A multi-agent model to study epidemic spreading and vaccination strategies in an urban-like environment

Worldwide urbanization calls for a deeper understanding of epidemic spreading within urban environments. Here, we tackle this problem through an agent-based model, in which agents move in a two-dimensional physical space and interact according to proximity criteria. The planar space comprises several locations, which represent bounded regions of the urban space. Based on empirical evidence, we consider locations of different density and place them in a core-periphery structure, with higher density in the central areas and lower density in the peripheral ones. Each agent is assigned to a base location, which represents where their home is. Through analytical tools and numerical techniques, we study the formation mechanism of the network of contacts, which is characterized by the emergence of heterogeneous interaction patterns. We put forward an extensive simulation campaign to analyze the onset and evolution of contagious diseases spreading in the urban environment. Interestingly, we find that, in the presence of a core-periphery structure, the diffusion of the disease is not affected by the time agents spend inside their base location before leaving it, but it is influenced by their motion outside their base location: a strong tendency to return to the base location favors the spreading of the disease. A simplified one-dimensional version of the model is examined to gain analytical insight into the spreading process and support our numerical findings. Finally, we investigate the effectiveness of vaccination campaigns, supporting the intuition that vaccination in central and dense areas should be prioritized

A multi-agent model to study epidemic spreading and vaccination strategies in an urban-like environment

Worldwide urbanization calls for a deeper understanding of epidemic spreading within urban environments. Here, we tackle this problem through an agent-based model, in which agents move in a two-dimensional physical space and interact according to proximity criteria. The planar space comprises several locations, which represent bounded regions of the urban space. Based on empirical evidence, we consider locations of different density and place them in a core-periphery structure, with higher density in the central areas and lower density in the peripheral ones. Each agent is assigned to a base location, which represents where their home is. Through analytical tools and numerical techniques, we study the formation mechanism of the network of contacts, which is characterized by the emergence of heterogeneous interaction patterns. We put forward an extensive simulation campaign to analyze the onset and evolution of contagious diseases spreading in the urban environment. Interestingly, we find that, in the presence of a core-periphery structure, the diffusion of the disease is not affected by the time agents spend inside their base location before leaving it, but it is influenced by their motion outside their base location: a strong tendency to return to the base location favors the spreading of the disease. A simplified one-dimensional version of the model is examined to gain analytical insight into the spreading process and support our numerical findings. Finally, we investigate the effectiveness of vaccination campaigns, supporting the intuition that vaccination in central and dense areas should be prioritized

Mapping the NFT revolution: market trends, trade networks and visual features

Non Fungible Tokens (NFTs) are digital assets that represent objects like art, videos, in-game items and music. They are traded online, often with cryptocurrency, and they are generally encoded as smart contracts on a blockchain. Media and public attention towards NFTs has exploded in 2021, when the NFT art market has experienced record sales while celebrated new star artists. However, little is known about the overall structure and evolution of the NFT market. Here, we analyse data concerning 6.1 million trades of 4.7 million NFTs generating a total trading volume of 935 millions US dollars. Our data are obtained primarily from the Ethereum and WAX blockchains and cover the period between June 23, 2017 and April 27, 2021. First, we characterize the statistical properties of the market. Second, we build the network of interactions and show that traders have bursts of activity followed by inactive periods, and typically specialize on NFTs associated to similar objects. Third, we cluster objects associated to NFTs according to their visual features and show that NFTs within the same category tend to be visually homogeneous. Finally, we investigate the predictability of NFT sales. We use simple machine learning algorithms and find that prices can be best predicted by the sale history of the NFT collection, but also by some features describing the properties of the associated object (e.g., visual features of digital images). We anticipate that our analysis will be of interest to both researchers and practitioners and will spark further research on the NFT production, adoption and trading in different contexts

Heterogeneous rarity patterns drive price dynamics in NFT collections

We quantify Non Fungible Token (NFT) rarity and investigate how it impacts market behaviour by analysing a dataset of 3.7M transactions collected between January 2018 and June 2022, involving 1.4M NFTs distributed across 410 collections. First, we consider the rarity of an NFT based on the set of human-readable attributes it possesses and show that most collections present heterogeneous rarity patterns, with few rare NFTs and a large number of more common ones. Then, we analyze market performance and show that, on average, rarer NFTs: (i) sell for higher prices, (ii) are traded less frequently, (iii) guarantee higher returns on investment, and (iv) are less risky, i.e., less prone to yield negative returns. We anticipate that these findings will be of interest to researchers as well as NFT creators, collectors, and traders

Emergence and structure of decentralised trade networks around dark web marketplaces

