enterica</i> serovars during hyperimmunization in pony mares

1022-1025The present study on antigenic competition among somatic ‘O’ antigens of different Salmonella groups (A, B, C1, C2, D and E1) in mares revealed that the immune response to most of the antigens was not (A, B, C2) or little (C1, D) affected by antigenic competition. However, E1 group antigen, which induced high antibody titres (Avg. 12967.3) when given alone, produced almost 3.5 log2 lower antibody titres on giving with other antigens, indicating the antigenic competition among some Salmonella group antigens. The antigenic competition varied for different antigens even of the similar chemical nature. Therefore, antigens belonging to different somatic groups should not be given together for the purpose of raising polyvalent serum or for immunization using multivalent Salmonella vaccines prepared from strains of different ‘O’ groups revealing antigenic competition

In vitro and in vivo activities of the nitroimidazole CGI 17341 against Mycobacterium tuberculosis

CGI 17341 (2-ethyl-5-nitro-2,3-dihydro[2-1b]imidazo-oxazole) is a novel orally active representative of the 5-nitroimidazole series of antimicrobial agents. At concentrations ranging from 0.1 to 0.3 micrograms/ml, CGI 17341 inhibited the drug-susceptible and multi-drug-resistant strains of Mycobacterium tuberculosis. CGI 17341 had no cross-resistance with isoniazid, rifampin, streptomycin, or ethambutol. While the in vitro activity of CGI 17341 against M. tuberculosis was comparable to those of isoniazid and rifampin, it was superior to those of streptomycin, ciprofloxacin or norfloxacin, and oxazolidinone DuP 721. The MIC of CGI 17341 was not affected when the pH of the medium was decreased from 6.8 to 5.6, while four- to sixfold increases in the MICs of ciprofloxacin and isoniazid were observed. In mice infected with M. tuberculosis, the 50% effective dose for CGI 17341 was 7.7 mg/kg of body weight (95% confidence limits, 3.5 and 10.27) when administered on days 11 and 12 postinfection. CGI 17341 gave a dose-dependent (r = 0.995) and significant increase in the survival time. Our data indicate that the 5-nitroimidazole CGI 17341 is a promising and novel antituberculosis compound with potent in vitro and in vivo activities. Further investigations on this compound are warranted

Novel integrative genomic tool for interrogating lithium response in bipolar disorder

We developed a novel integrative genomic tool called GRANITE (Genetic Regulatory Analysis of Networks Investigational Tool Environment) that can effectively analyze large complex data sets to generate interactive networks. GRANITE is an open-source tool and invaluable resource for a variety of genomic fields. Although our analysis is confined to static expression data, GRANITE has the capability of evaluating time-course data and generating interactive networks that may shed light on acute versus chronic treatment, as well as evaluating dose response and providing insight into mechanisms that underlie therapeutic versus sub-therapeutic doses or toxic doses. As a proof-of-concept study, we investigated lithium (Li) response in bipolar disorder (BD). BD is a severe mood disorder marked by cycles of mania and depression. Li is one of the most commonly prescribed and decidedly effective treatments for many patients (responders), although its mode of action is not yet fully understood, nor is it effective in every patient (non-responders). In an in vitro study, we compared vehicle versus chronic Li treatment in patient-derived lymphoblastoid cells (LCLs) (derived from either responders or non-responders) using both microRNA (miRNA) and messenger RNA gene expression profiling. We present both Li responder and non-responder network visualizations created by our GRANITE analysis in BD. We identified by network visualization that the Let-7 family is consistently downregulated by Li in both groups where this miRNA family has been implicated in neurodegeneration, cell survival and synaptic development. We discuss the potential of this analysis for investigating treatment response and even providing clinicians with a tool for predicting treatment response in their patients, as well as for providing the industry with a tool for identifying network nodes as targets for novel drug discovery