Dark web marketplaces (DWMs) are online platforms that facilitate illicit trade among millions of users generating billions of dollars in annual revenue. Recently, two interview-based studies have suggested that DWMs may also promote the emergence of direct user-to-user (U2U) trading relationships. Here, we carefully investigate and quantify the scale of U2U trading around DWMs by analysing 31 million Bitcoin transactions among users of 40 DWMs between June 2011 and Jan 2021. We find that half of the DWM users trade through U2U pairs generating a total trading volume greater than DWMs themselves. We then show that hundreds of thousands of DWM users form stable trading pairs that are persistent over time. Users in such stable pairs turn out to be the ones with the largest trading volume on DWMs. Then, we show that new U2U pairs often form while both users are active on the same DWM, suggesting the marketplace may serve as a catalyst for new direct trading relationships. Finally, we reveal that stable U2U pairs tend to survive DWM closures and that they were not affected by COVID-19, indicating that their trading activity is resilient to external shocks. Our work unveils sophisticated patterns of trade emerging in the dark web and highlights the importance of investigating user behaviour beyond the immediate buyer-seller network on a single marketplace

Vaccines and more: The response of Dark Web marketplaces to the ongoing COVID-19 pandemic

Early analyses revealed that dark web marketplaces (DWMs) started offering COVID-19 related products (e.g., masks and COVID-19 tests) as soon as the COVID-19 pandemic started, when these goods were in shortage in the traditional economy. Here, we broaden the scope and depth of previous investigations by considering how DWMs responded to an ongoing pandemic after the initial shock. Our dataset contains listings from 194 DWMs collected until July 2021. We start by focusing on vaccines. We find 248 listings offering approved vaccines, like Pfizer/BioNTech and AstraZeneca, as well as vendors offering fabricated proofs of vaccination and COVID-19 passports. Then, we consider COVID-19 related products. We show that, as the regular economy has become able to satisfy the demand of these goods, DWMs have decreased their offer. Next, we analyse the profile of vendors of COVID-19 related products and vaccines. We find that most of them are specialized in a single type of listings and are willing to ship worldwide. Finally, we consider a broader set of listings mentioning COVID-19, in order to assess the general impact of the pandemic on the broader activity of DWMs. Among 10,330 such listings, we show that recreational drugs are the most affected among traditional DWMs product, with COVID-19 mentions steadily increasing since March 2020. We anticipate that our results will be of interest to researchers, practitioners, and law enforcement agencies focused on the study and safeguard of public health

Dark Web Marketplaces and COVID-19: before the vaccine

The COVID-19 pandemic has reshaped the demand for goods and services worldwide. The combination of a public health emergency, economic distress, and misinformation-driven panic have pushed customers and vendors towards the shadow economy. In particular, dark web marketplaces (DWMs), commercial websites accessible via free software, have gained significant popularity. Here, we analyse 851,199 listings extracted from 30 DWMs between January 1, 2020 and November 16, 2020. We identify 788 listings directly related to COVID-19 products and monitor the temporal evolution of product categories including Personal Protective Equipment (PPE), medicines (e.g., hydroxyclorochine), and medical frauds. Finally, we compare trends in their temporal evolution with variations in public attention, as measured by Twitter posts and Wikipedia page visits. We reveal how the online shadow economy has evolved during the COVID-19 pandemic and highlight the importance of a continuous monitoring of DWMs, especially now that real vaccines are available and in short supply. We anticipate our analysis will be of interest both to researchers and public agencies focused on the protection of public health

The effects of local and global link creation mechanisms on contagion processes unfolding on time-varying networks

Social closeness and popularity are key ingredients that shape the emergence and evolution of social connections over time. Social closeness captures local reinforcement mechanisms which are behind the formation of strong ties and communities. Popularity, on the other hand, describes global link formation dynamics which drive, among other things, hubs, weak ties and bridges between groups. In this chapter, we characterize how these mechanisms affect spreading processes taking place on time-varying networks. We study contagion phenomena unfolding on a family of artificial temporal networks. In particular, we revise four different variations of activity-driven networks that capture i) heterogeneity of activation patterns ii) popularity iii) the emergence of strong and weak ties iv) community structure. By means of analytical and numerical analyses we uncover a rich and process dependent phenomenology where the interplay between spreading phenomena and link formation mechanisms might either speed up or slow down the spreadin

Synthesis, characterization and biological evaluation of dipicolylamine sulfonamide derivatized platinum complexes as potential anticancer agents

Three new Pt complexes, [PtCl(N(SO(2-nap))dpa)], [PtCl(N(SO(1-nap))dpa)] and [PtCl(N(SOpip)dpa)], containing a rare 8-membered ring were synthesized in good yield and high purity by utilizing the ligands N(SO(2-nap))dpa, N(SO(1-nap))dpa and N(SOpip)dpa, which contain a dipicolylamine moiety. Structural studies of all three complexes confirmed that the ligands are bound in a bidentate mode Pt-N bonds forming a rare 8-membered ring. The intense fluorescence displayed by the ligands is quenched upon coordination to Pt. According to time dependent density functional theory (TDDFT) calculations, the key excitations of N(SO(2-nap))dpa and [PtCl(N(SO(1-nap))dpa)] involve the 2-nap-ligand-centered π → π* excitations. While all six compounds have shown antiproliferative activity against human breast cancer cells (MCF-7), the N(SOpip)dpa and N(SO(2-nap))dpa ligands and [PtCl((NSOpip)dpa)] complex have shown significantly high cytotoxicity, directing them to be further investigated as potential anti-cancer drug leads